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Published ahead of print on July 14, 2005, doi:10.1164/rccm.200501-098WS
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American Journal of Respiratory and Critical Care Medicine Vol 172. pp. 944-955, (2005)
© 2005 American Thoracic Society
doi: 10.1164/rccm.200501-098WS

NHLBI Workshop

Lung Transplantation

Opportunities for Research and Clinical Advancement

David S. Wilkes*, Thomas M. Egan* and Herbert Y. Reynolds

Indiana University School of Medicine, Indianapolis, Indiana; University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; and National Heart, Lung, and Blood Institute, Bethesda, Maryland

Correspondence and requests for reprints should be addressed to Herbert Y. Reynolds, M.D., DLD/NHLBI, Two Rockledge Center, 6701 Rockledge Drive, Bethesda, MD 20892-7592. E-mail: reynoldh{at}mail.nih.gov

Lung transplantation is the only definitive therapy for many forms of end-stage lung diseases. However, the success of lung transplantation is limited by many factors: (1) Too few lungs available for transplantation due to limited donors or injury to the donor lung; (2) current methods of preservation of excised lungs do not allow extended periods of time between procurement and implantation; (3) acute graft failure is more common with lungs than other solid organs, thus contributing to poorer short-term survival after lung transplant compared with that for recipients of other organs; (4) lung transplant recipients are particularly vulnerable to pulmonary infections; and (5) chronic allograft dysfunction, manifest by bronchiolitis obliterans syndrome, is frequent and limits long-term survival. Scientific advances may provide significant improvements in the outcome of lung transplantation. The National Heart, Lung, and Blood Institute convened a working group of investigators on June 14–15, 2004, in Bethesda, Maryland, to identify opportunities for scientific advancement in lung transplantation, including basic and clinical research. This workshop provides a framework to identify critical issues related to clinical lung transplantation, and to delineate important areas for productive scientific investigation.

Key Words: allograft dysfunction • infection • ischemia-reperfusion injury • lung transplantation • obliterative bronchiolitis • rejection




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