help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Published ahead of print on May 13, 2005, doi:10.1164/rccm.200501-017PP
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200501-017PPv1
172/4/417    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kinnula, V. L.
Right arrow Articles by Oury, T. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kinnula, V. L.
Right arrow Articles by Oury, T. D.
American Journal of Respiratory and Critical Care Medicine Vol 172. pp. 417-422, (2005)
© 2005 American Thoracic Society
doi: 10.1164/rccm.200501-017PP

Pulmonary Perspective

Oxidative Stress in Pulmonary Fibrosis

A Possible Role for Redox Modulatory Therapy

Vuokko L. Kinnula, Cheryl L. Fattman, Roderick J. Tan and Tim D. Oury

Division of Pulmonary Medicine, Department of Medicine, University of Helsinki, Helsinki, Finland; and Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania

Correspondence and requests for reprints should be addressed to Vuokko Kinnula, M.D., Ph.D., Department of Medicine, Division of Pulmonary Medicine, University of Helsinki, P.O. Box 22 (Haartmaninkatu 4), FI-00014 Helsinki, Finland. E-mail: vuokko.kinnula{at}helsinki.fi

ABSTRACT

Idiopathic ulmonary fibrosis (histopathology of usual interstitial pneumonia) is a progressive lung disease of unknown etiology. No treatment has been shown to improve the prognosis of the patients with this disease. Recent evidence, including the observations that the patients with idiopathic pulmonary fibrosis have higher levels of oxidant stress than control patients, and a recent multicenter European study examining the effect of the antioxidant N-acetylcysteine on the progression of idiopathic pulmonary fibrosis suggest that the cellular redox state may play a significant role in the progression of this disease. These complex mechanisms include activation of growth factors as well as regulation of matrix metalloproteinases and protease inhibitors. Potential future approaches for the therapy of interstitial pulmonary fibrosis may involve synthetic agents able to modulate cellular redox state. Investigation into therapeutic approaches to inhibit oxidant-mediated reactions in the initiation and progression of pulmonary fibrosis may provide hope for the future treatment of this disease.

Key Words: antioxidant • idiopathic pulmonary fibrosis • oxidant • radical




This article has been cited by other articles:


Home page
 J. Histochem. Cytochem.Home page
K. Vuorinen, S. Ohlmeier, O. Lepparanta, K. Salmenkivi, M. Myllarniemi, and V. L. Kinnula
Peroxiredoxin II Expression and Its Association With Oxidative Stress and Cell Proliferation in Human Idiopathic Pulmonary Fibrosis
J. Histochem. Cytochem., October 1, 2008; 56(10): 951 - 959.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. Behr and J. H. Ryu
Pulmonary hypertension in interstitial lung disease
Eur. Respir. J., June 1, 2008; 31(6): 1357 - 1367.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Sato, T. Shimosato, W. G. Alvord, and D. M. Klinman
Suppressive Oligodeoxynucleotides Inhibit Silica-Induced Pulmonary Inflammation
J. Immunol., June 1, 2008; 180(11): 7648 - 7654.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
Q. Ye, Y. Dalavanga, N. Poulakis, S. U. Sixt, J. Guzman, and U. Costabel
Decreased expression of haem oxygenase-1 by alveolar macrophages in idiopathic pulmonary fibrosis
Eur. Respir. J., May 1, 2008; 31(5): 1030 - 1036.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Gao, J. R. Koenitzer, J. M. Tobolewski, D. Jiang, J. Liang, P. W. Noble, and T. D. Oury
Extracellular Superoxide Dismutase Inhibits Inflammation by Preventing Oxidative Fragmentation of Hyaluronan
J. Biol. Chem., March 7, 2008; 283(10): 6058 - 6066.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. Clement and E. Eber
Interstitial lung diseases in infants and children
Eur. Respir. J., March 1, 2008; 31(3): 658 - 666.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. M. Antoniou, D. M. Hansell, M. B. Rubens, K. Marten, S. R. Desai, N. M. Siafakas, A. G. Nicholson, R. M. du Bois, and A. U. Wells
Idiopathic Pulmonary Fibrosis: Outcome in Relation to Smoking Status
Am. J. Respir. Crit. Care Med., January 15, 2008; 177(2): 190 - 194.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T. M. Maher, A. U. Wells, and G. J. Laurent
Idiopathic pulmonary fibrosis: multiple causes and multiple mechanisms?
Eur. Respir. J., November 1, 2007; 30(5): 835 - 839.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
Y. Kabuyama, K. Oshima, T. Kitamura, M. Homma, J. Yamaki, M. Munakata, and Y. Homma
Involvement of selenoprotein P in the regulation of redox balance and myofibroblast viability in idiopathic pulmonary fibrosis.
Genes Cells, November 1, 2007; 12(11): 1235 - 1244.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
I. Noth and F. J. Martinez
Recent Advances in Idiopathic Pulmonary Fibrosis
Chest, August 1, 2007; 132(2): 637 - 650.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. D. Nathan, P. W. Noble, and R. M. Tuder
Idiopathic Pulmonary Fibrosis and Pulmonary Hypertension: Connecting the Dots
Am. J. Respir. Crit. Care Med., May 1, 2007; 175(9): 875 - 880.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
N. L. Reynaert, E. F. M. Wouters, and Y. M. W. Janssen-Heininger
Modulation of Glutaredoxin-1 Expression in a Mouse Model of Allergic Airway Disease
Am. J. Respir. Cell Mol. Biol., February 1, 2007; 36(2): 147 - 151.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Sato, M. Takeno, K. Honma, H. Yamauchi, Y. Saito, T. Sasaki, H. Morikubo, Y. Nagashima, S. Takagi, K. Yamanaka, et al.
Heme Oxygenase-1, a Potential Biomarker of Chronic Silicosis, Attenuates Silica-induced Lung Injury
Am. J. Respir. Crit. Care Med., October 15, 2006; 174(8): 906 - 914.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. J. Tan, C. L. Fattman, L. M. Niehouse, J. M. Tobolewski, L. E. Hanford, Q. Li, F. A. Monzon, W. C. Parks, and T. D. Oury
Matrix Metalloproteinases Promote Inflammation and Fibrosis in Asbestos-Induced Lung Injury in Mice
Am. J. Respir. Cell Mol. Biol., September 1, 2006; 35(3): 289 - 297.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Carnevali, F. Luppi, D. D'Arca, A. Caporali, M. P. Ruggieri, M. V. Vettori, A. Caglieri, S. Astancolle, F. Panico, P. Davalli, et al.
Clusterin Decreases Oxidative Stress in Lung Fibroblasts Exposed to Cigarette Smoke
Am. J. Respir. Crit. Care Med., August 15, 2006; 174(4): 393 - 399.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. J. Martinez and M. P. Keane
Update in diffuse parenchymal lung diseases 2005.
Am. J. Respir. Crit. Care Med., May 15, 2006; 173(10): 1066 - 1071.
[Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. J. Tan, J. S. Lee, M. L. Manni, C. L. Fattman, J. M. Tobolewski, M. Zheng, J. K. Kolls, T. R. Martin, and T. D. Oury
Inflammatory Cells as a Source of Airspace Extracellular Superoxide Dismutase after Pulmonary Injury
Am. J. Respir. Cell Mol. Biol., February 1, 2006; 34(2): 226 - 232.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
N. Walter, H. R. Collard, and T. E. King Jr.
Current perspectives on the treatment of idiopathic pulmonary fibrosis.
Proceedings of the ATS, January 1, 2006; 3(4): 330 - 338.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2005 American Thoracic Society 		  ATS State of the Art 2009