help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

Published ahead of print on April 14, 2005, doi:10.1164/rccm.200401-006OC
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Online Supplement
Right arrow All Versions of this Article:
200401-006OCv1
172/2/189    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chaouat, A.
Right arrow Articles by Weitzenblum, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chaouat, A.
Right arrow Articles by Weitzenblum, E.
American Journal of Respiratory and Critical Care Medicine Vol 172. pp. 189-194, (2005)
© 2005 American Thoracic Society
doi: 10.1164/rccm.200401-006OC


Original Article

Severe Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease

Ari Chaouat, Anne-Sophie Bugnet, Nabila Kadaoui, Roland Schott, Irina Enache, Alain Ducoloné, May Ehrhart, Romain Kessler and Emmanuel Weitzenblum

Service de Pneumologie, Hôpital de Hautepierre, Strasbourg, France

Correspondence and requests for reprints should be addressed to Ari Chaouat, M.D., Service de Pneumologie, Hôpital de Hautepierre, Avenue Molière, 67098 Strasbourg Cedex, France. E-mail: ari.chaouat{at}chru-strasbourg.fr

Rationale: Severe pulmonary hypertension occurs occasionally in patients with chronic obstructive pulmonary disease (COPD), but no detailed description of these patients is available. Objectives: To identify and characterize patients with COPD and severe pulmonary hypertension. Methods: Retrospective study of 27 patients with COPD with severe pulmonary hypertension (pulmonary artery mean pressure [Ppa], >= 40 mm Hg) among 998 patients who underwent right heart catheterization between 1990 and 2002 as part of a workup for chronic respiratory failure during a period of disease stability. Results: Of the 27 patients, 16 had another disease capable of causing pulmonary hypertension. The remaining 11 (11 of 998, 1.1%) patients had COPD as the only cause of pulmonary hypertension, with a median Ppa of 48 mm Hg (interquartile range, 46–50). They had an unusual pattern of cardiopulmonary abnormalities with mild to moderate airway obstruction, severe hypoxemia, hypocapnia, and a very low diffusing capacity for carbon monoxide (p < 0.01 compared with a control group of patients with COPD). Exertional dyspnea was more severe (p < 0.01) and survival was shorter (p = 0.0026) than in the control subjects. Conclusions: Severe pulmonary hypertension is uncommon in patients with COPD. When it occurs, another cause must be sought. COPD with severe pulmonary hypertension and no other possible cause shares features with pulmonary vascular diseases, such as idiopathic pulmonary hypertension.

Key Words: chronic obstructive pulmonary disease • pulmonary artery pressure • pulmonary hypertension • respiratory function tests




This article has been cited by other articles:


Home page
Eur Heart JHome page
Authors/Task Force Members, N. Galie, M. M. Hoeper, M. Humbert, A. Torbicki, J.-L. Vachiery, J. A. Barbera, M. Beghetti, P. Corris, S. Gaine, et al.
Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT)
Eur. Heart J., October 2, 2009; 30(20): 2493 - 2537.
[Full Text] [PDF]


Home page
ChestHome page
M. K. Steiner
World Health Organization Class III COPD-Associated Pulmonary Hypertension: Are We There Yet in Understanding the Pathobiology of the Disease?
Chest, September 1, 2009; 136(3): 658 - 659.
[Full Text] [PDF]


Home page
ChestHome page
A. Chaouat, L. Savale, C. Chouaid, L. Tu, B. Sztrymf, M. Canuet, B. Maitre, B. Housset, C. Brandt, P. Le Corvoisier, et al.
Role for Interleukin-6 in COPD-Related Pulmonary Hypertension
Chest, September 1, 2009; 136(3): 678 - 687.
[Abstract] [Full Text] [PDF]


Home page
Chronic Respiratory DiseaseHome page
E Weitzenblum and A Chaouat
Cor pulmonale
Chronic Respiratory Disease, August 1, 2009; 6(3): 177 - 185.
[Abstract] [PDF]


Home page
J Am Coll CardiolHome page
G. Simonneau, I. M. Robbins, M. Beghetti, R. N. Channick, M. Delcroix, C. P. Denton, C. G. Elliott, S. P. Gaine, M. T. Gladwin, Z.-C. Jing, et al.
Updated clinical classification of pulmonary hypertension.
J. Am. Coll. Cardiol., June 30, 2009; 54(1 Suppl): S43 - S54.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
M. M. Hoeper, J. A. Barbera, R. N. Channick, P. M. Hassoun, I. M. Lang, A. Manes, F. J. Martinez, R. Naeije, H. Olschewski, J. Pepke-Zaba, et al.
Diagnosis, assessment, and treatment of non-pulmonary arterial hypertension pulmonary hypertension.
J. Am. Coll. Cardiol., June 30, 2009; 54(1 Suppl): S85 - S96.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
V. V. McLaughlin, S. L. Archer, D. B. Badesch, R. J. Barst, H. W. Farber, J. R. Lindner, M. A. Mathier, M. D. McGoon, M. H. Park, R. S. Rosenson, et al.
ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension: A Report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association Developed in Collaboration With the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association
J. Am. Coll. Cardiol., April 28, 2009; 53(17): 1573 - 1619.
[Full Text] [PDF]


Home page
CirculationHome page
Writing Committee Members, V. V. McLaughlin, S. L. Archer, D. B. Badesch, R. J. Barst, H. W. Farber, J. R. Lindner, M. A. Mathier, M. D. McGoon, M. H. Park, et al.
ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension: A Report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association: Developed in Collaboration With the American College of Chest Physicians, American Thoracic Society, Inc., and the Pulmonary Hypertension Association
Circulation, April 28, 2009; 119(16): 2250 - 2294.
[Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
M. Humbert
Update in Pulmonary Hypertension 2008
Am. J. Respir. Crit. Care Med., April 15, 2009; 179(8): 650 - 656.
[Full Text] [PDF]


Home page
Am. J. Pathol.Home page
E. C. Dempsey, M. J. Wick, V. Karoor, E. J. Barr, D. W. Tallman, C. A. Wehling, S. J. Walchak, S. Laudi, M. Le, M. Oka, et al.
Neprilysin Null Mice Develop Exaggerated Pulmonary Vascular Remodeling in Response to Chronic Hypoxia
Am. J. Pathol., March 1, 2009; 174(3): 782 - 796.
[Abstract] [Full Text] [PDF]


Home page
Eur Respir JHome page
C. Jardim and R. Souza
Pulmonary hypertension therapy and COPD: still many questions to be answered
Eur. Respir. J., February 1, 2009; 33(2): 449 - 449.
[Full Text] [PDF]


Home page
Eur Respir JHome page
V. Cottin, C. Khouatra, R. Lazor, P. Canu, and J-F. Cordier
To the Editors
Eur. Respir. J., February 1, 2009; 33(2): 450 - 452.
[Full Text] [PDF]


Home page
ChestHome page
M. J. Hegewald and C. G. Elliott
Sustained Improvement With Iloprost in a COPD Patient With Severe Pulmonary Hypertension
Chest, February 1, 2009; 135(2): 536 - 537.
[Abstract] [Full Text] [PDF]


Home page
J. Physiol.Home page
T. G. Smith, G. M. Balanos, Q. P. P. Croft, N. P. Talbot, K. L. Dorrington, P. J. Ratcliffe, and P. A. Robbins
The increase in pulmonary arterial pressure caused by hypoxia depends on iron status
J. Physiol., December 15, 2008; 586(24): 5999 - 6005.
[Abstract] [Full Text] [PDF]


Home page
Eur Respir JHome page
A. Chaouat, R. Naeije, and E. Weitzenblum
Pulmonary hypertension in COPD
Eur. Respir. J., November 1, 2008; 32(5): 1371 - 1385.
[Abstract] [Full Text] [PDF]


Home page
Eur Respir JHome page
M. M. Hoeper
Treating pulmonary hypertension in COPD: where do we start?
Eur. Respir. J., September 1, 2008; 32(3): 541 - 542.
[Full Text] [PDF]


Home page
Proc Am Thorac SocHome page
J. A. Falk, S. Kadiev, G. J. Criner, S. M. Scharf, O. A. Minai, and P. Diaz
Cardiac Disease in Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, May 1, 2008; 5(4): 543 - 548.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
M. Humbert
Update in Pulmonary Arterial Hypertension 2007
Am. J. Respir. Crit. Care Med., March 15, 2008; 177(6): 574 - 579.
[Full Text] [PDF]


Home page
CirculationHome page
M. K. Han, V. V. McLaughlin, G. J. Criner, and F. J. Martinez
Pulmonary Diseases and the Heart
Circulation, December 18, 2007; 116(25): 2992 - 3005.
[Abstract] [Full Text] [PDF]


Home page
Eur Respir JHome page
A. F. Shorr, J. L. Wainright, C. S. Cors, C. J. Lettieri, and S. D. Nathan
Pulmonary hypertension in patients with pulmonary fibrosis awaiting lung transplant
Eur. Respir. J., October 1, 2007; 30(4): 715 - 721.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
H. A. Ghofrani, R. Voswinckel, F. Reichenberger, N. Weissmann, R. T. Schermuly, W. Seeger, and F. Grimminger
Hypoxia- and non-hypoxia-related pulmonary hypertension - Established and new therapies
Cardiovasc Res, October 1, 2006; 72(1): 30 - 40.
[Abstract] [Full Text] [PDF]


Home page
Eur Respir JHome page
B. Beghe, E. Bazzan, S. Baraldo, F. Calabrese, F. Rea, M. Loy, P. Maestrelli, R. Zuin, L. M. Fabbri, and M. Saetta
Transforming growth factor-{beta} type II receptor in pulmonary arteries of patients with very severe COPD
Eur. Respir. J., September 1, 2006; 28(3): 556 - 562.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
L. M. Fabbri, F. Luppi, B. Beghe, and K. F. Rabe
Update in chronic obstructive pulmonary disease 2005.
Am. J. Respir. Crit. Care Med., May 15, 2006; 173(10): 1056 - 1065.
[Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
H. H. Leuchte, R. A. Baumgartner, M. E. Nounou, M. Vogeser, C. Neurohr, M. Trautnitz, and J. Behr
Brain Natriuretic Peptide Is a Prognostic Parameter in Chronic Lung Disease
Am. J. Respir. Crit. Care Med., April 1, 2006; 173(7): 744 - 750.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
M. M. Hoeper and L. J. Rubin
Update in pulmonary hypertension 2005.
Am. J. Respir. Crit. Care Med., March 1, 2006; 173(5): 499 - 505.
[Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2005 American Thoracic Society
  Work-Life