Published ahead of print on September 22, 2005, doi:10.1164/rccm.200502-230OC
© 2005 American Thoracic Society doi: 10.1164/rccm.200502-230OC
Effect of Ductus Ligation on Cardiopulmonary Function in Premature BaboonsSouthwest Foundation for Biomedical Research; Departments of Pediatrics, Pathology, Obstetrics-Gynecology, and Cardiothoracic Surgery, University of Texas Health Science Center; Wilford Hall Medical Center, San Antonio; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas; and Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, San Francisco, California Correspondence and requests for reprints should be addressed to Donald McCurnin, M.D., MSC 7812, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900. E-mail: mccurnin{at}uthscsa.edu Rationale: The role of the patent ductus arteriosus in the development of chronic lung disease in surfactant-treated premature newborns remains unclear. Objective: To examine the effects of ductus ligation on cardiopulmonary function and lung histopathology in premature primates. Methods: Baboons were delivered at 125 d, (term = 185 d) treated with surfactant, and ventilated for 14 d. Serial echocardiograms and pulmonary function tests were performed. Animals were randomized to ligation (n = 12) or no ligation (controls, n = 13) on Day 6 of life. Necropsy was performed on Day 14. Results: Compared with nonligated control animals, ligated animals had lower pulmonary-to-systemic flow ratios, higher systemic blood pressures, and improved indices of right and left ventricular performance. The ligated animals tended to have better compliance and ventilation indices for the last 3 d of the study. There were no differences between the groups in proinflammatory tracheal cytokines (interleukin [IL] 6 and IL-8), static lung compliance, or lung histology. Conclusion: Although a persistent patent ductus arteriosus results in diminished cardiac function and increased ventilatory requirements at the end of the second week of life, ligation on Day 6 had no measurable effect on the histologic evolution of chronic lung injury in this 14-d baboon model.
Key Words: bronchopulmonary dysplasia • chronic lung disease • patent ductus arteriosus • premature newborn This article has been cited by other articles:
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