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Published ahead of print on November 19, 2004, doi:10.1164/rccm.200407-928OC
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American Journal of Respiratory and Critical Care Medicine Vol 171. pp. 282-286, (2005)
© 2005 American Thoracic Society
doi: 10.1164/rccm.200407-928OC

Original Article

Morning Levels of C-Reactive Protein in Children with Obstructive Sleep-disordered Breathing

Athanasios G. Kaditis, Emmanouel I. Alexopoulos, Efthimia Kalampouka, Eleni Kostadima, Anastasios Germenis, Elias Zintzaras and Konstantinos Gourgoulianis

Departments of Pediatrics, Pediatric Pulmonology Unit, Immunology, and Biomathematics, and Sleep Disorders Laboratory, University of Thessaly School of Medicine and Larissa University Hospital, Larissa, Greece

Correspondence and requests for reprints should be addressed to Athanasios Kaditis, M.D., Larissa University Hospital, Department of Pediatrics, P.O. Box 1425, Larissa 41110, Greece. E-mail: kaditia{at}hotmail.com

Obstructive sleep-disordered breathing is associated with cardiovascular disease in adults, and elevated C-reactive protein (CRP) has been proposed as a link between the two disorders. We hypothesized that children with sleep-disordered breathing have higher CRP values than do control subjects. CRP was measured in 39 children (mean age ± SD: 6.9 ± 3.2 years) without snoring (controls) and in 102 children (6.2 ± 2.2 years) with habitual snoring who underwent polysomnography. No significant differences were found in mean CRP values between control subjects (0.12 ± 0.16 mg/dl; n = 39) and snorers with an apnea-hypopnea index of less than 1 episode/hour (0.15 ± 0.26; n = 18), snorers with an index of 1 or more and less than 5 (0.15 ± 0.26; n = 54), and snorers with an index of 5 or more (0.22 ± 0.43; n = 30; p > 0.05). There was no correlation between CRP or log-transformed CRP values and apnea–hypopnea index, respiratory movement/arousal index, SaO2 nadir, oxygen desaturation (>= 4%) of hemoglobin index, or percentage of sleep time with saturation less than 95% (p > 0.05). Thus, findings of higher CRP values in adults with sleep-disordered breathing and correlations of these values with polysomnography indices were not confirmed in children.

Key Words: atherosclerosis • obstructive sleep apnea • snoring




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