help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Published ahead of print on February 11, 2005, doi:10.1164/rccm.200501-046OC
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200501-046OCv1
171/10/1178    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bard, M. P. L.
Right arrow Articles by Aerts, J. G. J. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bard, M. P. L.
Right arrow Articles by Aerts, J. G. J. V.
American Journal of Respiratory and Critical Care Medicine Vol 171. pp. 1178-1184, (2005)
© 2005 American Thoracic Society
doi: 10.1164/rccm.200501-046OC

Original Article

Measurement of Hypoxia-related Parameters in Bronchial Mucosa by Use of Optical Spectroscopy

Martin P. L. Bard, Arjen Amelink, Vincent Noordhoek Hegt, Wilfried J. Graveland, Henricus J. C. M. Sterenborg, Henk C. Hoogsteden and Joachim G. J. V. Aerts

Department of Respiratory Diseases, Center for Optical Diagnostics and Therapy; Departments of Radiation Oncology and Statistics, Erasmus Medical Centre Rotterdam; and Departments of Pathology and Respiratory Diseases, Sint Franciscus Hospital, Rotterdam, the Netherlands

Correspondence and requests for reprints should be addressed to Joachim Aerts, M.D., Ph.D., Department of Respiratory Diseases, Sint Franciscus Hospital, Kleiweg 500, Rotterdam 3045 PM, the Netherlands. E-mail: j.aerts{at}sfg.nl

Rationale: Tumor hypoxia has both prognostic and therapeutic consequences for solid tumors. We developed a novel noninvasive technique, differential path-length spectroscopy (DPS), which allows the measurement of hypoxia-related parameters in the superficial microvasculature of tissue. Objectives: The aim of this study was to measure the microvascular oxygenation of histologically normal endobronchial mucosa and of neoplastic lesions during bronchoscopy using DPS. Methods: Sixty-four patients with known or suspected malignancies of the lung were studied. One hundred and five endobronchial lesions (38 histologically normal, 37 metaplastic/mild dysplastic lesions, and 30 invasive carcinomas) were detected by white and/or autofluorescence bronchoscopy and measured using DPS. Results: We observed that bronchial tumors are characterized by a lower blood oxygen saturation and a higher blood content than normal mucosa. No differences were observed between normal and metaplastic/mild dysplastic mucosa. Conclusion: DPS is a new optical technique allowing the noninvasive study of endobronchial tumor hypoxia.

Key Words: cancer • hypoxia • lung • optical spectroscopy • premalignant




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
L. Thiberville, S. Moreno-Swirc, T. Vercauteren, E. Peltier, C. Cave, and G. Bourg Heckly
In Vivo Imaging of the Bronchial Wall Microstructure Using Fibered Confocal Fluorescence Microscopy
Am. J. Respir. Crit. Care Med., January 1, 2007; 175(1): 22 - 31.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. R. Jett and Y. E. Miller
Update in lung cancer 2005.
Am. J. Respir. Crit. Care Med., April 1, 2006; 173(7): 695 - 697.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2005 American Thoracic Society 		  Red Transition