help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Published ahead of print on October 11, 2004, doi:10.1164/rccm.200403-298OC
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200403-298OCv1
171/1/68    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Baraldi, E.
Right arrow Articles by Filippone, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Baraldi, E.
Right arrow Articles by Filippone, M.
American Journal of Respiratory and Critical Care Medicine Vol 171. pp. 68-72, (2005)
© 2005 American Thoracic Society
doi: 10.1164/rccm.200403-298OC

Original Article

Low Exhaled Nitric Oxide in School-Age Children with Bronchopulmonary Dysplasia and Airflow Limitation

Eugenio Baraldi, Gea Bonetto, Franco Zacchello and Marco Filippone

Department of Pediatrics, School of Medicine, University of Padova, Padova, Italy

Correspondence and requests for reprints should be addressed to Eugenio Baraldi, Department of Pediatrics, Via Giustiniani 3, 35128 Padova, Italy. E-mail: baraldi{at}pediatria.unipd.it

Bronchopulmonary dysplasia (BPD), the chronic lung disease of prematurity, may be associated with long-term airflow limitation. Survivors of BPD may develop asthma-like symptoms in childhood, with a variable response to ß2-agonists. However, the pathologic pathways underlying these respiratory manifestations are still unknown. The aim of this study was to measure exhaled nitric oxide (FENO) and lung function in a group of 31 school-age survivors of BPD. They showed variable degrees of airflow obstruction (mean FEV1 77.8 ± 2.3% predicted) unresponsive to ß2-agonists in 72% of the subjects. Their FENO values (geometric mean [95% confidence interval]: 7.7 [± 1.1] ppb) were significantly lower than in a group of healthy matched control subjects born at term (10.7 [± 1.1] ppb, p < 0.05) and a group of preterm children without BPD (9.9 [± 1.1] ppb, p < 0.05). The children with BPD were also compared with a group of 31 patients with asthma with a comparable airflow limitation (FEV1 80.2 ± 2.1% predicted) and showed FENO values four times lower than in those with asthma (24.9 [± 1.2] ppb, p < 0.001). In conclusion, unlike children with asthma, school-age survivors of BPD have airflow limitation associated with low FENO values and lack of reversibility to ß2-agonists, probably as a result of mechanisms related to early life structural changes in the airways.

Key Words: airway remodeling • asthma • bronchopulmonary dysplasia • exhaled nitric oxide • flow limitation




This article has been cited by other articles:


Home page
 PediatricsHome page
L. J. Smith, P. P. van Asperen, K. O. McKay, H. Selvadurai, and D. A. Fitzgerald
Reduced Exercise Capacity in Children Born Very Preterm
Pediatrics, August 1, 2008; 122(2): e287 - e293.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
K. Udomittipong, P. D. Sly, H. J. Patterson, C. L. Gangell, S. M. Stick, and G. L. Hall
Forced oscillations in the clinical setting in young children with neonatal lung disease
Eur. Respir. J., June 1, 2008; 31(6): 1292 - 1299.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bush
Update in Pediatric Lung Disease 2007
Am. J. Respir. Crit. Care Med., April 1, 2008; 177(7): 686 - 695.
[Full Text] [PDF]

Home page
 NEJMHome page
E. Cutz, D. Chiasson, V. Kiren, E. Barbi, A. Ventura, M. Filippone, and E. Baraldi
Chemotherapy plus involved-field radiation in early-stage Hodgkin's disease.
N. Engl. J. Med., February 14, 2008; 358(7): 743 - 743.
[Full Text] [PDF]

Home page
 ChestHome page
T. Kovesi, R. Kulka, and R. Dales
Exhaled Nitric Oxide Concentration Is Affected by Age, Height, and Race in Healthy 9- to 12-Year-Old Children
Chest, January 1, 2008; 133(1): 169 - 175.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
E. Baraldi and M. Filippone
Chronic Lung Disease after Premature Birth
N. Engl. J. Med., November 8, 2007; 357(19): 1946 - 1955.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bush
Update in Pediatric Lung Disease 2006
Am. J. Respir. Crit. Care Med., March 15, 2007; 175(6): 532 - 540.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
H. L. Roiha, C. E. Kuehni, M. Zanolari, M. Zwahlen, D. N. Baldwin, C. Casaulta, M. Nelle, and U. Frey
Alterations of exhaled nitric oxide in pre-term infants with chronic lung disease
Eur. Respir. J., February 1, 2007; 29(2): 251 - 258.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
D. Kohler, P. Haidl, D. Dellweg, L. Bont, J. L.L. Kimpen, M. J.J. Ermers, E. Baraldi, M. Filippone, T. Guilbert, F. D. Martinez, et al.
Inhaled corticosteroids and children.
N. Engl. J. Med., August 10, 2006; 355(6): 624 - 624.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bush
Update in pediatrics 2005.
Am. J. Respir. Crit. Care Med., March 15, 2006; 173(6): 585 - 592.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2005 American Thoracic Society 		  ATS Conference