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Published ahead of print on July 21, 2004, doi:10.1164/rccm.200305-617OC
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American Journal of Respiratory and Critical Care Medicine Vol 170. pp. 870-878, (2004)
© 2004 American Thoracic Society
doi: 10.1164/rccm.200305-617OC

Effects of Testosterone and Resistance Training in Men with Chronic Obstructive Pulmonary Disease

Richard Casaburi, Shalender Bhasin, Louis Cosentino, Janos Porszasz, Attila Somfay, Michael I. Lewis, Mario Fournier and Thomas W. Storer

Division of Endocrinology and Molecular Medicine, Drew University of Medicine and Science; Division of Pulmonary and Critical Care Medicine, Cedars-Sinai Medical Center, Los Angeles; Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center and Exercise Sciences Laboratory, El Camino College, Torrance, California

Correspondence and requests for reprints should be addressed to Richard Casaburi, Ph.D., M.D., Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute, Building RB2, 1124 West Carson Street, Torrance, CA 90502. E-mail: casaburi{at}ucla.edu

Dysfunction of the muscles of ambulation contributes to exercise intolerance in chronic obstructive pulmonary disease (COPD). Men with COPD have high prevalence of low testosterone levels, which may contribute to muscle weakness. We determined effects of testosterone supplementation (100 mg of testosterone enanthate injected weekly) with or without resistance training (45 minutes three times weekly) on body composition and muscle function in 47 men with COPD (mean FEV1 = 40% predicted) and low testosterone levels (mean = 320 ng/dl). Subjects were randomized to 10 weeks of placebo injections + no training, testosterone injections + no training, placebo injections + resistance training, or testosterone injections + resistance training. Testosterone injections yielded a mean increase of 271 ng/dl in the nadir serum testosterone concentration (to the middle of the normal range for young men). The lean body mass (by dual-energy X-ray absorptiometry) increase averaged 2.3 kg with testosterone alone and 3.3 kg with combined testosterone and resistance training (p < 0.001). Increase in one-repetition maximum leg press strength averaged 17.2% with testosterone alone, 17.4% with resistance training alone, and 26.8% with testosterone + resistance training (p < 0.001). Interventions were well tolerated with no abnormalities in safety measures. Further studies are required to determine long-term benefits of adding testosterone supplementation and resistance training to rehabilitative programs for carefully screened men with COPD and low testosterone levels.

Key Words: androgenic steroid • inflammation • muscle mass • strength




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