help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Published ahead of print on July 15, 2004, doi:10.1164/rccm.200312-1674OC
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Online Supplement
Right arrow All Versions of this Article:
200312-1674OCv1
170/7/804    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ogasa, T.
Right arrow Articles by Magalang, U. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ogasa, T.
Right arrow Articles by Magalang, U. J.
American Journal of Respiratory and Critical Care Medicine Vol 170. pp. 804-810, (2004)
© 2004 American Thoracic Society
doi: 10.1164/rccm.200312-1674OC

Original Article

Systemic Administration of Serotonin 2A/2C Agonist Improves Upper Airway Stability in Zucker Rats

Toshiyuki Ogasa, Andrew D. Ray, Charles P. Michlin, Gaspar A. Farkas, Brydon J. B. Grant and Ulysses J. Magalang

Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine; Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, New York; and Department of Medicine, Division of Pulmonary and Critical Care Medicine, The Ohio State University, Columbus, Ohio

Correspondence and requests for reprints should be addressed to Ulysses J. Magalang, M.D., Division of Pulmonary and Critical Care Medicine, 201 Davis Heart and Lung Research Institute, 473 West 12th Avenue, Columbus, OH 43210. E-mail: magalang-1{at}medctr.osu.edu

The effects of [±]-2,5-dimethoxy-4-iodoaminophentamine, a serotonin2A/2C receptor agonist, on pharyngeal airflow mechanics were examined in isoflurane-anesthetized lean and obese Zucker rats. The pharyngeal pressure associated with flow limitation, maximum inspiratory flow, oronasal resistance, genioglossus muscle activity, and arterial blood pressure (BP) were measured before and after the intravenous administration of the agonist. A robust activation of the genioglossus muscle in all lean and obese rats was associated with decreased upper airway (UA) collapsibility (p < 0.05), unchanged maximum flow, and increased oronasal resistance (p < 0.05) in both groups. The changes in UA mechanics and BP after the drug were similar in lean and obese rats. The serotonin agonist had no effect on UA mechanics in a group of paralyzed (pancuronium bromide) rats, despite similar elevations in BP. There was a smaller decrease (p < 0.05) in UA collapsibility that was also associated with increased upstream resistance when the drug was administered after bilateral hypoglossal nerve transection. We conclude that systemic administration of a serotonin2A/2C receptor agonist improves UA collapsibility predominantly, but not exclusively, via stimulation of the hypoglossal nerves and also increases upstream resistance, at least in part, through activation of nonhypoglossal motoneuronal pools innervating the UA muscles.

Key Words: obesity • serotonin • upper airway function




This article has been cited by other articles:


Home page
 Eur Respir JHome page
A. R. Schwartz, S. P. Patil, H. Schneider, and P. L. Smith
Modelling pathogenic mechanisms of upper airway dysfunction in the molecular age
Eur. Respir. J., August 1, 2008; 32(2): 255 - 258.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. D. Ray, U. J. Magalang, C. P. Michlin, T. Ogasa, J. A. Krasney, L. E. Gosselin, and G. A. Farkas
Intermittent hypoxia reduces upper airway stability in lean but not obese Zucker rats
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R372 - R378.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Sood, X. Liu, H. Liu, and R. L. Horner
Genioglossus muscle activity and serotonergic modulation of hypoglossal motor output in obese Zucker rats
J Appl Physiol, June 1, 2007; 102(6): 2240 - 2250.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. R. A. Aoki, H. Liu, G. P. Downey, J. Mitchell, and R. L. Horner
Cyclic Nucleotides Modulate Genioglossus and Hypoglossal Responses to Excitatory Inputs in Rats
Am. J. Respir. Crit. Care Med., March 1, 2006; 173(5): 555 - 565.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Sood, J. L. Morrison, H. Liu, and R. L. Horner
Role of Endogenous Serotonin in Modulating Genioglossus Muscle Activity in Awake and Sleeping Rats
Am. J. Respir. Crit. Care Med., November 15, 2005; 172(10): 1338 - 1347.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. D. Bradley, Y. E. Miller, F. J. Martinez, D. C. Angus, W. MacNee, and E. Abraham
Interstitial Lung Disease, Lung Cancer, Lung Transplantation, Pulmonary Vascular Disorders, and Sleep-disordered Breathing in AJRCCM in 2004
Am. J. Respir. Crit. Care Med., April 1, 2005; 171(7): 675 - 685.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2004 American Thoracic Society