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Published ahead of print on July 8, 2004, doi:10.1164/rccm.200403-346OC
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American Journal of Respiratory and Critical Care Medicine Vol 170. pp. 786-792, (2004)
© 2004 American Thoracic Society
doi: 10.1164/rccm.200403-346OC

Original Article

Impact of Methicillin Resistance on Outcome of Staphylococcus aureus Ventilator-associated Pneumonia

Alain Combes, Charles-Edouard Luyt, Jean-Yves Fagon, Michel Wollf, Jean-Louis Trouillet, Claude Gibert and Jean Chastre for the PNEUMA Trial Group*

Service de Réanimation Médicale, Hôpital Pitié-Salpêtrière, Service de Réanimation Médicale, Hôpital Européen Georges-Pompidou, and Service de Réanimation Médicale, Hôpital Bichat-Claude-Bernard, Assistance Publique–Hôpitaux de Paris, Paris, France

Correspondence and requests for reprints should be addressed to Alain Combes, M.D., Ph.D., Service de Réanimation Médicale, Pr Gibert, Institut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, 47, boulevard de l'Hôpital, 75651 Paris Cedex 13, France. E-mail: alain.combes{at}psl.ap-hop-paris.fr

The impact of methicillin resistance on morbidity and mortality of patients suffering from severe Staphylococcus aureus infections remains highly controversial. We analyzed a retrospective cohort of 97 patients with methicillin-susceptible and 74 patients with methicillin-resistant Staphylococcus aureus ventilator-associated pneumonia (VAP). Initial empiric antibiotic therapy was appropriate for every patient. Patients with methicillin-resistant Staphylococcus aureus VAP were older, had higher disease-severity scores, and had been on mechanical ventilation longer at onset of VAP. Factors associated with 28-day mortality retained by multivariate logistic regression analysis were: age (odds ratio [OR] = 1.05, 95% confidence interval [CI], 1.02–1.08, p = 0.001) and Day 1 organ dysfunctions or infection (ODIN) score (OR = 1.90, 95% CI, 1.31–2.78, p = 0.001), but not methicillin resistance (OR = 1.72, 95% CI, 0.73–4.05, p = 0.22). The percentages of infection relapse or superinfection did not differ significantly between the two patient groups. In conclusion, after controlling for clinical and physiologic heterogeneity between groups, methicillin resistance did not significantly affect 28-day mortality of patients with Staphylococcus aureus VAP receiving appropriate antibiotics.

Key Words: antibiotic-resistant bacteria • multivariate models • outcome assessment • respiration, artificial




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