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Published ahead of print on June 1, 2004, doi:10.1164/rccm.200311-1552OC
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American Journal of Respiratory and Critical Care Medicine Vol 170. pp. 527-533, (2004)
© 2004 American Thoracic Society
doi: 10.1164/rccm.200311-1552OC

Original Article

Development of Lung Function in Early Life

Influence of Birth Weight in Infants of Nonsmokers

Ah-Fong Hoo, Janet Stocks, Sooky Lum, Angie M. Wade, Rosemary A. Castle, Kate L. Costeloe and Carol Dezateux

Portex Respiratory Unit and Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health; and Neonatal Unit, Homerton University Hospital, London, United Kingdom

Correspondence and requests for reprints should be addressed to Ah-Fong Hoo, Portex Respiratory Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. E-mail: a.hoo{at}ich.ucl.ac.uk

This study aimed to compare lung growth and development during the first year of life in healthy term infants of low or appropriate birth weight for gestation. Paired measurements of forced expiratory volume in 0.4 second, FVC, and forced expiratory flow when 75% of FVC has been exhaled were obtained, using the raised volume technique, at about 7 weeks and 9 months of age in 80 infants (32 low and 48 appropriate birth weight for gestation) of white, nonsmoking mothers. Forced flows and volumes increased with growth. Longitudinal trends in results were compared between the two groups, using random effects modeling and adjusted for potential confounding factors. After adjustment for sex, age, and length, forced expiratory volume was significantly reduced by an average (95% confidence interval) of 9% (2 to 16%) in low birth weight compared with appropriate birth weight for gestation infants throughout the first year of life, with a similar trend in forced expiratory flow (8% [–2 to 17%]) and FVC (4% [–3 to 11%]). These findings suggest that lung function is reduced in low birth weight for gestation infants born to nonsmoking white mothers and that this is independent of somatic growth during infancy.

Key Words: fetal growth retardation • follow-up study • forced expiratory volume • infant • respiratory function tests




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