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Published ahead of print on May 6, 2004, doi:10.1164/rccm.200305-648OC
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American Journal of Respiratory and Critical Care Medicine Vol 170. pp. 400-407, (2004)
© 2004 American Thoracic Society

Original Article

Bronchiectasis, Exacerbation Indices, and Inflammation in Chronic Obstructive Pulmonary Disease

Irem S. Patel, Ioannis Vlahos, Tom M. A. Wilkinson, Simon J. Lloyd-Owen, Gavin C. Donaldson, Mark Wilks, Rodney H. Reznek and Jadwiga A. Wedzicha

Academic Unit of Respiratory Medicine, Academic Radiology, St Bartholomew's and the Royal London Hospital School of Medicine and Dentistry; Microbiology and Virology Clinical Group, St Bartholomew's and the Royal London Hospital NHS Trust, London, United Kingdom

Correspondence and requests for reprints should be addressed to J. A. Wedzicha, M.D., Academic Unit of Respiratory Medicine, Dominion House, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK. E-mail: j.a.wedzicha{at}qmul.ac.uk

Relationships between high-resolution computed tomography (HRCT) findings in chronic obstructive pulmonary disease (COPD) and bacterial colonization, airway inflammation, or exacerbation indices are unknown. Fifty-four patients with COPD (mean [SD]: age, 69 [7] years; FEV1, 0.96 [0.33] L; FEV1 [percent predicted], 38.1 [13.9]%; FEV1/forced vital capacity [percent predicted], 40.9 [11.8]%; arterial partial pressure of oxygen, 8.77 [1.11] kPa; history of smoking, 50.5 [33.5] smoking pack-years) underwent HRCT scans of the chest to quantify the presence and extent of bronchiectasis or emphysema. Exacerbation indices were determined from diary cards over 2 years. Quantitative sputum bacteriology and cytokine measurements were performed. Twenty-seven of 54 patients (50%) had bronchiectasis on HRCT, most frequently in the lower lobes (18 of 54, 33.3%). Patients with bronchiectasis had higher levels of airway inflammatory cytokines (p = 0.001). Lower lobe bronchiectasis was associated with lower airway bacterial colonization (p = 0.004), higher sputum interleukin-8 levels (p = 0.001), and longer symptom recovery time at exacerbation (p = 0.001). No relationship was seen between exacerbation frequency and HRCT changes. Evidence of moderate lower lobe bronchiectasis on HRCT is common in COPD and is associated with more severe COPD exacerbations, lower airway bacterial colonization, and increased sputum inflammatory markers.

Key Words: bronchiectasis • chronic obstructive pulmonary disease • computed tomography scanning • exacerbation • inflammation




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