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Published ahead of print on March 17, 2004, doi:10.1164/rccm.200308-1174OC
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American Journal of Respiratory and Critical Care Medicine Vol 170. pp. 234-241, (2004)
© 2004 American Thoracic Society

Original Article

Progression of Asthma Measured by Lung Function in the Childhood Asthma Management Program

Ronina A. Covar, Joseph D. Spahn, James R. Murphy and Stanley J. Szefler for the Childhood Asthma Management Program Research Group

Ira J. and Jacqueline Neimark Laboratory of Clinical Pharmacology; Department of Pediatrics, Division of Allergy-Clinical Immunology; and Division of Biostatistics, National Jewish Medical and Research Center, Denver, Colorado

Correspondence and requests for reprints should be addressed to Stanley J. Szefler, M.D., National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206. E-mail: szeflers{at}njc.org

From the Childhood Asthma Management Program cohort, which was randomly assigned to receive budesonide, nedocromil, or placebo for 4–6 years, we determined the prevalence of and factors associated with at least 1% per year loss in postbronchodilator FEV1% predicted. Participants who had a significant reduction in postbronchodilator FEV1% predicted (SRP), comprised 25.7% of the cohort (n = 990). Using logistic regression, predictors of SRP at baseline were younger age (p = 0.0005), male sex (p < 0.0001), clinic (p = 0.02), and higher postbronchodilator FEV1% predicted (p = 0.02). Examination of the SRPs indicated that the effect of baseline lung function was such that the higher the lung function, the less steep the reduction in postbronchodilator FEV1% predicted (p < 0.0001). A similar proportion of SRPs was found in each treatment group. Among the SRPs, the rate of reduction in postbronchodilator FEV1% predicted was similar in all treatment groups. At a single site where biomarker assessment was performed, SRPs also had more prominent eosinophilic inflammation during the washout period. The course and mechanisms of lung function reduction or slow lung growth velocity in children with asthma must be defined.

Key Words: asthma progression • markers of inflammation • airway inflammation




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