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Effect of Caffeine Ingestion on Exhaled Nitric Oxide Measurements in Patients with Asthma

Otago Respiratory Research Unit, Dunedin School of Medicine, University of Otago Medical School, Dunedin, New Zealand

Correspondence and requests for reprints should be addressed to D. Robin Taylor, M.D., F.R.C.P.C., Department of Medical and Surgical Sciences, Dunedin School of Medicine, P.O. Box 913, Dunedin, New Zealand. E-mail: robin.taylor{at}stonebow.otago.ac.nz

Exhaled nitric oxide (FE_NO) measurements may be influenced by a number of confounding factors. Reports have offered conflicting evidence as to whether caffeine consumption increases or decreases FE_NO. In this study we aimed to confirm whether caffeine ingestion affects FE_NO in patients with asthma. On two separate days, 20 patients with asthma (10 steroid-naive and 10 steroid-treated) received a standard cup of either caffeinated or noncaffeinated coffee (15 g) (control) in a randomized, double-blind, cross-over manner. FE_NO measurements were obtained at baseline, and 30, 60, 120, and 180 minutes after ingestion. Serum caffeine levels were also measured at 0 and 60 minutes. No significant changes in FE_NO occurred after caffeine compared with the control. We conclude that caffeinated foods and beverages are unlikely to acutely influence FE_NO in subjects with asthma, and protocols for laboratory measurement do not need to take this factor into account.

Key Words: asthma • caffeine • exhaled nitric oxide • measurement

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