help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Published ahead of print on November 3, 2003, doi:10.1164/rccm.200308-1181OC
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200308-1181OCv1
169/4/448    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sethi, S.
Right arrow Articles by Murphy, T. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sethi, S.
Right arrow Articles by Murphy, T. F.
American Journal of Respiratory and Critical Care Medicine Vol 169. pp. 448-453, (2004)
© 2004 American Thoracic Society

Strain-specific Immune Response to Haemophilus influenzae in Chronic Obstructive Pulmonary Disease

Sanjay Sethi, Catherine Wrona, Brydon J. B. Grant and Timothy F. Murphy

Division of Pulmonary and Critical Care Medicine; Division of Infectious Diseases, Department of Medicine; Department of Microbiology, University at Buffalo SUNY; and the Veterans Affairs Western New York Healthcare System, Buffalo, New York

Correspondence and requests for reprints should be addressed to Sanjay Sethi, M.D., VA WNY Healthcare System (151), 3495 Bailey Avenue, Buffalo, NY 14215. E-mail: ssethi{at}buffalo.edu

Previous studies of immune response to Haemophilus influenzae after exacerbations of chronic obstructive pulmonary disease (COPD) have yielded contradictory results. Using homologous (infecting) strains and immunoassays to surface-exposed epitopes, we tested the hypothesis that adults with COPD make new antibodies to strain-specific, surface-exposed epitopes on H. influenzae after exacerbations. We collected clinical information, sputum, and serum monthly and during exacerbations from 81 patients with COPD over 56 months. Serum antibodies to H. influenzae after exacerbations associated with H. influenzae in sputum were detected with whole bacterial cell ELISA and bactericidal assays. An immune response to homologous H. influenzae occurred after 22 of 36 (61.1%) exacerbations with newly acquired strains compared with 7 of 33 (21.2%) exacerbations with preexisting strains (odds ratio [OR] = 4.4; 95%, 1.8 to 10.8; p = 0.001). An absence of an immune response was strongly associated with complement sensitivity (OR = 0.03; 95% confidence interval, 0.003 to 0.22; p = 0.001). New bactericidal antibodies developed after exacerbations were highly strain specific, showing bactericidal activity for only 11 of 90 (12.2%) heterologous strains. Development of an immune response to H. influenzae supports its role in causing exacerbations. The strain specificity of the immune response likely represents a mechanism of recurrent exacerbations.

Key Words: chronic obstructive pulmonary disease • Haemophilus influenzae • humoral immunity • exacerbation




This article has been cited by other articles:


Home page
 NEJMHome page
S. Sethi and T. F. Murphy
Infection in the Pathogenesis and Course of Chronic Obstructive Pulmonary Disease
N. Engl. J. Med., November 27, 2008; 359(22): 2355 - 2365.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. F. Murphy, A. L. Brauer, K. Eschberger, P. Lobbins, L. Grove, X. Cai, and S. Sethi
Pseudomonas aeruginosa in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., April 15, 2008; 177(8): 853 - 860.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
E. A. Ruckdeschel, C. Kirkham, A. J. Lesse, Z. Hu, and T. F. Murphy
Mining the Moraxella catarrhalis Genome: Identification of Potential Vaccine Antigens Expressed during Human Infection
Infect. Immun., April 1, 2008; 76(4): 1599 - 1607.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Sethi, C. Wrona, K. Eschberger, P. Lobbins, X. Cai, and T. F. Murphy
Inflammatory Profile of New Bacterial Strain Exacerbations of Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., March 1, 2008; 177(5): 491 - 497.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
H. Abusriwil and R. A. Stockley
The Interaction of Host and Pathogen Factors in Chronic Obstructive Pulmonary Disease Exacerbations and Their Role in Tissue Damage
Proceedings of the ATS, December 1, 2007; 4(8): 611 - 617.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
E. F. M. Wouters, K. H. Groenewegen, M. A. Dentener, and J. H. J. Vernooy
Systemic Inflammation in Chronic Obstructive Pulmonary Disease: The Role of Exacerbations
Proceedings of the ATS, December 1, 2007; 4(8): 626 - 634.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
A. Sykes, P. Mallia, and S. L. Johnston
Diagnosis of Pathogens in Exacerbations of Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, December 1, 2007; 4(8): 642 - 646.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
A. Anzueto, S. Sethi, and F. J. Martinez
Exacerbations of Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, October 1, 2007; 4(7): 554 - 564.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. F. Rabe, S. Hurd, A. Anzueto, P. J. Barnes, S. A. Buist, P. Calverley, Y. Fukuchi, C. Jenkins, R. Rodriguez-Roisin, C. van Weel, et al.
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease: GOLD Executive Summary
Am. J. Respir. Crit. Care Med., September 15, 2007; 176(6): 532 - 555.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Sethi, R. Sethi, K. Eschberger, P. Lobbins, X. Cai, B. J. B. Grant, and T. F. Murphy
Airway Bacterial Concentrations and Exacerbations of Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., August 15, 2007; 176(4): 356 - 361.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. M. Fernaays, A. J. Lesse, X. Cai, and T. F. Murphy
Characterization of igaB, a Second Immunoglobulin A1 Protease Gene in Nontypeable Haemophilus influenzae.
Infect. Immun., October 1, 2006; 74(10): 5860 - 5870.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
D. C. Look, C. L. Chin, L. J. Manzel, E. E. Lehman, A. L. Humlicek, L. Shi, T. D. Starner, G. M. Denning, T. F. Murphy, and S. Sethi
Modulation of Airway Inflammation by Haemophilus influenzae Isolates Associated with Chronic Obstructive Pulmonary Disease Exacerbation
Proceedings of the ATS, August 1, 2006; 3(6): 482 - 483.
[Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. M. Fernaays, A. J. Lesse, S. Sethi, X. Cai, and T. F. Murphy
Differential Genome Contents of Nontypeable Haemophilus influenzae Strains from Adults with Chronic Obstructive Pulmonary Disease.
Infect. Immun., June 1, 2006; 74(6): 3366 - 3374.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
R Rodriguez-Roisin
COPD exacerbations {middle dot} 5: Management.
Thorax, June 1, 2006; 61(6): 535 - 544.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
R Wilson, P Jones, T Schaberg, P Arvis, I Duprat-Lomon, P P Sagnier, and for the MOSAIC Study Group
Antibiotic treatment and factors influencing short and long term outcomes of acute exacerbations of chronic bronchitis
Thorax, April 1, 2006; 61(4): 337 - 342.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
E Sapey and R A Stockley
COPD exacerbations {middle dot} 2: Aetiology.
Thorax, March 1, 2006; 61(3): 250 - 258.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. Sethi
Coinfection in Exacerbations of COPD: A New Frontier.
Chest, February 1, 2006; 129(2): 223 - 224.
[Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
J. G. Bartlett
Update in Infectious Diseases
Ann Intern Med, January 3, 2006; 144(1): 49 - 56.
[Full Text] [PDF]

Home page
 ERRHome page
G. B. Toews
Impact of bacterial infections on airway diseases
Eur. Respir. Rev., December 1, 2005; 14(95): 62 - 68.
[Abstract] [Full Text] [PDF]

Home page
 ERRHome page
R. Wilson
Treatment of COPD exacerbations: antibiotics
Eur. Respir. Rev., September 1, 2005; 14(94): 32 - 38.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. Wilson
Bacteria and Airway Inflammation in Chronic Obstructive Pulmonary Disease: More Evidence
Am. J. Respir. Crit. Care Med., July 15, 2005; 172(2): 147 - 148.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. L. Chin, L. J. Manzel, E. E. Lehman, A. L. Humlicek, L. Shi, T. D. Starner, G. M. Denning, T. F. Murphy, S. Sethi, and D. C. Look
Haemophilus influenzae from Patients with Chronic Obstructive Pulmonary Disease Exacerbation Induce More Inflammation than Colonizers
Am. J. Respir. Crit. Care Med., July 1, 2005; 172(1): 85 - 91.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. Fabbri, S. P. Peters, I. Pavord, S. E. Wenzel, S. C. Lazarus, W. MacNee, F. Lemaire, and E. Abraham
Allergic Rhinitis, Asthma, Airway Biology, and Chronic Obstructive Pulmonary Disease in AJRCCM in 2004
Am. J. Respir. Crit. Care Med., April 1, 2005; 171(7): 686 - 698.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. F. Murphy and S. Sethi
Are Colonial Haemophilus influenzae Responsible for Exacerbations of Chronic Obstructive Pulmonary Disease After All?
Am. J. Respir. Crit. Care Med., January 15, 2005; 171(2): 194 - 195.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. F. Murphy, A. L. Brauer, A. T. Schiffmacher, and S. Sethi
Persistent Colonization by Haemophilus influenzae in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., August 1, 2004; 170(3): 266 - 272.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. S. Niederman
Does the Presence of Antibodies Justify the Use of Antibiotics in Exacerbations of Chronic Bronchitis?
Am. J. Respir. Crit. Care Med., February 15, 2004; 169(4): 434 - 435.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2004 American Thoracic Society 		  ATS Par News