Published ahead of print on November 20, 2003, doi:10.1164/rccm.200301-055OC
American Journal of Respiratory and Critical Care Medicine Vol 169. pp. 393-398, (2004)
© 2004 American Thoracic Society
Relationship of Serum Antioxidants to Asthma Prevalence in Youth
Rachel N. Rubin,
Livia Navon and
Patricia A. Cassano
Division of Nutritional Sciences, Cornell University, Ithaca, New York
Correspondence and requests for reprints should be addressed to Patricia A. Cassano, B.S., 209 Savage Hall, Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853. E-mail: pac6{at}cornell.edu
The relationship of serum vitamin E, ß-carotene, vitamin C, and selenium to asthma was investigated among 7,505 youth (4–16 years old) in the Third National Health and Nutrition Examination Survey. Logistic regression models adjusted for potentially confounding variables, which generally had no effect on the coefficients for the antioxidants. Serum vitamin E had little or no association with asthma. In separate models, a SD increase in ß-carotene (odds ratio [OR], 0.9; 95% confidence interval [CI], 0.7, 1.0), vitamin C (OR, 0.8; 95% CI, 0.7, 0.9), and selenium (OR, 0.9; 95% CI, 0.7, 1.1) was associated with a 10–20% reduction in asthma prevalence. Serum cotinine was used to identify youth with no cigarette smoke exposure and passive exposure (7%): Active smokers were too few to be studied further. The selenium–asthma association was stronger in youth who were smoke exposed (p = 0.075). A SD increase in selenium was associated with a 50% reduction in asthma prevalence (OR, 0.5; 95% CI, 0.2, 1.4) in youth with passive smoke exposure compared with a 10% reduction in youth with no smoke exposure. The findings support an association of antioxidants with prevalent asthma, which for some antioxidants is stronger among children exposed to cigarette smoke.
Key Words: antioxidants • asthma • child • second-hand smoke
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