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Published ahead of print on November 3, 2003, doi:10.1164/rccm.200306-800OC
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American Journal of Respiratory and Critical Care Medicine Vol 169. pp. 209-213, (2004)
© 2004 American Thoracic Society

Interrupter Resistance and Wheezing Phenotypes at 4 Years of Age

Jessica E. Brussee, Henriëtte A. Smit, Laurens P. Koopman, Alet H. Wijga, Marjan Kerkhof, Karen Corver, Ada P. H. Vos, Jorrit Gerritsen, Diederick E. Grobbee, Bert Brunekreef, Peter J. F. M. Merkus and Johan C. de Jongste

Center for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven; Division of Respiratory Medicine, Department of Pediatrics, Sophia's Children's Hospital, Erasmus University Medical Center, Rotterdam; Department of Epidemiology and Statistics, University of Groningen, Groningen; Institute for Risk Assessment Sciences, Utrecht University, Utrecht; Department of Paediatric Respiratory Medicine, University Hospital Groningen, Groningen; and Julius Center for Health Sciences and Primary Care, Utrecht University Medical Center, Utrecht, The Netherlands

Correspondence and requests for reprints should be addressed to Henriëtte A. Smit, Ph.D., National Institute for Public Health and the Environment (RIVM), Center for Prevention and Health Services Research, P.O. Box 1, 3720 BA Bilthoven, The Netherlands. E-mail: jet.smit{at}rivm.nl

It is difficult to distinguish young children with respiratory symptoms who will develop asthma from those with transient symptoms only. Measurement of interrupter resistance may help to identify children at high risk of asthma. The aim of this study is to compare interrupter resistance in 4-year-old children with different wheezing phenotypes. All children participated in the Prevention and Incidence of Asthma and Mite Allergy cohort, a prospective birth cohort of more than 4,000 children. At 4 years of age, data on interrupter resistance plus wheezing phenotype were available for 838 children. Mean interrupter resistance values (95% confidence interval) were 0.95 (0.93, 0.97), 0.95 (0.92, 0.98), 0.96 (0.87, 1.05), and 1.08 (1.02, 1.14) kPa · L-1 · second for never (n = 482), early transient (n = 236), late-onset (n = 22), and persistent (n = 98) wheezing phenotypes, respectively. Additional analyses were performed for children with atopic and nonatopic mothers separately. Both in children with atopic and nonatopic mothers, children with persistent wheeze had significantly higher interrupter resistance values than children with never and early wheeze. In conclusion, mean interrupter resistance values were higher in children with persistent wheeze as compared with children with never and early transient wheezing phenotypes.

Key Words: allergy • asthma • child, preschool • cohort studies




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