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Published ahead of print on September 18, 2003, doi:10.1164/rccm.200210-1234OC
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American Journal of Respiratory and Critical Care Medicine Vol 169. pp. 27-33, (2004)
© 2004 American Thoracic Society

Laminin-5 {gamma}2 Chain in Cryptogenic Organizing Pneumonia and Idiopathic Pulmonary Fibrosis

Elisa Lappi-Blanco, Riitta Kaarteenaho-Wiik, Sirpa Salo, Raija Sormunen, Marko Määttä, Helena Autio-Harmainen, Ylermi Soini and Paavo Pääkkö

Departments of Pathology, Internal Medicine, and Biochemistry, University of Oulu and Oulu University Hospital, and Biocenter Oulu, Oulu, Finland

Correspondence and requests for reprints should be addressed to Elisa Lappi-Blanco, M.D., Ph.D., Department of Pathology, University of Oulu, P.O. Box 5000, FIN-90014 Oulu, Finland. E-mail: elisa.lappi-blanco{at}oulu.fi

Insufficient reepithelialization of injured alveolar walls may be important in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Laminin-5 is expressed in epithelial cells of healing wounds, promoting cell attachment and migration. In this study we have studied the extent of reepithelialization of newly formed intraluminal connective tissue, the immunohistochemical expression and ultrastructural localization of the laminin-5 {gamma}2 chain protein, and the synthesis of the laminin-5 {gamma}2 chain mRNA in regenerating epithelial cells in cryptogenic organizing pneumonia (COP) and IPF. The results show that the mean extent of reepithelialization of intraluminal connective tissue lesions was 76% (SD, ± 27%) in COP, and 54% (SD, ± 23%) in IPF (p < 0.025). The laminin-5 {gamma}2 chain was synthesized and widely expressed in regenerating epithelial cells in both diseases. Immunohistochemistry for surfactant-associated protein A suggests a pneumocyte origin for the regenerating epithelial cells in IPF. It is concluded that both in COP and IPF, regenerating epithelial cells are capable of synthesizing the laminin-5 {gamma}2 chain needed for adhesive connections to the underlying basement membrane. However, in IPF, the reepithelialization seems to be disturbed or delayed.

Key Words: alveolar epithelium • cryptogenic organizing pneumonia • idiopathic pulmonary fibrosis • laminin-5 • pulmonary fibrosis




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