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Published ahead of print on October 2, 2003, doi:10.1164/rccm.200302-239OC
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American Journal of Respiratory and Critical Care Medicine Vol 169. pp. 105-112, (2004)
© 2004 American Thoracic Society

Roles of Fc{gamma}RIIB in Nasal Eosinophilia and IgE Production in Murine Allergic Rhinitis

Tohru Watanabe, Mitsuhiro Okano, Hisashi Hattori, Tadashi Yoshino, Nobuaki Ohno, Nobuo Ohta, Yuji Sugata, Yorihisa Orita, Toshiyuki Takai and Kazunori Nishizaki

Departments of Otolaryngology-Head and Neck Surgery, and Pathology, Okayama University Graduate School of Medicine and Dentistry, Okayama; Department of Otolaryngology and Medical Zoology, Nagoya City University Medical School, Nagoya; and Department of Experimental Immunology, Institute of Development, Aging, and Cancer, Sendai, Japan

Correspondence and requests for reprints should be addressed to Mitsuhiro Okano, M.D., Ph.D., Department of Otolaryngology-Head and Neck Surgery, Okayama University Medical School, 2-5-1 Shikatacho, Okayama 700–8558, Japan. E-mail: mokano{at}cc.okayama-u.ac.jp

The low-affinity IgG Fc receptor, Fc{gamma}RIIB, displays inhibitory potential in experimental models such as autoimmune diseases. However, whether this receptor is involved in the onset of allergic diseases remains unknown. This study examines the role of Fc{gamma}RIIB in the initiation of allergic rhinitis in mice. Repeated intranasal sensitization with Schistosoma mansoni egg antigen (SEA) induced SEA-specific IgE and marked nasal eosinophilia in high-responder BALB/c mice. Fc{gamma}RIIB gene-deficient (-/-) BALB/c mice displayed severe eosinophilia compared with that of wild-type counterparts. However, Fc{gamma}RIIB -/- mice conversely produced less SEA-specific IgE. The production of interleukin (IL)-4 but not of IL-5 or IFN-{gamma} by nasal mononuclear cells was also decreased in Fc{gamma}RIIB -/- mice, suggesting that the exacerbation of nasal eosinophila in Fc{gamma}RIIB -/- mice is independent of the local IL-5 levels. The findings in low responder C57BL/6 mice were similar. In addition, nasal eosinophilia in Fc{gamma}RIIB -/- mice passively sensitized with SEA was exacerbated, and conversely, specific IgE production was inhibited after a nasal challenge. These results suggest that Fc{gamma}RIIB plays a regulatory role in the initiation of allergic rhinitis that is independent of either mouse strain or type of sensitization.

Key Words: Fc receptor • rhinitis • mouse • IgE • eosinophil




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