help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Published ahead of print on August 13, 2003, doi:10.1164/rccm.200302-219OC
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200302-219OCv1
168/9/1084    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lama, V. N.
Right arrow Articles by Martinez, F. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lama, V. N.
Right arrow Articles by Martinez, F. J.
American Journal of Respiratory and Critical Care Medicine Vol 168. pp. 1084-1090, (2003)
© 2003 American Thoracic Society

Prognostic Value of Desaturation during a 6-Minute Walk Test in Idiopathic Interstitial Pneumonia

Vibha N. Lama, Kevin R. Flaherty, Galen B. Toews, Thomas V. Colby, William D. Travis, Qi Long, Susan Murray, Ella A. Kazerooni, Barry H. Gross, Joseph P. Lynch, III and Fernando J. Martinez

Division of Pulmonary and Critical Care Medicine and Department of Radiology, University of Michigan Health System; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan; and the Armed Forces Institute of Pathology, Mayo Clinic, Scottsdale, Arizona

Correspondence and requests for reprints should be addressed to Fernando J. Martinez, M.D., M.S., 1500 East Medical Center Drive, 3916 Taubman Center, Ann Arbor, MI 48109–0360. E-mail: fmartine{at}umich.edu

Exercise-induced hypoxia is an index of the severity of interstitial lung disease. We hypothesized that desaturation during a 6-minute walk test would predict mortality for patients with usual interstitial pneumonia (n = 83) and nonspecific interstitial pneumonia (n = 22). Consecutive patients with biopsy-proven disease performed a 6-minute walk test between January 1996 and December 2001. Desaturation was defined as a fall in oxygen saturation to 88% or less during the 6-minute walk test. Desaturation was common (44 of 83 usual interstitial pneumonia and 8 of 22 nonspecific interstitial pneumonia; chi square, p = 0.39). Patients with usual interstitial pneumonia or nonspecific interstitial pneumonia who desaturated had a significantly higher mortality than patients who did not desaturate (respective log-rank tests, p = 0.0018, p = 0.0089). In patients with usual interstitial pneumonia, the presence of desaturation was associated with an increased hazard of death (hazard ratio, 4.2; 95% confidence interval, 1.40, 12.56; p = 0.01) after adjusting for age, sex, smoking, baseline diffusion capacity for carbon monoxide, FVC, and resting saturation. We conclude that knowledge of desaturation during a 6-minute walk test adds prognostic information for patients with usual interstitial pneumonia and nonspecific interstitial pneumonia.

Key Words: 6-minute walk test • usual interstitial pneumonia • nonspecific interstitial pneumonia




This article has been cited by other articles:


Home page
 ThoraxHome page
T J Corte, S J Wort, M A Gatzoulis, P Macdonald, D M Hansell, and A U Wells
Pulmonary vascular resistance predicts early mortality in patients with diffuse fibrotic lung disease and suspected pulmonary hypertension
Thorax, October 1, 2009; 64(10): 883 - 888.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. J. Swigris, J. Swick, F. S. Wamboldt, D. Sprunger, R. du Bois, A. Fischer, G. P. Cosgrove, S. K. Frankel, E. R. Fernandez-Perez, D. Kervitsky, et al.
Heart Rate Recovery After 6-Min Walk Test Predicts Survival in Patients With Idiopathic Pulmonary Fibrosis
Chest, September 1, 2009; 136(3): 841 - 848.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J J Swigris, X Zhou, F S Wamboldt, R du Bois, R Keith, A Fischer, G P Cosgrove, S K Frankel, D Curran-Everett, and K K Brown
Exercise peripheral oxygen saturation (Spo2) accurately reflects arterial oxygen saturation (Sao2) and predicts mortality in systemic sclerosis
Thorax, July 1, 2009; 64(7): 626 - 630.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
A. U. Wells, V. Steen, and G. Valentini
Pulmonary complications: one of the most challenging complications of systemic sclerosis
Rheumatology, June 1, 2009; 48(suppl_3): iii40 - iii44.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Prasse, C. Probst, E. Bargagli, G. Zissel, G. B. Toews, K. R. Flaherty, M. Olschewski, P. Rottoli, and J. Muller-Quernheim
Serum CC-Chemokine Ligand 18 Concentration Predicts Outcome in Idiopathic Pulmonary Fibrosis
Am. J. Respir. Crit. Care Med., April 15, 2009; 179(8): 717 - 723.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
K. M. Antoniou, G. Margaritopoulos, F. Economidou, and N. M. Siafakas
Pivotal clinical dilemmas in collagen vascular diseases associated with interstitial lung involvement
Eur. Respir. J., April 1, 2009; 33(4): 882 - 896.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Moeller, S. E. Gilpin, K. Ask, G. Cox, D. Cook, J. Gauldie, P. J. Margetts, L. Farkas, J. Dobranowski, C. Boylan, et al.
Circulating Fibrocytes Are an Indicator of Poor Prognosis in Idiopathic Pulmonary Fibrosis
Am. J. Respir. Crit. Care Med., April 1, 2009; 179(7): 588 - 594.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. D. Fell, L. X. Liu, C. Motika, E. A. Kazerooni, B. H. Gross, W. D. Travis, T. V. Colby, S. Murray, G. B. Toews, F. J. Martinez, et al.
The Prognostic Value of Cardiopulmonary Exercise Testing in Idiopathic Pulmonary Fibrosis
Am. J. Respir. Crit. Care Med., March 1, 2009; 179(5): 402 - 407.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
M. Kreider and R. M. Kotloff
Selection of Candidates for Lung Transplantation
Proceedings of the ATS, January 15, 2009; 6(1): 20 - 27.
[Abstract] [Full Text] [PDF]

Home page
 ACCP Pulmonary Med Brd RevHome page
J. P. Lynch III
Idiopathic Pulmonary Fibrosis, Nonspecific Interstitial Pneumonia/Fibrosis, and Sarcoidosis
ACCP Pulmonary Med Brd Rev, January 1, 2009; 25(0): 635 - 686.
[Full Text] [PDF]

Home page
 Ther Adv Respir DisHome page
R. Kim and K. C. Meyer
Review: Therapies for interstitial lung disease: past, present and future
Therapeutic Advances in Respiratory Disease, October 1, 2008; 2(5): 319 - 338.
[Abstract] [PDF]

Home page
 ChestHome page
C. Casanova, C. Cote, J. M. Marin, V. Pinto-Plata, J. P. de Torres, A. Aguirre-Jaime, C. Vassaux, and B. R. Celli
Distance and Oxygen Desaturation During the 6-min Walk Test as Predictors of Long-term Mortality in Patients With COPD
Chest, October 1, 2008; 134(4): 746 - 752.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
K. M. Shin, K. S. Lee, M. P. Chung, J. Han, Y. A Bae, T. S. Kim, and M. J. Chung
Prognostic Determinants among Clinical, Thin-Section CT, and Histopathologic Findings for Fibrotic Idiopathic Interstitial Pneumonias: Tertiary Hospital Study1
Radiology, October 1, 2008; 249(1): 328 - 337.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
A U Wells, N Hirani, and on behalf of the BTS Interstitial Lung Disease Gui
Interstitial lung disease guideline
Thorax, September 1, 2008; 63(Suppl_5): v1 - v58.
[Full Text] [PDF]

Home page
 RadiologyHome page
K. M. Shin, K. S. Lee, M. P. Chung, J. Han, Y. A Bae, T. S. Kim, and M. J. Chung
Prognostic Determinants among Clinical, Thin-Section CT, and Histopathologic Findings for Fibrotic Idiopathic Interstitial Pneumonias: Tertiary Hospital Study
Radiology, August 5, 2008; (2008) 2483071378.
[Abstract] [Full Text]

Home page
 Eur Respir JHome page
J. M. Bourbonnais and L. Samavati
Clinical predictors of pulmonary hypertension in sarcoidosis
Eur. Respir. J., August 1, 2008; 32(2): 296 - 302.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. K. Han, S. Murray, C. D. Fell, K. R. Flaherty, G. B. Toews, J. Myers, T. V. Colby, W. D. Travis, E. A. Kazerooni, B. H. Gross, et al.
Sex differences in physiological progression of idiopathic pulmonary fibrosis
Eur. Respir. J., June 1, 2008; 31(6): 1183 - 1188.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. Strange and J. R. Seibold
Scleroderma Lung Disease: "If You Don't Know Where You Are Going, Any Road Will Take You There"
Am. J. Respir. Crit. Care Med., June 1, 2008; 177(11): 1178 - 1179.
[Full Text] [PDF]

Home page
 ThoraxHome page
A E Holland, C J Hill, M Conron, P Munro, and C F McDonald
Short term improvement in exercise capacity and symptoms following exercise training in interstitial lung disease
Thorax, June 1, 2008; 63(6): 549 - 554.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
G. Giannakoulas, T. D. Karamitsos, G. Pitsiou, and H. I. Karvounis
Right ventricular dysfunction and functional limitation in idiopathic pulmonary fibrosis
Eur. Respir. J., January 1, 2008; 31(1): 219 - 220.
[Full Text] [PDF]

Home page
 CirculationHome page
M. K. Han, V. V. McLaughlin, G. J. Criner, and F. J. Martinez
Pulmonary Diseases and the Heart
Circulation, December 18, 2007; 116(25): 2992 - 3005.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. A. Zisman, A. S. Karlamangla, D. J. Ross, M. P. Keane, J. A. Belperio, R. Saggar, J. P. Lynch III, A. Ardehali, and J. Goldin
High-Resolution Chest CT Findings Do Not Predict the Presence of Pulmonary Hypertension in Advanced Idiopathic Pulmonary Fibrosis
Chest, September 1, 2007; 132(3): 773 - 779.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
I. Noth and F. J. Martinez
Recent Advances in Idiopathic Pulmonary Fibrosis
Chest, August 1, 2007; 132(2): 637 - 650.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
R. P. Baughman, B. K. Sparkman, and E. E. Lower
Six-Minute Walk Test and Health Status Assessment in Sarcoidosis
Chest, July 1, 2007; 132(1): 207 - 213.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. R. Flaherty, A.-C. Andrei, T. E. King Jr., G. Raghu, T. V. Colby, A. Wells, N. Bassily, K. Brown, R. du Bois, A. Flint, et al.
Idiopathic Interstitial Pneumonia: Do Community and Academic Physicians Agree on Diagnosis?
Am. J. Respir. Crit. Care Med., May 15, 2007; 175(10): 1054 - 1060.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. D. Nathan, P. W. Noble, and R. M. Tuder
Idiopathic Pulmonary Fibrosis and Pulmonary Hypertension: Connecting the Dots
Am. J. Respir. Crit. Care Med., May 1, 2007; 175(9): 875 - 880.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. U. Wells and C. M. Hogaboam
Update in Diffuse Parenchymal Lung Disease 2006
Am. J. Respir. Crit. Care Med., April 1, 2007; 175(7): 655 - 660.
[Full Text] [PDF]

Home page
 ChestHome page
C. D. Fell and F. J. Martinez
The Impact of Pulmonary Arterial Hypertension on Idiopathic Pulmonary Fibrosis
Chest, March 1, 2007; 131(3): 641 - 643.
[Full Text] [PDF]

Home page
 ChestHome page
K. Hamada, S. Nagai, S. Tanaka, T. Handa, M. Shigematsu, T. Nagao, M. Mishima, M. Kitaichi, and T. Izumi
Significance of Pulmonary Arterial Pressure and Diffusion Capacity of the Lung as Prognosticator in Patients With Idiopathic Pulmonary Fibrosis
Chest, March 1, 2007; 131(3): 650 - 656.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S. Dal Corso, S. R. Duarte, J. A. Neder, C. Malaguti, M. B. de Fuccio, C. A. de Castro Pereira, and L. E. Nery
A step test to assess exercise-related oxygen desaturation in interstitial lung disease
Eur. Respir. J., February 1, 2007; 29(2): 330 - 336.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. Palange, S. A. Ward, K-H. Carlsen, R. Casaburi, C. G. Gallagher, R. Gosselink, D. E. O'Donnell, L. Puente-Maestu, A. M. Schols, S. Singh, et al.
Recommendations on the use of exercise testing in clinical practice
Eur. Respir. J., January 1, 2007; 29(1): 185 - 209.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
W. O. Villalba, P. D. Sampaio-Barros, M. C. Pereira, E. M. F. P. Cerqueira, C. A. Leme Jr, J. F. Marques-Neto, and I. A. Paschoal
Six-Minute Walk Test for the Evaluation of Pulmonary Disease Severity in Scleroderma Patients
Chest, January 1, 2007; 131(1): 217 - 222.
[Abstract] [Full Text] [PDF]

Home page
 QJMHome page
O.J. Dempsey, K.M. Kerr, L. Gomersall, H. Remmen, and G.P. Currie
Idiopathic pulmonary fibrosis: an update
QJM, October 1, 2006; 99(10): 643 - 654.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. R. Flaherty, A.-C. Andrei, S. Murray, C. Fraley, T. V. Colby, W. D. Travis, V. Lama, E. A. Kazerooni, B. H. Gross, G. B. Toews, et al.
Idiopathic Pulmonary Fibrosis: Prognostic Value of Changes in Physiology and Six-Minute-Walk Test
Am. J. Respir. Crit. Care Med., October 1, 2006; 174(7): 803 - 809.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. J. Lederer, S. M. Arcasoy, J. S. Wilt, F. D'Ovidio, J. R. Sonett, and S. M. Kawut
Six-Minute-Walk Distance Predicts Waiting List Survival in Idiopathic Pulmonary Fibrosis
Am. J. Respir. Crit. Care Med., September 15, 2006; 174(6): 659 - 664.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. L. Croxton, W. C. Bailey, and for the NHLBI Working Group on Long-term Oxygen Tr
Long-term Oxygen Treatment in Chronic Obstructive Pulmonary Disease: Recommendations for Future Research: An NHLBI Workshop Report
Am. J. Respir. Crit. Care Med., August 15, 2006; 174(4): 373 - 378.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. J. Martinez and M. P. Keane
Update in diffuse parenchymal lung diseases 2005.
Am. J. Respir. Crit. Care Med., May 15, 2006; 173(10): 1066 - 1071.
[Full Text] [PDF]

Home page
 ChestHome page
C. J. Lettieri, S. D. Nathan, S. D. Barnett, S. Ahmad, and A. F. Shorr
Prevalence and Outcomes of Pulmonary Arterial Hypertension in Advanced Idiopathic Pulmonary Fibrosis
Chest, March 1, 2006; 129(3): 746 - 752.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
G. Raghu, S. T.-Y. Yang, C. Spada, J. Hayes, and C. A. Pellegrini
Sole Treatment of Acid Gastroesophageal Reflux in Idiopathic Pulmonary Fibrosis: A Case Series
Chest, March 1, 2006; 129(3): 794 - 800.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
F. J. Martinez
Idiopathic Interstitial Pneumonias: Usual Interstitial Pneumonia versus Nonspecific Interstitial Pneumonia.
Proceedings of the ATS, January 1, 2006; 3(1): 81 - 95.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
D. S. Kim, H. R. Collard, and T. E. King Jr.
Classification and natural history of the idiopathic interstitial pneumonias.
Proceedings of the ATS, January 1, 2006; 3(4): 285 - 292.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
F. J. Martinez and K. Flaherty
Pulmonary function testing in idiopathic interstitial pneumonias.
Proceedings of the ATS, January 1, 2006; 3(4): 315 - 321.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
M. Demedts, J. Behr, R. Buhl, U. Costabel, R. Dekhuijzen, H. M. Jansen, W. MacNee, M. Thomeer, B. Wallaert, F. Laurent, et al.
High-Dose Acetylcysteine in Idiopathic Pulmonary Fibrosis.
N. Engl. J. Med., November 24, 2005; 353(21): 2229 - 2242.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
W. C. Johnson and G. Raghu
Clinical trials in idiopathic pulmonary fibrosis: a word of caution concerning choice of outcome measures
Eur. Respir. J., November 1, 2005; 26(5): 755 - 758.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. Raghu
Poor Choice of Primary Outcome in a Clinical Trial of Pirfenidone in Patients with IPF
Am. J. Respir. Crit. Care Med., November 1, 2005; 172(9): 1229 - 1230.
[Full Text] [PDF]

Home page
 ChestHome page
S. D. Nathan
Therapeutic Intervention: Assessing the Role of the International Consensus Guidelines
Chest, November 1, 2005; 128(5_suppl_1): 533S - 539S.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
P. W. Noble, L. Tanoue, and R. Homer
Case Study Review
Chest, November 1, 2005; 128(5_suppl_1): 540S - 546S.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. Strange
Treatment for Secondary Pulmonary Hypertension
Chest, October 1, 2005; 128(4): 1897 - 1898.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Eaton, P. Young, D. Milne, and A. U. Wells
Six-Minute Walk, Maximal Exercise Tests: Reproducibility in Fibrotic Interstitial Pneumonia
Am. J. Respir. Crit. Care Med., May 15, 2005; 171(10): 1150 - 1157.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. M. du Bois
Is Idiopathic Pulmonary Fibrosis Now Treatable?
Am. J. Respir. Crit. Care Med., May 1, 2005; 171(9): 939 - 940.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Azuma, T. Nukiwa, E. Tsuboi, M. Suga, S. Abe, K. Nakata, Y. Taguchi, S. Nagai, H. Itoh, M. Ohi, et al.
Double-blind, Placebo-controlled Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis
Am. J. Respir. Crit. Care Med., May 1, 2005; 171(9): 1040 - 1047.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J J Egan, F J Martinez, A U Wells, and T Williams
Lung function estimates in idiopathic pulmonary fibrosis: the potential for a simple classification
Thorax, April 1, 2005; 60(4): 270 - 273.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Y. Jegal, D. S. Kim, T. S. Shim, C.-M. Lim, S. Do Lee, Y. Koh, W. S. Kim, W. D. Kim, J. S. Lee, W. D. Travis, et al.
Physiology Is a Stronger Predictor of Survival than Pathology in Fibrotic Interstitial Pneumonia
Am. J. Respir. Crit. Care Med., March 15, 2005; 171(6): 639 - 644.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. D. Nathan
Lung Transplantation: Disease-Specific Considerations for Referral
Chest, March 1, 2005; 127(3): 1006 - 1016.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T. S. Hallstrand, L. J. Boitano, W. C. Johnson, C. A. Spada, J. G. Hayes, and G. Raghu
The timed walk test as a measure of severity and survival in idiopathic pulmonary fibrosis
Eur. Respir. J., January 1, 2005; 25(1): 96 - 103.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. J. Swigris, W. G. Kuschner, J. L. Kelsey, and M. K. Gould
Idiopathic Pulmonary Fibrosis: Challenges and Opportunities for the Clinician and Investigator
Chest, January 1, 2005; 127(1): 275 - 283.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. R. Flaherty, T. E. King Jr., G. Raghu, J. P. Lynch III, T. V. Colby, W. D. Travis, B. H. Gross, E. A. Kazerooni, G. B. Toews, Q. Long, et al.
Idiopathic Interstitial Pneumonia: What Is the Effect of a Multidisciplinary Approach to Diagnosis?
Am. J. Respir. Crit. Care Med., October 15, 2004; 170(8): 904 - 910.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Tuberculosis, Lung Infections, Interstitial Lung Disease, Social Issues and Journalology in AJRCCM 2003
Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 288 - 300.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2003 American Thoracic Society 		  CCM abstracts