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Cough Gastric Pressure and Maximum Expiratory Mouth Pressure in Humans

Respiratory Muscle Laboratory, Guy's King's and St. Thomas' School of Medicine, King's College Hospital; and Royal Brompton Hospital, London, United Kingdom

Correspondence and requests for reprints should be addressed to William Man, BSc (Hon), MBBS (Hon), MRCP, Respiratory Muscle Laboratory, Department of Respiratory Medicine, King's College Hospital, Bessemer Road, London SE5 9PJ, UK. E-mail: william.man{at}kcl.ac.uk

Maximal expiratory mouth pressure is a well established test that is used to assess expiratory muscle strength. However, low values are difficult to interpret, as they may result from technical difficulties in performing the test, particularly in patients with facial muscle weakness or bulbar dysfunction. We hypothesized that measuring the gastric pressure during a cough, a natural maneuver recruiting the expiratory muscles, might prove to be a useful additional test in the assessment of expiratory muscle function. Mouth expiratory and cough gastric pressures were measured in 99 healthy volunteers to obtain normal values and in 293 patients referred for respiratory muscle assessment to compare the two measurements. Between-occasion within-subject coefficient of variation, assessed in 24 healthy volunteers, was 10.3% for mouth pressure and 6.9% for cough. Mean ± SD cough gastric pressure for normal males was 214.4 ± 42.2 and 165.1 ± 34.8 cm H₂O for females. In 171 patients deemed weak by a low mouth expiratory pressure, 42% had a normal cough gastric pressure. In 105 patients deemed weak by a low cough gastric pressure, 5.7% had a normal expiratory mouth pressure. Low maximal expiratory mouth pressures do not always indicate expiratory muscle weakness. Cough gastric pressure provides a useful complementary test for the assessment of expiratory muscle strength.

Key Words: respiratory muscles • neuromuscular disease • abdominal muscles

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