help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Published ahead of print on September 18, 2003, doi:10.1164/rccm.200303-374OC
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200303-374OCv1
168/11/1317    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Murphy, V. E.
Right arrow Articles by Clifton, V. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Murphy, V. E.
Right arrow Articles by Clifton, V. L.
American Journal of Respiratory and Critical Care Medicine Vol 168. pp. 1317-1323, (2003)
© 2003 American Thoracic Society

Maternal Asthma Is Associated with Reduced Female Fetal Growth

Vanessa E. Murphy, Peter G. Gibson, Warwick B. Giles, Tamas Zakar, Roger Smith, Andrew M. Bisits, Carolyn G. Kessell and Vicki L. Clifton

Mothers and Babies Research Centre; and Department of Respiratory and Sleep Medicine, John Hunter Hospital, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW, Australia

Correspondence and requests for reprints should be addressed to Vicki Clifton, B.Sc. (Hons), Ph.D., Mothers and Babies Research Centre, Department of Endocrinology, John Hunter Hospital, Locked Bag 1, HRMC, Newcastle, NSW 2310, Australia. E-mail: vclifton{at}mail.newcastle.edu.au

Asthma during pregnancy is associated with a low birth weight, although the mechanisms contributing to this outcome remain unknown. The relationship between maternal asthma and its treatment, placental function, fetal sex, and low birth weight was examined to establish the effect of asthma on fetal growth. Glucocorticoid intake by women with asthma was assessed throughout pregnancy. The placenta was collected after delivery, and 11ß-hydroxysteroid dehydrogenase type 2 (11ß-HSD2) activity was measured. Fetal cortisol and estriol were measured in the umbilical vein plasma at delivery. Those with asthma were compared with a nonasthmatic control group. In women with asthma who did not use inhaled steroids and were pregnant with a female fetus, we observed significantly reduced birth weights, whereas male birth weights were unaffected. The presence of a female fetus was associated with significantly increased maternal circulating monocytes, significantly reduced placental 11ß-HSD2 activity and fetal estriol, and a trend toward elevated fetal plasma cortisol. This study provides evidence that in pregnancies complicated by asthma there is a fetal sex-specific effect on the maternal immune system with adverse effects on placental function and female fetal growth.

Key Words: asthma • pregnancy • placenta • fetal growth • 11ß-hydroxysteroid dehydrogenase type 2




This article has been cited by other articles:


Home page
 Endocr. Rev.Home page
M. Tegethoff, C. Pryce, and G. Meinlschmidt
Effects of Intrauterine Exposure to Synthetic Glucocorticoids on Fetal, Newborn, and Infant Hypothalamic-Pituitary-Adrenal Axis Function in Humans: A Systematic Review
Endocr. Rev., December 1, 2009; 30(7): 753 - 789.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. Braun, S. Li, D. M. Sloboda, W. Li, M. C. Audette, T. J. M. Moss, S. G. Matthews, G. Polglase, I. Nitsos, J. P. Newnham, et al.
Effects of Maternal Dexamethasone Treatment in Early Pregnancy on Pituitary-Adrenal Axis in Fetal Sheep
Endocrinology, December 1, 2009; 150(12): 5466 - 5477.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
V Mericq, P Medina, E Kakarieka, L Marquez, M C Johnson, and G Iniguez
Differences in expression and activity of 11{beta}-hydroxysteroid dehydrogenase type 1 and 2 in human placentas of term pregnancies according to birth weight and gender
Eur. J. Endocrinol., September 1, 2009; 161(3): 419 - 425.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. J. Stark, I. M. R. Wright, and V. L. Clifton
Sex-specific alterations in placental 11{beta}-hydroxysteroid dehydrogenase 2 activity and early postnatal clinical course following antenatal betamethasone
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2009; 297(2): R510 - R514.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. S. Wyrwoll, J. R. Seckl, and M. C. Holmes
Altered Placental Function of 11{beta}-Hydroxysteroid Dehydrogenase 2 Knockout Mice
Endocrinology, March 1, 2009; 150(3): 1287 - 1293.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. M. Scott, N. A. Hodyl, V. E. Murphy, A. Osei-Kumah, H. Wyper, D. M. Hodgson, R. Smith, and V. L. Clifton
Placental Cytokine Expression Covaries with Maternal Asthma Severity and Fetal Sex
J. Immunol., February 1, 2009; 182(3): 1411 - 1420.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. F. Johnson, N. Rennie, V. Murphy, T. Zakar, V. Clifton, and R. Smith
Expression of Glucocorticoid Receptor Messenger Ribonucleic Acid Transcripts in the Human Placenta at Term
J. Clin. Endocrinol. Metab., December 1, 2008; 93(12): 4887 - 4893.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Buss, C. Lord, M. Wadiwalla, D. H. Hellhammer, S. J. Lupien, M. J. Meaney, and J. C. Pruessner
Maternal Care Modulates the Relationship between Prenatal Risk and Hippocampal Volume in Women But Not in Men
J. Neurosci., March 7, 2007; 27(10): 2592 - 2595.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
M. J. Stark, L. Dierkx, V. L. Clifton, and I. M. R. Wright
Alterations in the Maternal Peripheral Microvascular Response in Pregnancies Complicated by Preeclampsia and the Impact of Fetal Sex
Reproductive Sciences, December 1, 2006; 13(8): 573 - 578.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
H. N. Jones, C. J. Ashworth, K. R. Page, and H. J. McArdle
Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo)
Am J Physiol Endocrinol Metab, September 1, 2006; 291(3): E596 - E603.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
V. E. Murphy, R. Smith, W. B. Giles, and V. L. Clifton
Endocrine Regulation of Human Fetal Growth: The Role of the Mother, Placenta, and Fetus
Endocr. Rev., April 1, 2006; 27(2): 141 - 169.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
H. L. Kwon, K. Belanger, T. R. Holford, and M. B. Bracken
Effect of Fetal Sex on Airway Lability in Pregnant Women with Asthma
Am. J. Epidemiol., February 1, 2006; 163(3): 217 - 221.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
V. E. Murphy, P. G. Gibson, P. I. Talbot, C. G. Kessell, and V. L. Clifton
Asthma self-management skills and the use of asthma education during pregnancy
Eur. Respir. J., September 1, 2005; 26(3): 435 - 441.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
V. E. Murphy, R. F. Johnson, Y.-C. Wang, K. Akinsanya, P. G. Gibson, R. Smith, and V. L. Clifton
The Effect of Maternal Asthma on Placental and Cord Blood Protein Profiles
Reproductive Sciences, July 1, 2005; 12(5): 349 - 355.
[Abstract] [PDF]

Home page
 Eur Respir JHome page
V. E. Murphy, P. G. Gibson, R. Smith, and V. L. Clifton
Asthma during pregnancy: mechanisms and treatment implications
Eur. Respir. J., April 1, 2005; 25(4): 731 - 750.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Asthma, Airway Biology, and Nasal Disorders in AJRCCM 2003
Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 265 - 276.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Pediatrics, Surfactant, and Cystic Fibrosis in AJRCCM 2003
Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 277 - 287.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2003 American Thoracic Society 		  New Orleans Int'l Conf