American Journal of Respiratory and Critical Care Medicine Vol 168. pp. 1277-1292, (2003)
© 2003 American Thoracic Society
Bronchiolar Disorders
Jay H. Ryu,
Jeffrey L. Myers and
Stephen J. Swensen
Division of Pulmonary and Critical Care Medicine; Department of Laboratory Medicine and Pathology; and Department of Radiology, Mayo Clinic, Rochester, Minnesota
Correspondence and requests for reprints should be addressed to Jay H. Ryu, M.D., Division of Pulmonary and Critical Care Medicine, Desk East 18, Mayo Clinic, 200 First Street SW, Rochester, MN 55905. E-mail: ryu.jay{at}mayo.edu
Bronchiolar abnormalities are relatively common and occur in a variety of clinical settings. Various histopathologic patterns of bronchiolar injury have been described and have led to confusing nomenclature with redundant and overlapping terms. Some histopathologic patterns of bronchiolar disease may be relatively unique to a specific clinical context but others are nonspecific with respect to either etiology or pathogenesis. Herein, we present a scheme separating (1) those disorders in which the bronchiolar disease is the predominant abnormality (primary bronchiolar disorders) from (2) parenchymal disorders with prominent bronchiolar involvement and (3) bronchiolar involvement in large airway diseases. Primary bronchiolar disorders include constrictive bronchiolitis (obliterative bronchiolitis, bronchiolitis obliterans), acute bronchiolitis, diffuse panbronchiolitis, respiratory bronchiolitis, mineral dust airway disease, follicular bronchiolitis, and a few other rare variants. Prominent bronchiolar involvement may be seen in several interstitial lung diseases, including hypersensitivity pneumonitis, respiratory bronchiolitis–associated interstitial lung disease, cryptogenic organizing pneumonia (idiopathic bronchiolitis obliterans organizing pneumonia), and pulmonary Langerhans' cell histiocytosis. Large airway diseases that commonly involve bronchioles include bronchiectasis, asthma, and chronic obstructive pulmonary disease. The clinical relevance of a bronchiolar lesion is best determined by identifying the underlying histopathologic pattern and assessing the correlative clinico–physiologic–radiologic context.
Key Words: bronchiolitis • bronchiolitis obliterans • organizing pneumonia
This article has been cited by other articles:
|
|
|
|
 
K. Emami, M. Stephen, S. Kadlecek, R. V. Cadman, M. Ishii, and R. R. Rizi
Quantitative Assessment of Lung Using Hyperpolarized Magnetic Resonance Imaging
Proceedings of the ATS,
August 15, 2009;
6(5):
431 - 438.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Uchiyama, R. Suda, S. Yamao, H. Horinouchi, R. Sugiura, Y. Tomishima, T. Jinta, N. Nishimura, and N. Chohnabayashi
Organising pneumonia after near-drowning
BMJ Case Reports,
June 11, 2009;
2008(jun09_1):
bcr0220091557 - bcr0220091557.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
D Hayes Jr and H. Ballard
Saber-sheath trachea in a patient with bronchiolitis obliterans syndrome after lung transplantation
Chronic Respiratory Disease,
February 1, 2009;
6(1):
49 - 52.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G. Pacheco-Rodriguez, F. Kumaki, W. K. Steagall, Y. Zhang, Y. Ikeda, J.-P. Lin, E. M. Billings, and J. Moss
Chemokine-Enhanced Chemotaxis of Lymphangioleiomyomatosis Cells with Mutations in the Tumor Suppressor TSC2 Gene
J. Immunol.,
February 1, 2009;
182(3):
1270 - 1277.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H. Ryu
Unusual and Uncommon Pulmonary Disorders
ACCP Pulmonary Med Brd Rev,
January 1, 2009;
25(0):
479 - 486.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. Lynch III
Rare Interstitial Lung Diseases: Pulmonary Langerhans Cell Histiocytosis, Lymphangioleiomyomatosis, and Cryptogenic Organizing Pneumonia
ACCP Pulmonary Med Brd Rev,
January 1, 2009;
25(0):
585 - 618.
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. L. Finley, D. A. Galbraith, and D. Weill
Comments on Respiratory Toxicity of Diacetyl [Re: Morgan, D. L., Flake, G. P., Kirby, P. J., and Palmer, S. M. (2008). Respiratory toxicity of diacetyl in C57Bl/6 mice. Toxicol. Sci. 103, 169-180.]
Toxicol. Sci.,
October 1, 2008;
105(2):
429 - 432.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Martinez-Gallo, C. Puy, R. Ruiz-Hernandez, J. M. Rodriguez-Arias, M. Bofill, J. F. Nomdedeu, J. C. Cigudosa, J. L. Rodriguez-Sanchez, and O. de la Calle-Martin
Severe and recurrent episodes of bronchiolitis obliterans organising pneumonia associated with indolent CD4+ CD8+ T-cell leukaemia
Eur. Respir. J.,
June 1, 2008;
31(6):
1368 - 1372.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Z. Tzeng, K. O. Leslie, D. Shelton, and A. Chan
Unusual Dyspnea in a Woman With CREST Syndrome
Chest,
January 1, 2008;
133(1):
286 - 290.
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Maldonado, C. E. Daniels, E. A. Hoffman, E. S. Yi, and J. H. Ryu
Focal Organizing Pneumonia on Surgical Lung Biopsy: Causes, Clinicoradiologic Features, and Outcomes
Chest,
November 1, 2007;
132(5):
1579 - 1583.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H. Ryu, C. E. Daniels, T. E. Hartman, and E. S. Yi
Diagnosis of Interstitial Lung Diseases
Mayo Clin. Proc.,
August 1, 2007;
82(8):
976 - 986.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Hanak, J. M. Golbin, and J. H. Ryu
Causes and Presenting Features in 85 Consecutive Patients With Hypersensitivity Pneumonitis
Mayo Clin. Proc.,
July 1, 2007;
82(7):
812 - 816.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. White and L. A. Ruth-Sahd
Bronchiolitis Obliterans Organizing Pneumonia
Crit. Care Nurse,
June 1, 2007;
27(3):
53 - 66.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-C. Aubry, C. F. Thomas Jr, J. R. Jett, S. J. Swensen, and J. L. Myers
Significance of Multiple Carcinoid Tumors and Tumorlets in Surgical Lung Specimens: Analysis of 28 Patients
Chest,
June 1, 2007;
131(6):
1635 - 1643.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Y. Koh, D. E. Jung, J. Y. Koh, J. Y. Kim, Y. Yoo, and C. K. Kim
Bronchoalveolar Cellularity and Interleukin-8 Levels in Measles Bronchiolitis Obliterans
Chest,
May 1, 2007;
131(5):
1454 - 1460.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Jaradat, C. Stapleton, S. L. Tilley, D. Dixon, C. J. Erikson, J. G. McCaskill, H. S. Kang, M. Angers, G. Liao, J. Collins, et al.
Modulatory Role for Retinoid-related Orphan Receptor {alpha} in Allergen-induced Lung Inflammation
Am. J. Respir. Crit. Care Med.,
December 15, 2006;
174(12):
1299 - 1309.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. P. Shah, H. Xu, P. J. Sime, and D. R. Trawick
Severe airflow obstruction and eosinophilic lung disease after Stevens-Johnson syndrome
Eur. Respir. J.,
December 1, 2006;
28(6):
1276 - 1279.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. W. Visscher and J. L. Myers
Bronchiolitis: The Pathologist's Perspective
Proceedings of the ATS,
March 1, 2006;
3(1):
41 - 47.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Raoof, A. Amchentsev, I. Vlahos, A. Goud, and D. P. Naidich
Pictorial Essay: Multinodular Disease: A High-Resolution CT Scan Diagnostic Algorithm
Chest,
March 1, 2006;
129(3):
805 - 815.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. W. Barnes, R. Vassallo, H. D. Tazelaar, T. E. Hartman, and J. H. Ryu
Diffuse Bronchiolar Disease Due to Chronic Occult Aspiration
Mayo Clin. Proc.,
February 1, 2006;
81(2):
172 - 176.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. K. Brown
Chronic Cough Due to Nonbronchiectatic Suppurative Airway Disease (Bronchiolitis): ACCP Evidence-Based Clinical Practice Guidelines
Chest,
January 1, 2006;
129(1_suppl):
132S - 137S.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Fullmer, L. L. Fan, M. K. Dishop, C. Rodgers, and R. Krance
Successful Treatment of Bronchiolitis Obliterans in a Bone Marrow Transplant Patient With Tumor Necrosis Factor-{alpha} Blockade
Pediatrics,
September 1, 2005;
116(3):
767 - 770.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. B. Niewold and J. H. Ryu
59-Year-Old Woman With Progressive Dyspnea on Exertion
Mayo Clin. Proc.,
December 1, 2004;
79(12):
1567 - 1570.
[PDF]
|
|
|
|
|
|
|
T. K. King and B. D. Gelbman
Response to Long-Term Macrolide Therapy in a Patient with Cryptogenic Adult Bronchiolitis
Chest Meeting Abstracts,
October 1, 2004;
126(4):
963S - 963S.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Tobin
Tuberculosis, Lung Infections, Interstitial Lung Disease, Social Issues and Journalology in AJRCCM 2003
Am. J. Respir. Crit. Care Med.,
January 15, 2004;
169(2):
288 - 300.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Tobin
Chronic Obstructive Pulmonary Disease, Pollution, Pulmonary Vascular Disease, Transplantation, Pleural Disease, and Lung Cancer in AJRCCM 2003
Am. J. Respir. Crit. Care Med.,
January 15, 2004;
169(2):
301 - 313.
[Full Text]
[PDF]
|
|
|
Copyright © 2003 American Thoracic Society
|
|
|
