help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Published ahead of print on September 11, 2003, doi:10.1164/rccm.200305-684OC
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Online Supplement
Right arrow All Versions of this Article:
200305-684OCv1
168/10/1199    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by David, G. L.
Right arrow Articles by London, S. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by David, G. L.
Right arrow Articles by London, S. J.
American Journal of Respiratory and Critical Care Medicine Vol 168. pp. 1199-1204, (2003)
© 2003 American Thoracic Society

Nicotinamide Adenine Dinucleotide (Phosphate) Reduced:Quinone Oxidoreductase and Glutathione S-Transferase M1 Polymorphisms and Childhood Asthma

Gloria L. David, Isabelle Romieu, Juan Jose Sienra-Monge, William J. Collins, Matiana Ramirez-Aguilar, Blanca Estela del Rio-Navarro, Norma Isabel Reyes-Ruiz, Richard W. Morris, Jacqueline M. Marzec and Stephanie J. London

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina; National Institute of Public Health, Cuernavaca; and Hospital Infantil de Mexico Frederico Gomez, Mexico City, Mexico

Correspondence and requests for reprints should be addressed to Gloria David, Ph.D., National Institute of Environmental Health Sciences, PO Box 12233, MD D2-01, Research Triangle Park, NC 27709. E-mail: davidbe1{at}niehs.nih.gov

Nicotinamide adenine dinucleotide (phosphate) reduced:quinone oxidoreductase (NQO1) and glutathione S-transferase (GST) M1 are phase II enzymes important in response to oxidative stress, such as occurs during exposure to ozone. We examined the relationship between functionally significant polymorphisms in NQO1 (Pro187Ser) and GSTM1 (homozygous deletion) and asthma risk in children with high lifetime exposure to ozone. We enrolled children with asthma from the allergy referral clinic at a public pediatric hospital in Mexico City, together with their parents. We assayed for the Pro187Ser polymorphism in NQO1 using a polymerase chain reaction–restriction fragment length polymorphism assay and for the presence of GSTM1 by polymerase chain reaction among 218 case–parent triads. We did not find strong evidence of an association between NQO1 genotype alone and asthma risk. However, among subjects with homozygous deletion of GSTM1, carriers of a serine allele were at significantly reduced risk of asthma compared with Pro/Pro homozygotes (relative risk = 0.4; 95% confidence interval, 0.2–0.8). The p value for difference in relative risk for NQO1 by GSTM1 genotype = 0.013. These data are consistent with a protective effect of the NQO1 Ser allele in this population of GSTM1-null children with high ozone exposure.

Key Words: case–parent triad • oxidative stress • environmental tobacco smoke • GSTM1 • NQO1




This article has been cited by other articles:


Home page
 ThoraxHome page
I A Yang, K M Fong, P V Zimmerman, S T Holgate, and J W Holloway
Genetic susceptibility to the respiratory effects of air pollution
Thorax, June 1, 2008; 63(6): 555 - 563.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
I. Romieu, F. Castro-Giner, N. Kunzli, and J. Sunyer
Air pollution, oxidative stress and dietary supplementation: a review
Eur. Respir. J., January 1, 2008; 31(1): 179 - 197.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
S McLeish and S W Turner
Gene environment interactions in asthma
Arch. Dis. Child., November 1, 2007; 92(11): 1032 - 1035.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
C. Chen, M. Arjomandi, I. B. Tager, N. Holland, and J. R. Balmes
Effects of antioxidant enzyme polymorphisms on ozone-induced lung function changes
Eur. Respir. J., October 1, 2007; 30(4): 677 - 683.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
S. J. London
Gene-Air Pollution Interactions in Asthma
Proceedings of the ATS, July 1, 2007; 4(3): 217 - 220.
[Abstract] [Full Text] [PDF]

Home page
 Occup. Environ. Med.Home page
F Castro-Giner, F Kauffmann, R de Cid, and M Kogevinas
Gene-environment interactions in asthma.
Occup. Environ. Med., November 1, 2006; 63(11): 776 - 761.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. M. Hunninghake, S. T. Weiss, and J. C. Celedon
Asthma in Hispanics
Am. J. Respir. Crit. Care Med., January 15, 2006; 173(2): 143 - 163.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. A. Yang, O. Holz, R. A. Jorres, H. Magnussen, S. J. Barton, S. Rodriguez, J. A. Cakebread, J. W. Holloway, and S. T. Holgate
Association of Tumor Necrosis Factor-{alpha} Polymorphisms and Ozone-induced Change in Lung Function
Am. J. Respir. Crit. Care Med., January 15, 2005; 171(2): 171 - 176.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Asthma, Airway Biology, and Nasal Disorders in AJRCCM 2003
Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 265 - 276.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Pediatrics, Surfactant, and Cystic Fibrosis in AJRCCM 2003
Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 277 - 287.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2003 American Thoracic Society