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Quadriceps Fatigability after Single Muscle Exercise in Patients with Chronic Obstructive Pulmonary Disease

Division of Pulmonary, Critical Care, and Sleep Medicine, State University of New York at Buffalo; and the Veterans Affairs Western New York Healthcare System, Buffalo, New York

Correspondence and requests for reprints should be addressed to M. Jeffery Mador, M.D., Division of Pulmonary, Critical Care and Sleep Medicine, Section 111S, State University of New York at Buffalo, Veterans Administration Medical Center, 3495 Bailey Avenue, Buffalo, New York 14215. E-mail: mador{at}acsu.buffalo.edu

The purpose of this study was to compare quadriceps fatigability in patients with varying severity of chronic obstructive pulmonary disease with age-matched control subjects. Ten healthy control subjects, 8 patients with severe disease (FEV₁ less than 35% predicted), and 11 patients with mild to moderate disease were studied. The FEV₁ was 1.75 ± 0.13 L (SE), 50.4 ± 2.9% of predicted in the mild to moderate group, and 0.87 ± 0.06 L, 25.9 ± 1.9% of predicted in the severe group. Quadriceps fatigue was quantified by the reduction in potentiated twitch force after a potentially fatiguing task. All subjects performed three sets of 10 maximum voluntary contractions of the right quadriceps muscle. Quadriceps maximum voluntary contraction force was 58.3 ± 3.3 kg for the healthy older group, 49.0 ± 4.2 kg in the mild to moderate group, and 44.3 ± 4.7 kg in the severe group. The fall in potentiated twitch force after exercise was significantly greater in the patients with severe disease than in the healthy control subjects. In conclusion, the quadriceps in patients with severe chronic obstructive pulmonary disease are more fatigable than those in age- and sex-matched healthy control subjects.

Key Words: lung disease, obstructive • skeletal muscle • muscle fatigue • quadriceps

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