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American Journal of Respiratory and Critical Care Medicine Vol 167. pp. 1142-1149, (2003)
© 2003 American Thoracic Society

NHLBI Workshop Summary

Clinical Research in Chronic Obstructive Pulmonary Disease

Needs and Opportunities

Thomas L. Croxton, Gail G. Weinmann, Robert M. Senior, Robert A. Wise, James D. Crapo and A. Sonia Buist

Division of Lung Diseases, National Heart, Lung, and Blood Institute, Bethesda, Maryland; Departments of Medicine and of Cell Biology and Physiology, Washington University School of Medicine and Barnes-Jewish Hospital, St. Louis, Missouri; Department of Medicine, The Johns Hopkins University, Baltimore, Maryland; Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado; and Department of Medicine, Oregon Health and Science University, Portland, Oregon

Correspondence and requests for reprints should be addressed to Tom Croxton, DLD/NHLBI, Room 10208, 6701 Rockledge Drive, Bethesda, MD 20892-7952. E-mail: croxtont{at}nhlbi.nih.gov

ABSTRACT

Chronic obstructive pulmonary disease (COPD) is a common condition, and one difficult to manage. Available treatments, other than smoking cessation, are only minimally effective, and the knowledge basis for clinical decision making is limited. To identify areas in which further clinical research may lead to significant improvements in the care of patients with COPD, the National Heart, Lung, and Blood Institute convened a Working Group, entitled "Clinical Research in COPD: Needs and Opportunities," on March 21–22, 2002. This group of experts identified important questions in the field and made the following recommendations: (1) establish a multicenter Clinical Research Network to perform multiple, short-term clinical trials of treatments in patients with moderate-to-severe COPD; (2) create a system for the standardized collection, processing, and distribution of lung tissue specimens and associated clinical and laboratory data; (3) develop standards for the classification and staging of COPD; (4) characterize the development and progression of COPD using measures and biomarkers that relate to current concepts of pathogenesis; and (5) evaluate indications for long-term oxygen therapy for patients with COPD.

Key Words: chronic obstructive pulmonary disease • lung diseases, obstructive • National Institutes of Health




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