This Article Full Text Full Text (PDF) All Versions of this Article: 200207-665OCv1 167/12/1704    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Suga, K. Articles by Matsunaga, N. Search for Related Content PubMed PubMed Citation Articles by Suga, K. Articles by Matsunaga, N.

Altered Clearance of Gadolinium Diethylenetriaminepentaacetic Acid Aerosol from Bleomycin-injured Dog Lungs

Initial Observations

Department of Radiology, Yamaguchi University School of Medicine, Ube, Japan

Correspondence and requests for reprints should be addressed to Kazuyoshi Suga, M.D., Department of Radiology, Yamaguchi University School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan. E-mail: sugar{at}po.cc.yamaguchi-u.ac.jp

To characterize altered alveolar transfer to solute in bleomycin (BLM)-injured lungs, eight dogs underwent a gadolinium diethylenetriaminepentaacetic acid aerosol (Gd-AS) magnetic resonance imaging study before and on Days 7 and 40 after tracheal instillation of BLM (0.75 mg) in the left lungs. Consecutive fast-gradient echo magnetic resonance imaging was acquired during and after spontaneous inhalation of 200-mM Gd-AS. The slope (Kep) and clearance half-time (T1/2) of logarithmic regression lines for clearance curves were estimated. Histology on Day 40 was compared with that on Day 7 in another three dogs. On Days 7 and 40, Gd-AS deposition was heterogeneously reduced in the affected lungs. On Day 7 with multifocal intraalveolar exudative changes, Kep in affected areas was significantly increased compared with baseline (2.5 x 10^-3 minutes^-1 ± 0.3 versus 1.7 x 10^-3 minutes^-1 ± 0.2, p < 0.0001), with significant decrease in T1/2 (121.6 ± 19.7 minutes vs. 170.4 ± 15.8 minutes, p < 0.001). However, on Day 40 with multifocal interstitial fibrosis, Kep and T1/2 were recovered toward baseline. BLM-injured lungs can be characterized by accelerated Gd-AS clearance during the acute exudative phase and their recovery during the chronic fibrotic phase. This technique is acceptable for monitoring alveolar transfer changes in BLM-injured lungs.

Key Words: magnetic resonance imaging • aerosol • bleomycin-injured lungs • gadolinium diethylenetriaminepentaacetic acid

This article has been cited by other articles:

				W. E. Lawson, V. V. Polosukhin, O. Zoia, G. T. Stathopoulos, W. Han, D. Plieth, J. E. Loyd, E. G. Neilson, and T. S. Blackwell Characterization of Fibroblast-specific Protein 1 in Pulmonary Fibrosis Am. J. Respir. Crit. Care Med., April 15, 2005; 171(8): 899 - 907. [Abstract] [Full Text] [PDF]

				M. Dolovich and R. Labiris Imaging Drug Delivery and Drug Responses in the Lung Proceedings of the ATS, December 1, 2004; 1(4): 329 - 337. [Abstract] [Full Text] [PDF]

				M. J. Tobin Tuberculosis, Lung Infections, Interstitial Lung Disease, Social Issues and Journalology in AJRCCM 2003 Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 288 - 300. [Full Text] [PDF]