help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Payne, D. N. R.
Right arrow Articles by Jeffery, P. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Payne, D. N. R.
Right arrow Articles by Jeffery, P. K.
American Journal of Respiratory and Critical Care Medicine Vol 167. pp. 78-82, (2003)
© 2003 American Thoracic Society

Original Article

Early Thickening of the Reticular Basement Membrane in Children with Difficult Asthma

Donald N. R. Payne, Andrew V. Rogers, Ellinor Ädelroth, Venkata Bandi, Kalpalatha K. Guntupalli, Andrew Bush and Peter K. Jeffery

Departments of Paediatrics and Lung Pathology, Imperial College at the Royal Brompton Hospital, London, United Kingdom; Department of Pulmonary Medicine, University Hospital, Umeå, Sweden; and Departments of Pulmonary/Critical Care, Baylor College of Medicine, Houston, Texas

Correspondence and requests for reprints should be addressed to Peter K. Jeffery, Department of Lung Pathology, Royal Brompton Hospital, Sydney Street, London, SW3 6NP UK. E-mail: p.jeffery{at}ic.ac.uk

Remodeling of the airway wall occurs in adults with asthma, and reticular basement membrane (RBM) thickening is pathognomonic of the asthma process. To investigate whether RBM thickening is present in children with difficult asthma and comparable to that seen in adults with asthma, we used light microscopy to measure RBM thickness in plastic-embedded endobronchial biopsy sections from 19 children with difficult asthma who were prescribed 1,600 µg/day or more of inhaled steroids (age range, 6–16 years), 10 children without asthma (7–16 years), and three adult groups: 8 healthy control subjects (21–42 years), 10 mild steroid-naive subjects with asthma (18–41 years), and 6 adults (3 steroid naive and 3 on inhaled steroids) intubated after a life-threatening attack of asthma (20–64 years). RBM thickness in the children with asthma was similar to that in adults with either mild or life-threatening asthma (median 8.2 [range 5.4–11.1] versus 8.1 [5.8–10.0] and 7.2 [2.8–10.0] µm, respectively) and greater than either adult or pediatric control subjects (8.2 [5.4–11.1] versus 4.4 [3.2–6.3] µm, p < 0.01, and 4.9 [3.7–8.3] µm, p < 0.01). We conclude that RBM thickening is already present in children with difficult asthma and to a similar extent to that seen in adults with asthma. In addition, we find no association with age, symptom duration, lung function, or concurrent eosinophilic airway inflammation.

Key Words: airway remodeling • endobronchial biopsy • pediatrics




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
T.-L. Hackett, S. M. Warner, D. Stefanowicz, F. Shaheen, D. V. Pechkovsky, L. A. Murray, R. Argentieri, A. Kicic, S. M. Stick, T. R. Bai, et al.
Induction of Epithelial-Mesenchymal Transition in Primary Airway Epithelial Cells from Patients with Asthma by Transforming Growth Factor-{beta}1
Am. J. Respir. Crit. Care Med., July 15, 2009; 180(2): 122 - 133.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
C. Bergeron, W. Al-Ramli, and Q. Hamid
Remodeling in Asthma
Proceedings of the ATS, May 1, 2009; 6(3): 301 - 305.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
Paediatric lung disease
Thorax, December 1, 2008; 63(Suppl_7): A32 - A35.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C.-H. Wang, C.-D. Huang, H.-C. Lin, K.-Y. Lee, S.-M. Lin, C.-Y. Liu, K.-H. Huang, Y.-S. Ko, K. F. Chung, and H.-P. Kuo
Increased Circulating Fibrocytes in Asthma with Chronic Airflow Obstruction
Am. J. Respir. Crit. Care Med., September 15, 2008; 178(6): 583 - 591.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
H. Meurs, R. Gosens, and J. Zaagsma
Airway hyperresponsiveness in asthma: lessons from in vitro model systems and animal models
Eur. Respir. J., August 1, 2008; 32(2): 487 - 502.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. Regamey, M. Ochs, T. N. Hilliard, C. Muhlfeld, N. Cornish, L. Fleming, S. Saglani, E. W. F. W. Alton, A. Bush, P. K. Jeffery, et al.
Increased Airway Smooth Muscle Mass in Children with Asthma, Cystic Fibrosis, and Non-Cystic Fibrosis Bronchiectasis
Am. J. Respir. Crit. Care Med., April 15, 2008; 177(8): 837 - 843.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bush
Update in Pediatric Lung Disease 2007
Am. J. Respir. Crit. Care Med., April 1, 2008; 177(7): 686 - 695.
[Full Text] [PDF]

Home page
 ThoraxHome page
T. N Hilliard, N. Regamey, J. K Shute, A. G Nicholson, E. W F W Alton, A. Bush, and J. C Davies
Airway remodelling in children with cystic fibrosis
Thorax, December 1, 2007; 62(12): 1074 - 1080.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Saglani, D. N. Payne, J. Zhu, Z. Wang, A. G. Nicholson, A. Bush, and P. K. Jeffery
Early Detection of Airway Wall Remodeling and Eosinophilic Inflammation in Preschool Wheezers
Am. J. Respir. Crit. Care Med., November 1, 2007; 176(9): 858 - 864.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Nuijsink, W. C. J. Hop, P. J. Sterk, E. J. Duiverman, J. C. de Jongste, and on behalf of the Children Asthma Therapy Optimal (
Long-term asthma treatment guided by airway hyperresponsiveness in children: a randomised controlled trial
Eur. Respir. J., September 1, 2007; 30(3): 457 - 466.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. Cohen, X. E, J. Tarsi, T. Ramkumar, T. K. Horiuchi, R. Cochran, S. DeMartino, K. B. Schechtman, I. Hussain, M. J. Holtzman, et al.
Epithelial Cell Proliferation Contributes to Airway Remodeling in Severe Asthma
Am. J. Respir. Crit. Care Med., July 15, 2007; 176(2): 138 - 145.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. L. James and S. Wenzel
Clinical relevance of airway remodelling in airway diseases
Eur. Respir. J., July 1, 2007; 30(1): 134 - 155.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
N. Regamey, T. N. Hilliard, S. Saglani, J. Zhu, M. Scallan, I. M. Balfour-Lynn, M. Rosenthal, P. K. Jeffery, E. W. F. W. Alton, A. Bush, et al.
Quality, Size, and Composition of Pediatric Endobronchial Biopsies in Cystic Fibrosis
Chest, June 1, 2007; 131(6): 1710 - 1717.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
C. M. Lloyd and D. S. Robinson
Allergen-induced airway remodelling
Eur. Respir. J., May 1, 2007; 29(5): 1020 - 1032.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S. T. Holgate, D. E. Davies, R. M. Powell, P. H. Howarth, H. M. Haitchi, and J. W. Holloway
Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms
Eur. Respir. J., April 1, 2007; 29(4): 793 - 803.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
A. Torrego, M. Hew, T. Oates, M. Sukkar, and K. Fan Chung
Expression and activation of TGF-{beta} isoforms in acute allergen-induced remodelling in asthma
Thorax, April 1, 2007; 62(4): 307 - 313.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
N. Henderson, L. J. Markwick, S. R. Elshaw, A. M. Freyer, A. J. Knox, and S. R. Johnson
Collagen I and thrombin activate MMP-2 by MMP-14-dependent and -independent pathways: implications for airway smooth muscle migration
Am J Physiol Lung Cell Mol Physiol, April 1, 2007; 292(4): L1030 - L1038.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bush
Update in Pediatric Lung Disease 2006
Am. J. Respir. Crit. Care Med., March 15, 2007; 175(6): 532 - 540.
[Full Text] [PDF]

Home page
 Toxicol PatholHome page
C. G. Plopper, S. M. Smiley-Jewell, L. A. Miller, M. V. Fanucchi, M. J. Evans, A. R. Buckpitt, M. Avdalovic, L. J. Gershwin, J. P. Joad, R. Kajekar, et al.
Asthma/Allergic Airways Disease: Does Postnatal Exposure to Environmental Toxicants Promote Airway Pathobiology?
Toxicol Pathol, January 1, 2007; 35(1): 97 - 110.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bush and I. Annesi-Maesano
"Beam Me Up, Scotty!"
Am. J. Respir. Crit. Care Med., January 1, 2007; 175(1): 1 - 2.
[Full Text] [PDF]

Home page
 ChestHome page
A. Shibata, T. Katsunuma, M. Tomikawa, A. Tan, K. Yuki, K. Akashi, and Y. Eto
Increased Leukotriene E4 in the Exhaled Breath Condensate of Children With Mild Asthma
Chest, December 1, 2006; 130(6): 1718 - 1722.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. F. Chung
Intrinsic differences of the airway epithelium in childhood allergic asthma.
Am. J. Respir. Crit. Care Med., November 15, 2006; 174(10): 1066 - 1067.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Barbato, G. Turato, S. Baraldo, E. Bazzan, F. Calabrese, C. Panizzolo, M. E. Zanin, R. Zuin, P. Maestrelli, L. M. Fabbri, et al.
Epithelial Damage and Angiogenesis in the Airways of Children with Asthma
Am. J. Respir. Crit. Care Med., November 1, 2006; 174(9): 975 - 981.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S. Saglani, C. Molyneux, H. Gong, A. Rogers, K. Malmstrom, A. Pelkonen, M. Makela, E. Adelroth, A. Bush, D. N. R. Payne, et al.
Ultrastructure of the reticular basement membrane in asthmatic adults, children and infants
Eur. Respir. J., September 1, 2006; 28(3): 505 - 512.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. Bergeron and L.-P. Boulet
Structural changes in airway diseases: characteristics, mechanisms, consequences, and pharmacologic modulation.
Chest, April 1, 2006; 129(4): 1068 - 1087.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
W. R. Henderson Jr., G. K. S. Chiang, Y.-t. Tien, and E. Y. Chi
Reversal of Allergen-induced Airway Remodeling by CysLT1 Receptor Blockade
Am. J. Respir. Crit. Care Med., April 1, 2006; 173(7): 718 - 728.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bush
Update in pediatrics 2005.
Am. J. Respir. Crit. Care Med., March 15, 2006; 173(6): 585 - 592.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
C. Boxall, S. T. Holgate, and D. E. Davies
The contribution of transforming growth factor-{beta} and epidermal growth factor signalling to airway remodelling in chronic asthma
Eur. Respir. J., January 1, 2006; 27(1): 208 - 229.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. S. Braman
Chronic Cough Due to Chronic Bronchitis: ACCP Evidence-Based Clinical Practice Guidelines
Chest, January 1, 2006; 129(1_suppl): 104S - 115S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Simpson, N. Maniatis, F. Jury, J. A. Cakebread, L. A. Lowe, S. T. Holgate, A. Woodcock, W. E. R. Ollier, A. Collins, A. Custovic, et al.
Polymorphisms in A Disintegrin and Metalloprotease 33 (ADAM33) Predict Impaired Early-Life Lung Function
Am. J. Respir. Crit. Care Med., July 1, 2005; 172(1): 55 - 60.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. Melen, S. Bruce, G. Doekes, M. Kabesch, T. Laitinen, R. Lauener, C. M. Lindgren, J. Riedler, A. Scheynius, M. van Hage-Hamsten, et al.
Haplotypes of G Protein-coupled Receptor 154 Are Associated with Childhood Allergy and Asthma
Am. J. Respir. Crit. Care Med., May 15, 2005; 171(10): 1089 - 1095.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
I A Fedorov, S J Wilson, D E Davies, and S T Holgate
Epithelial stress and structural remodelling in childhood asthma
Thorax, May 1, 2005; 60(5): 389 - 394.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. M. Haitchi, R. M. Powell, T. J. Shaw, P. H. Howarth, S. J. Wilson, D. I. Wilson, S. T. Holgate, and D. E. Davies
ADAM33 Expression in Asthmatic Airways and Human Embryonic Lungs
Am. J. Respir. Crit. Care Med., May 1, 2005; 171(9): 958 - 965.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. J. Szefler
Airway Remodeling: Therapeutic Target or Not?
Am. J. Respir. Crit. Care Med., April 1, 2005; 171(7): 672 - 673.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Saglani, K. Malmstrom, A. S. Pelkonen, L. P. Malmberg, H. Lindahl, M. Kajosaari, M. Turpeinen, A. V. Rogers, D. N. Payne, A. Bush, et al.
Airway Remodeling and Inflammation in Symptomatic Infants with Reversible Airflow Obstruction
Am. J. Respir. Crit. Care Med., April 1, 2005; 171(7): 722 - 727.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. M. Teper, C. D. Kofman, G. A. Szulman, S. M. Vidaurreta, and A. F. Maffey
Fluticasone Improves Pulmonary Function in Children under 2 Years Old with Risk Factors for Asthma
Am. J. Respir. Crit. Care Med., March 15, 2005; 171(6): 587 - 590.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
R. J. Homer and J. A. Elias
Airway Remodeling in Asthma: Therapeutic Implications of Mechanisms
Physiology, February 1, 2005; 20(1): 28 - 35.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. Phipps, F. Benyahia, T.-T. Ou, J. Barkans, D. S. Robinson, and A. B. Kay
Acute Allergen-Induced Airway Remodeling in Atopic Asthma
Am. J. Respir. Cell Mol. Biol., December 1, 2004; 31(6): 626 - 632.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
P. K. Jeffery
Remodeling and Inflammation of Bronchi in Asthma and Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, November 1, 2004; 1(3): 176 - 183.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. F. Gelb, A. Schein, E. Nussbaum, C. M. Shinar, Y. Aelony, H. Aharonian, and N. Zamel
Risk Factors for Near-Fatal Asthma
Chest, October 1, 2004; 126(4): 1138 - 1146.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
D N R Payne, Y Qiu, J Zhu, L Peachey, M Scallan, A Bush, and P K Jeffery
Airway inflammation in children with difficult asthma: relationships with airflow limitation and persistent symptoms
Thorax, October 1, 2004; 59(10): 862 - 869.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. F. Gelb, C. F. Taylor, E. Nussbaum, C. Gutierrez, A. Schein, C. M. Shinar, M. J. Schein, J. D. Epstein, and N. Zamel
Alveolar and Airway Sites of Nitric Oxide Inflammation in Treated Asthma
Am. J. Respir. Crit. Care Med., October 1, 2004; 170(7): 737 - 741.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. A. Covar, J. D. Spahn, J. R. Murphy, and S. J. Szefler
Progression of Asthma Measured by Lung Function in the Childhood Asthma Management Program
Am. J. Respir. Crit. Care Med., August 1, 2004; 170(3): 234 - 241.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P.J.F.M. Merkus, W. van Pelt, J.C. van Houwelingen, L.E.M. van Essen-Zandvliet, E.J. Duiverman, K.F. Kerrebijn, and P.H. Quanjer
Inhaled corticosteroids and growth of airway function in asthmatic children
Eur. Respir. J., June 1, 2004; 23(6): 861 - 868.
[Abstract] [Full Text] [PDF]

Home page
 QJMHome page
S.T. Holgate
Lessons learnt from the epidemic of asthma
QJM, May 1, 2004; 97(5): 247 - 257.
[Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
S. T. Holgate, J. Holloway, S. Wilson, F. Bucchieri, S. Puddicombe, and D. E. Davies
Epithelial-Mesenchymal Communication in the Pathogenesis of Chronic Asthma
Proceedings of the ATS, April 1, 2004; 1(2): 93 - 98.
[Abstract] [Full Text] [PDF]

Home page
 JRSMHome page
S. T Holgate
The epidemic of asthma and allergy
J R Soc Med, March 1, 2004; 97(3): 103 - 110.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Asthma, Airway Biology, and Nasal Disorders in AJRCCM 2003
Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 265 - 276.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Pediatrics, Surfactant, and Cystic Fibrosis in AJRCCM 2003
Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 277 - 287.
[Full Text] [PDF]

Home page
 ThoraxHome page
S Saglani, D N R Payne, A G Nicholson, M Scallan, E Haxby, and A Bush
The safety and quality of endobronchial biopsy in children under five years old
Thorax, December 1, 2003; 58(12): 1053 - 1057.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
P S Salva, C Theroux, and D Schwartz
Safety of endobronchial biopsy in 170 children with chronic respiratory symptoms
Thorax, December 1, 2003; 58(12): 1058 - 1060.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
F. Midulla, J. de Blic, A. Barbato, A. Bush, E Eber, S Kotecha, E Haxby, C Moretti, P Pohunek, and F Ratjen
Flexible endoscopy of paediatric airways
Eur. Respir. J., October 1, 2003; 22(4): 698 - 708.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Barbato, G. Turato, S. Baraldo, E. Bazzan, F. Calabrese, M. Tura, R. Zuin, B. Beghe, P. Maestrelli, L. M. Fabbri, et al.
Airway Inflammation in Childhood Asthma
Am. J. Respir. Crit. Care Med., October 1, 2003; 168(7): 798 - 803.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. O. Warner
The Blood Lung Function Test: Does It Exist for Asthma?
Am. J. Respir. Crit. Care Med., June 1, 2003; 167(11): 1465 - 1466.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2003 American Thoracic Society 		  Red Transition