help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Päth, G.
Right arrow Articles by Renz, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Päth, G.
Right arrow Articles by Renz, H.
American Journal of Respiratory and Critical Care Medicine Vol 166. pp. 818-826, (2002)
© 2002 American Thoracic Society

Original Articles

Augmentation of Allergic Early-Phase Reaction by Nerve Growth Factor

Günter Päth, Armin Braun, Nina Meents, Sebastian Kerzel, David Quarcoo, Ulrike Raap, Gary W. Hoyle, Wolfgang A. Nockher and Harald Renz

Department of Clinical Chemistry and Molecular Diagnostic, University Hospital of Marburg, Marburg; Fraunhofer Institute of Toxicology and Aerosol Research, Hannover; Charité-Campus Virchow, Berlin, Germany; and Section of Pulmonary Disease, Critical Care and Environmental Medicine, Department of Medicine, Tulane University Medical Center, New Orleans, Louisiana

Correspondence and requests for reprints should be addressed to Harald Renz, M.D., University Hospital of Marburg, Department of Clinical Chemistry and Molecular Diagnostic, Baldingerstrasse, 35033 Marburg, Germany. E-mail: renzh{at}post.med.uni-marburg.de

The allergic early-phase reaction, a hallmark of allergic bronchial asthma, is caused by allergen and immunoglobulin E-dependent mediator release from mast cells. It was previously shown that nerve growth factor (NGF) contributes to acute airway inflammation. This study further investigates the role of NGF in the allergic early-phase reaction using a well-established mouse model of ovalbumin-induced allergic airway inflammation. Treatment of sensitized and aerosol challenged BALB/c mice with blocking anti-NGF antibodies inhibited allergen-induced early-phase reaction and suppressed airway inflammation. Transgenic mice constitutively overexpressing NGF in the airways (Clara-cell secretory protein promoter [CCSP]-NGF-tg) were employed and compared with wild-type animals. In sensitized and challenged CCSP-NGF-tg mice, early-phase reaction, airway inflammation, as well as percental relative increases in serotonin levels were augmented compared with wild-type mice. These effects were paralleled by increased serotonin levels in the airways, whereas immunoglobulin E levels remained unaffected. Furthermore, CCSP-NGF-tg mice developed an increased reactivity of sensory neurons in response to inhaled capsaicin demonstrating NGF-mediated neuronal plasticity. These data provide evidence for the functional role of NGF in the development of allergic early phase responses in the airways and the lung.

Key Words: nerve growth factor • allergy type I • airway inflammation • neurogenic inflammation • bronchial asthma • mouse model




This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
N. G. Verbout, D. B. Jacoby, G. J. Gleich, and A. D. Fryer
Atropine-enhanced, antigen challenge-induced airway hyperreactivity in guinea pigs is mediated by eosinophils and nerve growth factor
Am J Physiol Lung Cell Mol Physiol, August 1, 2009; 297(2): L228 - L237.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Abram, M. Wegmann, V. Fokuhl, S. Sonar, E. O. Luger, S. Kerzel, A. Radbruch, H. Renz, and M. Zemlin
Nerve Growth Factor and Neurotrophin-3 Mediate Survival of Pulmonary Plasma Cells during the Allergic Airway Inflammation
J. Immunol., April 15, 2009; 182(8): 4705 - 4712.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
M. Henjakovic, C. Martin, H. G. Hoymann, K. Sewald, A. R. Ressmeyer, C. Dassow, G. Pohlmann, N. Krug, S. Uhlig, and A. Braun
Ex Vivo Lung Function Measurements in Precision-Cut Lung Slices (PCLS) from Chemical Allergen-Sensitized Mice Represent a Suitable Alternative to In Vivo Studies
Toxicol. Sci., December 1, 2008; 106(2): 444 - 453.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
T. Z. Veres, S. Rochlitzer, M. Shevchenko, B. Fuchs, F. Prenzler, C. Nassenstein, A. Fischer, L. Welker, O. Holz, M. Muller, et al.
Spatial Interactions between Dendritic Cells and Sensory Nerves in Allergic Airway Inflammation
Am. J. Respir. Cell Mol. Biol., November 1, 2007; 37(5): 553 - 561.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. M. Trujillo-Vargas, M. Werner-Klein, G. Wohlleben, T. Polte, G. Hansen, S. Ehlers, and K. J. Erb
Helminth-derived Products Inhibit the Development of Allergic Responses in Mice
Am. J. Respir. Crit. Care Med., February 15, 2007; 175(4): 336 - 344.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
A. K. Farraj, N. Haykal-Coates, A. D. Ledbetter, P. A. Evansky, and S. H. Gavett
Neurotrophin Mediation of Allergic Airways Responses to Inhaled Diesel Particles in Mice
Toxicol. Sci., November 1, 2006; 94(1): 183 - 192.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
N. Frossard, E. Naline, C. Olgart Hoglund, O. Georges, and C. Advenier
Nerve growth factor is released by IL-1{beta} and induces hyperresponsiveness of the human isolated bronchus
Eur. Respir. J., July 1, 2005; 26(1): 15 - 20.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Lommatzsch, K. Schloetcke, J. Klotz, K. Schuhbaeck, D. Zingler, C. Zingler, O. Schulte-Herbruggen, H. Gill, P. Schuff-Werner, and J. C. Virchow
Brain-derived Neurotrophic Factor in Platelets and Airflow Limitation in Asthma
Am. J. Respir. Crit. Care Med., January 15, 2005; 171(2): 115 - 120.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
V. Coppola, C. A. Barrick, E. A. Southon, A. Celeste, K. Wang, B. Chen, E.-B. Haddad, J. Yin, A. Nussenzweig, A. Subramaniam, et al.
Ablation of TrkA function in the immune system causes B cell abnormalities
Development, October 15, 2004; 131(20): 5185 - 5195.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
E. R. Wilfong and R. D. Dey
Nerve Growth Factor and Substance P Regulation in Nasal Sensory Neurons after Toluene Diisocyanate Exposure
Am. J. Respir. Cell Mol. Biol., June 1, 2004; 30(6): 793 - 800.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. D. N. Cher, A. Armugam, R. Lachumanan, M.-W. Coghlan, and K. Jeyaseelan
Pulmonary Inflammation and Edema Induced by Phospholipase A2: GLOBAL GENE ANALYSIS AND EFFECTS ON AQUAPORINS AND Na+/K+-ATPase
J. Biol. Chem., August 15, 2003; 278(33): 31352 - 31360.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. Kerzel, G. Path, W. A. Nockher, D. Quarcoo, U. Raap, D. A. Groneberg, Q. T. Dinh, A. Fischer, A. Braun, and H. Renz
Pan-Neurotrophin Receptor p75 Contributes to Neuronal Hyperreactivity and Airway Inflammation in a Murine Model of Experimental Asthma
Am. J. Respir. Cell Mol. Biol., February 1, 2003; 28(2): 170 - 178.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Asthma, Airway Biology, and Nasal Disorders in AJRCCM 2002
Am. J. Respir. Crit. Care Med., February 1, 2003; 167(3): 319 - 332.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2002 American Thoracic Society 		  CCM abstracts