American Journal of Respiratory and Critical Care Medicine Vol 166. pp. 457-463, (2002)
© 2002 American Thoracic Society
Effects of Glutathione S-Transferase M1, Maternal Smoking during Pregnancy, and Environmental Tobacco Smoke on Asthma and Wheezing in Children
Frank D. Gilliland,
Yu-Fen Li,
Louis Dubeau,
Kiros Berhane,
Edward Avol,
Rob McConnell,
W. James Gauderman and
John M. Peters
University of Southern California Keck School of Medicine, Department of Preventive Medicine, Los Angeles, California
Correspondence and requests for reprints should be addressed to Frank Gilliland, M.D., Ph.D., Department of Preventive Medicine, USC Keck School of Medicine, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033. E-mail: gillilan{at}hsc.usc.edu
The rise in childhood asthma prevalence suggests a role for environmental factors in the etiology of this evolving epidemic; however, genetics also influence the occurrence of asthma. Glutathione S-transferase (GST) M1 may play a role in asthma and wheezing occurrence among those exposed to tobacco smoke, as it functions in pathways involved in asthma pathogenesis such as xenobiotic metabolism and antioxidant defenses. Effects of GSTM1 genotype, maternal smoking during pregnancy, and childhood environmental tobacco smoke (ETS) exposure on asthma and wheezing were investigated in 2,950 children enrolled in 4th, 7th, and 10th grade classrooms in 12 Southern California communities. The effects of in utero exposure to maternal smoking on asthma and wheezing occurrence were largely restricted to children with GSTM1 null genotype. Among GSTM1 null children, in utero exposure was associated with increased prevalence of early onset asthma (odds ratio [OR] 1.6, 95% confidence interval [CI] 1.02.5), asthma with current symptoms (OR 1.7, 95% CI 1.12.8), persistent asthma (OR 1.6, 95% CI 1.12.4), lifetime history of wheezing (OR 1.8, 95% CI 1.32.5), wheezing with exercise (OR 2.1, 95% CI 1.33.3), wheezing requiring medication (OR 2.2, 95% CI 1.43.4), and emergency room visits in the past year (OR 3.7, 95% CI 1.97.3). Among children with GSTM1 (+) genotype, in utero exposure was not associated with asthma or wheezing. Our findings indicate that there are important long-term effects of in utero exposure in a genetically susceptible group of children.
Key Words: In utero exposure tobacco smoke GSTM1 asthma wheeze children
This article has been cited by other articles:

|
 |

|
 |
 
A. Bush
Update in Pediatric Lung Disease 2007
Am. J. Respir. Crit. Care Med.,
April 1, 2008;
177(7):
686 - 695.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. L. Miller and S.-m. Ho
Environmental Epigenetics and Asthma: Current Concepts and Call for Studies
Am. J. Respir. Crit. Care Med.,
March 15, 2008;
177(6):
567 - 573.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Islam, R. McConnell, W. J. Gauderman, E. Avol, J. M. Peters, and F. D. Gilliland
Ozone, Oxidant Defense Genes, and Risk of Asthma during Adolescence
Am. J. Respir. Crit. Care Med.,
February 15, 2008;
177(4):
388 - 395.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
I. Romieu, F. Castro-Giner, N. Kunzli, and J. Sunyer
Air pollution, oxidative stress and dietary supplementation: a review
Eur. Respir. J.,
January 1, 2008;
31(1):
179 - 197.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. T Salam, P.-C. Lin, E. L Avol, W J. Gauderman, and F. D Gilliland
Microsomal epoxide hydrolase, glutathione S-transferase P1, traffic and childhood asthma
Thorax,
December 1, 2007;
62(12):
1050 - 1057.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S McLeish and S W Turner
Gene environment interactions in asthma
Arch. Dis. Child.,
November 1, 2007;
92(11):
1032 - 1035.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. Chen, M. Arjomandi, I. B. Tager, N. Holland, and J. R. Balmes
Effects of antioxidant enzyme polymorphisms on ozone-induced lung function changes
Eur. Respir. J.,
October 1, 2007;
30(4):
677 - 683.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y. Koike, T. Hisada, M. Utsugi, T. Ishizuka, Y. Shimizu, A. Ono, Y. Murata, J. Hamuro, M. Mori, and K. Dobashi
Glutathione Redox Regulates Airway Hyperresponsiveness and Airway Inflammation in Mice
Am. J. Respir. Cell Mol. Biol.,
September 1, 2007;
37(3):
322 - 329.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. J. London
Gene-Air Pollution Interactions in Asthma
Proceedings of the ATS,
July 1, 2007;
4(3):
217 - 220.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. N. Hylkema, P. J. Sterk, W. I. de Boer, and D. S. Postma
Tobacco use in relation to COPD and asthma
Eur. Respir. J.,
March 1, 2007;
29(3):
438 - 445.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Bush and I. Annesi-Maesano
"Beam Me Up, Scotty!"
Am. J. Respir. Crit. Care Med.,
January 1, 2007;
175(1):
1 - 2.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
F. D. Gilliland, Y.-F. Li, H. Gong Jr., and D. Diaz-Sanchez
Glutathione S-Transferases M1 and P1 Prevent Aggravation of Allergic Responses by Secondhand Smoke
Am. J. Respir. Crit. Care Med.,
December 15, 2006;
174(12):
1335 - 1341.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
F. D. Gilliland, T. Islam, K. Berhane, W. J. Gauderman, R. McConnell, E. Avol, and J. M. Peters
Regular Smoking and Asthma Incidence in Adolescents
Am. J. Respir. Crit. Care Med.,
November 15, 2006;
174(10):
1094 - 1100.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
F Castro-Giner, F Kauffmann, R de Cid, and M Kogevinas
Gene-environment interactions in asthma.
Occup. Environ. Med.,
November 1, 2006;
63(11):
776 - 761.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
I. Romieu, M. Ramirez-Aguilar, J. J. Sienra-Monge, H. Moreno-Macias, B. E. del Rio-Navarro, G. David, J. Marzec, M. Hernandez-Avila, and S. London
GSTM1 and GSTP1 and respiratory health in asthmatic children exposed to ozone
Eur. Respir. J.,
November 1, 2006;
28(5):
953 - 959.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
F. PERERA, S. VISWANATHAN, R. WHYATT, D. TANG, R. L MILLER, and V. RAUH
Children's Environmental Health Research--Highlights from the Columbia Center for Children's Environmental Health.
Ann. N.Y. Acad. Sci.,
September 1, 2006;
1076:
15 - 28.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Kabesch
A Glitch in the Switch?: Of Endotoxin, CD14, and Allergy.
Am. J. Respir. Crit. Care Med.,
August 15, 2006;
174(4):
365 - 366.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. N.A. Palmer, A. S.F. Doney, S. P. Lee, I. Murrie, T. Ismail, D. F. Macgregor, and S. Mukhopadhyay
Glutathione S-Transferase M1 and P1 Genotype, Passive Smoking, and Peak Expiratory Flow in Asthma
Pediatrics,
August 1, 2006;
118(2):
710 - 716.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. Moshammer, G. Hoek, H. Luttmann-Gibson, M. A. Neuberger, T. Antova, U. Gehring, F. Hruba, S. Pattenden, P. Rudnai, H. Slachtova, et al.
Parental Smoking and Lung Function in Children: An International Study
Am. J. Respir. Crit. Care Med.,
June 1, 2006;
173(11):
1255 - 1263.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y.-F. Li, W. J. Gauderman, E. Avol, L. Dubeau, and F. D. Gilliland
Associations of Tumor Necrosis Factor G-308A with Childhood Asthma and Wheezing
Am. J. Respir. Crit. Care Med.,
May 1, 2006;
173(9):
970 - 976.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Roosli and N. Kunzli
Commentary: Magnetic field exposure and childhood leukaemia--moving the research agenda forward
Int. J. Epidemiol.,
April 1, 2006;
35(2):
407 - 408.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Bush
Update in pediatrics 2005.
Am. J. Respir. Crit. Care Med.,
March 15, 2006;
173(6):
585 - 592.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R J Delfino
Think globally, breathe locally.
Thorax,
March 1, 2006;
61(3):
184 - 185.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y.-L. Lee, T.-R. Hsiue, Y.-C. Lee, Y.-C. Lin, and Y. L. Guo
The Association Between Glutathione S-Transferase P1, M1 Polymorphisms and Asthma in Taiwanese Schoolchildren
Chest,
September 1, 2005;
128(3):
1156 - 1162.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Choudhry, P. C. Avila, S. Nazario, N. Ung, J. Kho, J. R. Rodriguez-Santana, J. Casal, H.-J. Tsai, A. Torres, E. Ziv, et al.
CD14 Tobacco Gene-Environment Interaction Modifies Asthma Severity and Immunoglobulin E Levels in Latinos with Asthma
Am. J. Respir. Crit. Care Med.,
July 15, 2005;
172(2):
173 - 182.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A Greenough, E Limb, L Marston, N Marlow, S Calvert, and J Peacock
Risk factors for respiratory morbidity in infancy after very premature birth
Arch. Dis. Child. Fetal Neonatal Ed.,
July 1, 2005;
90(4):
F320 - f323.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
B P Lanphear and C F Bearer
Biomarkers in paediatric research and practice
Arch. Dis. Child.,
June 1, 2005;
90(6):
594 - 600.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y.-F. Li, B. Langholz, M. T. Salam, and F. D. Gilliland
Maternal and Grandmaternal Smoking Patterns Are Associated With Early Childhood Asthma
Chest,
April 1, 2005;
127(4):
1232 - 1241.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. P. Bradley, L. B. Bacharier, J. Bonfiglio, K. B. Schechtman, R. Strunk, G. Storch, and M. Castro
Severity of Respiratory Syncytial Virus Bronchiolitis Is Affected by Cigarette Smoke Exposure and Atopy
Pediatrics,
January 1, 2005;
115(1):
e7 - e14.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
F. Kauffmann and the Post Genome Respiratory Epidemiology group
Post-genome respiratory epidemiology: a multidisciplinary challenge
Eur. Respir. J.,
September 1, 2004;
24(3):
471 - 480.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M Kabesch, C Hoefler, D Carr, W Leupold, S K Weiland, and E von Mutius
Glutathione S transferase deficiency and passive smoking increase childhood asthma
Thorax,
July 1, 2004;
59(7):
569 - 573.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. G. Barr, C. C. Wentowski, G. C. Curhan, S. C. Somers, M. J. Stampfer, J. Schwartz, F. E. Speizer, and C. A. Camargo Jr.
Prospective Study of Acetaminophen Use and Newly Diagnosed Asthma among Women
Am. J. Respir. Crit. Care Med.,
April 1, 2004;
169(7):
836 - 841.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R Hubbard and A Fogarty
The developing story of antioxidants and asthma
Thorax,
January 1, 2004;
59(1):
3 - 4.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. L. David, I. Romieu, J. J. Sienra-Monge, W. J. Collins, M. Ramirez-Aguilar, B. E. del Rio-Navarro, N. I. Reyes-Ruiz, R. W. Morris, J. M. Marzec, and S. J. London
Nicotinamide Adenine Dinucleotide (Phosphate) Reduced:Quinone Oxidoreductase and Glutathione S-Transferase M1 Polymorphisms and Childhood Asthma
Am. J. Respir. Crit. Care Med.,
November 15, 2003;
168(10):
1199 - 1204.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. Kunzli, R. McConnell, D. Bates, T. Bastain, A. Hricko, F. Lurmann, E. Avol, F. Gilliland, and J. Peters
Breathless in Los Angeles: The Exhausting Search for Clean Air
Am J Public Health,
September 1, 2003;
93(9):
1494 - 1499.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. J. Tobin
Asthma, Airway Biology, and Nasal Disorders in AJRCCM 2002
Am. J. Respir. Crit. Care Med.,
February 1, 2003;
167(3):
319 - 332.
[Full Text]
[PDF]
|
 |
|
Copyright © 2002 American Thoracic Society
|
|
|