This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bowler, R. P. Articles by Crapo, J. D. Search for Related Content PubMed PubMed Citation Articles by Bowler, R. P. Articles by Crapo, J. D.

Oxidative Stress in Airways

Is There a Role for Extracellular Superoxide Dismutase?

National Jewish Medical and Research Center; and Department of Cell and Structural Biology, University of Colorado Health Sciences Center, Denver, Colorado

Correspondence and requests for reprints should be addressed to Russell P. Bowler, M.D., Ph.D., National Jewish Medical and Research Center, K707, 1400 Jackson Street, Denver, CO 80206. E-mail: bowlerr{at}njc.org

ABSTRACT

Airways are exposed to high levels of environmental oxidants, yet they also have enriched extracellular antioxidants. Airways disease such as asthma, cystic fibrosis, and chronic obstructive pulmonary disease have evidence of increased oxidative stress, suggesting that reactive oxygen and nitrogen species may overwhelm antioxidant defenses in airway diseases. Extracellular superoxide dismutase is abundant in pulmonary tissues and protects the lung from increased oxidative stress; however, its role in asthma and other airway diseases has not been fully elucidated. Proteolytic processing of extracellular superoxide dismutase decreases its affinity for the extracellular matrix and may be a mechanism to regulate its distribution during conditions of inflammation or oxidative stress.

Key Words: lung • antioxidant • oxidative stress

This article has been cited by other articles:

				K. Juul, A. Tybjaerg-Hansen, S. Marklund, P. Lange, and B. G. Nordestgaard Genetically Increased Antioxidative Protection and Decreased Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., April 15, 2006; 173(8): 858 - 864. [Abstract] [Full Text] [PDF]

				N. Dauletbaev, J. Rickmann, K. Viel, H. Diegel, C. von Mallinckrodt, J. Stein, T. O. F. Wagner, and J. Bargon Antioxidant properties of cystic fibrosis sputum Am J Physiol Lung Cell Mol Physiol, May 1, 2005; 288(5): L903 - L909. [Abstract] [Full Text] [PDF]

				C. Schwarzer, T. E. Machen, B. Illek, and H. Fischer NADPH Oxidase-dependent Acid Production in Airway Epithelial Cells J. Biol. Chem., August 27, 2004; 279(35): 36454 - 36461. [Abstract] [Full Text] [PDF]

				D. Strassheim, K. Asehnoune, J.-S. Park, J.-Y. Kim, Q. He, D. Richter, S. Mitra, J. Arcaroli, K. Kuhn, and E. Abraham Modulation of bone marrow-derived neutrophil signaling by H2O2: disparate effects on kinases, NF-{kappa}B, and cytokine expression Am J Physiol Cell Physiol, March 1, 2004; 286(3): C683 - C692. [Abstract] [Full Text]

				J.D. Crapo Oxidative stress as an initiator of cytokine release and cell damage Eur. Respir. J., September 20, 2003; 22(44_suppl): 4s - 6s. [Full Text] [PDF]

				M. J. Tobin Asthma, Airway Biology, and Nasal Disorders in AJRCCM 2002 Am. J. Respir. Crit. Care Med., February 1, 2003; 167(3): 319 - 332. [Full Text] [PDF]