help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Morrow, J. D.
Right arrow Articles by Roberts, L. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Morrow, J. D.
Right arrow Articles by Roberts, L. J.
American Journal of Respiratory and Critical Care Medicine Vol 166. pp. S25-S30, (2002)
© 2002 American Thoracic Society

Article

The Isoprostanes

Their Role as an Index of Oxidant Stress Status in Human Pulmonary Disease

Jason D. Morrow and L. Jackson Roberts

Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

Correspondence and requests for reprints should be addressed to Jason D. Morrow, M.D., 526 RRB, Vanderbilt University, 23rd and Pierce Avenues, Nashville, TN 37232–6602. E-mail: jason.morrow{at}mcmail.vanderbilt.edu

ABSTRACT

The isoprostanes are a unique series of prostaglandin-like compounds formed in vivo from the free radical–initiated peroxidation of arachidonic acid independent of the cyclooxygenase enzyme. This article summarizes selected aspects regarding our current knowledge of these compounds and what are considered avenues for future research. Novel aspects related to the biochemistry of isoprostane formation are discussed first, followed by a summary of methods by which these compounds are analyzed. A considerable portion of this article deals with the utility of measuring isoprostanes as markers of oxidant injury in vitro and in vivo, particularly in pulmonary diseases. Studies performed over the past decade have shown that these compounds are extremely accurate measures of lipid peroxidation in animals and humans and have illuminated the role of oxidant injury in a number of human diseases, including those related to the lung.

Key Words: lipid peroxidation • eicosanoids • isoprostanes • lipid




This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. E. Dennis, J. L. Aschner, D. Milatovic, J. W. Schmidt, M. Aschner, M. R. Kaplowitz, Y. Zhang, and C. D. Fike
NADPH oxidases and reactive oxygen species at different stages of chronic hypoxia-induced pulmonary hypertension in newborn piglets
Am J Physiol Lung Cell Mol Physiol, October 1, 2009; 297(4): L596 - L607.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
J. A. Voynow, B. M. Fischer, S. Zheng, E. N. Potts, A. R. Grover, A. K. Jaiswal, A. J. Ghio, and W. M. Foster
NAD(P)H Quinone Oxidoreductase 1 Is Essential for Ozone-Induced Oxidative Stress in Mice and Humans
Am. J. Respir. Cell Mol. Biol., July 1, 2009; 41(1): 107 - 113.
[Abstract] [Full Text] [PDF]

Home page
 Crop Sci.Home page
M. D. Thompson, M. A. Brick, J. N. McGinley, and H. J. Thompson
Chemical Composition and Mammary Cancer Inhibitory Activity of Dry Bean
Crop Sci., January 28, 2009; 49(1): 179 - 186.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. A. Birukova, E. Alekseeva, I. Cokic, C. E. Turner, and K. G. Birukov
Cross talk between paxillin and Rac is critical for mediation of barrier-protective effects by oxidized phospholipids
Am J Physiol Lung Cell Mol Physiol, October 1, 2008; 295(4): L593 - L602.
[Abstract] [Full Text] [PDF]

Home page
 Exp Biol MedHome page
R. Rodrigo, S. Trujillo, and C. Bosco
Biochemical and Ultrastructural Lung Damage Induced by Rhabdomyolysis in the Rat
Exp Biol Med, September 1, 2006; 231(8): 1430 - 1438.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Nonas, I. Miller, K. Kawkitinarong, S. Chatchavalvanich, I. Gorshkova, V. N. Bochkov, N. Leitinger, V. Natarajan, J. G. N. Garcia, and K. G. Birukov
Oxidized Phospholipids Reduce Vascular Leak and Inflammation in Rat Model of Acute Lung Injury
Am. J. Respir. Crit. Care Med., May 15, 2006; 173(10): 1130 - 1138.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
A. Sinha, K. Muthiah, W. Jiang, X. Couroucli, R. Barrios, and B. Moorthy
Attenuation of Hyperoxic Lung Injury by the CYP1A Inducer {beta}-Naphthoflavone
Toxicol. Sci., September 1, 2005; 87(1): 204 - 212.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. H. Ramsey, I. M. Sigar, S. V. Rana, J. Gupta, S. M. Holland, G. I. Byrne, and J. D. Morrow
Inducible Nitric Oxide Synthase Regulates Production of Isoprostanes In Vivo during Chlamydial Genital Infection in Mice
Infect. Immun., December 1, 2003; 71(12): 7183 - 7187.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Asthma, Airway Biology, and Nasal Disorders in AJRCCM 2002
Am. J. Respir. Crit. Care Med., February 1, 2003; 167(3): 319 - 332.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2002 American Thoracic Society