help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ranganathan, S. C.
Right arrow Articles by Stocks, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ranganathan, S. C.
Right arrow Articles by Stocks, J.
American Journal of Respiratory and Critical Care Medicine Vol 166. pp. 1350-1357, (2002)
© 2002 American Thoracic Society

Original Article

Relative Ability of Full and Partial Forced Expiratory Maneuvers to Identify Diminished Airway Function in Infants with Cystic Fibrosis

Sarath C. Ranganathan, Andrew Bush, Carol Dezateux, Siobhán B. Carr, Ah-Fong Hoo, Sooky Lum, Su Madge, John Price, John Stroobant, Angie Wade, Colin Wallis, Hilary Wyatt and Janet Stocks and the London Collaborative Cystic Fibrosis Group

Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, Institute of Child Health; Department of Paediatric Respiratory Medicine, Royal Brompton Hospital; Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health; Department of Child Health, Royal London Hospital; Neonatal Unit, Homerton University Hospital; Department of Paediatric Respiratory Medicine, Great Ormond Street Hospital; Department of Child Health, King's College Hospital; and Department of Child Health, University Hospital Lewisham, London, United Kingdom

Correspondence and requests for reprints should be addressed to Dr. Sarath Ranganathan, Portex Unit, 6th Floor, Cardiac Wing, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. E-mail: drsarath{at}clara.net

The tidal and raised volume rapid thoracoabdominal compression techniques are increasingly used to detect diminished airway function in infancy. The aim of this study was to assess the relative ability of parameters measured by these techniques to identify diminished airway function in infants newly diagnosed with cystic fibrosis (CF) with and without clinical evidence of prior lower respiratory illness. A cross-sectional, prospective study design was used in which maximal flow at functional residual capacity (VmaxFRC) from the tidal technique and FVC, FEV0.5, FEF75, and FEF25–75 from the raised volume technique were measured in 47 infants with CF and 187 healthy infants of similar body size, sex distribution, ethnic group, and exposure to maternal smoking. Multiple linear regression was used to assess group differences and to calculate SD scores for each parameter for the infants with CF. Airway function was also compared with clinical assessments of respiratory status made by pediatric pulmonologists. FEV0.5 was significantly diminished in 13 infants with CF, of whom 4 had been identified by clinicians as having normal respiratory status. Only one infant with CF had a VmaxFRC below the estimated normal range. Airway function is diminished in infants with CF irrespective of prior lower respiratory illness and in those whose respiratory status is considered normal by pediatric pulmonologists. In infants with CF, the raised volume technique identified diminished airway function more frequently than the tidal technique.

Key Words: cystic fibrosis • respiratory function tests • infant • early intervention • forced expiration




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bush
Update in Pediatric Lung Disease 2007
Am. J. Respir. Crit. Care Med., April 1, 2008; 177(7): 686 - 695.
[Full Text] [PDF]

Home page
 ChestHome page
W. Shi, S. Bellusci, and D. Warburton
Lung Development and Adult Lung Diseases
Chest, August 1, 2007; 132(2): 651 - 656.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
S. D. Davis, A. S. Brody, M. J. Emond, L. C. Brumback, and M. Rosenfeld
Endpoints for Clinical Trials in Young Children with Cystic Fibrosis
Proceedings of the ATS, August 1, 2007; 4(4): 418 - 430.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
S. Lum, P. Gustafsson, H. Ljungberg, G. Hulskamp, A. Bush, S. B Carr, R. Castle, A.-f. Hoo, J. Price, S. Ranganathan, et al.
Early detection of cystic fibrosis lung disease: multiple-breath washout versus raised volume tests
Thorax, April 1, 2007; 62(4): 341 - 347.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bush
Update in pediatrics 2005.
Am. J. Respir. Crit. Care Med., March 15, 2006; 173(6): 585 - 592.
[Full Text] [PDF]

Home page
 ChestHome page
L. Loland, F. F. Buchvald, L. Brydensholt Halkjaer, J. Anhoj, G. L. Hall, T. Persson, T. Grove Krause, and H. Bisgaard
Sensitivity of Bronchial Responsiveness Measurements in Young Infants
Chest, March 1, 2006; 129(3): 669 - 675.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. Friedrich, R. T. Stein, P. M. C. Pitrez, A. L. Corso, and M. H. Jones
Reduced Lung Function in Healthy Preterm Infants in the First Months of Life
Am. J. Respir. Crit. Care Med., February 15, 2006; 173(4): 442 - 447.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
ATS/ERS Statement: Raised Volume Forced Expirations in Infants: Guidelines for Current Practice
Am. J. Respir. Crit. Care Med., December 1, 2005; 172(11): 1463 - 1471.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. M. Martinez, C. J. Llapur, T. H. Williams, C. Coates, R. Gunderman, M. D. Cohen, M. S. Howenstine, O. Saba, H. O. Coxson, and R. S. Tepper
High-Resolution Computed Tomography Imaging of Airway Disease in Infants with Cystic Fibrosis
Am. J. Respir. Crit. Care Med., November 1, 2005; 172(9): 1133 - 1138.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
W. Hofhuis, E. C. van der Wiel, E. M. Nieuwhof, W. C. J. Hop, M. J. Affourtit, F. J. Smit, A. A. P. H. Vaessen-Verberne, F. G. A. Versteegh, J. C. de Jongste, P. J. F. M. Merkus, et al.
Efficacy of Fluticasone Propionate on Lung Function and Symptoms in Wheezy Infants
Am. J. Respir. Crit. Care Med., February 15, 2005; 171(4): 328 - 333.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
S Brennan, G L Hall, F Horak, A Moeller, P M C Pitrez, A Franzmann, S Turner, N de Klerk, P Franklin, K R Winfield, et al.
Correlation of forced oscillation technique in preschool children with cystic fibrosis with pulmonary inflammation
Thorax, February 1, 2005; 60(2): 159 - 163.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. Aurora, A. Bush, P. Gustafsson, C. Oliver, C. Wallis, J. Price, J. Stroobant, S. Carr, J. Stocks, and on behalf of the London Cystic Fibrosis Collaborat
Multiple-Breath Washout as a Marker of Lung Disease in Preschool Children with Cystic Fibrosis
Am. J. Respir. Crit. Care Med., February 1, 2005; 171(3): 249 - 256.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
P D Sly and S Brennan
Detecting early lung disease in cystic fibrosis: are current techniques sufficient?
Thorax, December 1, 2004; 59(12): 1008 - 1010.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A.-F. Hoo, J. Stocks, S. Lum, A. M. Wade, R. A. Castle, K. L. Costeloe, and C. Dezateux
Development of Lung Function in Early Life: Influence of Birth Weight in Infants of Nonsmokers
Am. J. Respir. Crit. Care Med., September 1, 2004; 170(5): 527 - 533.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. C. Ranganathan, J. Stocks, C. Dezateux, A. Bush, A. Wade, S. Carr, R. Castle, R. Dinwiddie, A.-F. Hoo, S. Lum, et al.
The Evolution of Airway Function in Early Childhood Following Clinical Diagnosis of Cystic Fibrosis
Am. J. Respir. Crit. Care Med., April 15, 2004; 169(8): 928 - 933.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S.C. Ranganathan, I. Goetz, A-F. Hoo, S. Lum, R. Castle, J. Stocks, and and the London Collaborative Cystic Fibrosis Group
Assessment of tidal breathing parameters in infants with cystic fibrosis
Eur. Respir. J., November 1, 2003; 22(5): 761 - 766.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. L. Gibson, J. L. Burns, and B. W. Ramsey
Pathophysiology and Management of Pulmonary Infections in Cystic Fibrosis
Am. J. Respir. Crit. Care Med., October 15, 2003; 168(8): 918 - 951.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
The Role of a Journal in a Scientific Controversy
Am. J. Respir. Crit. Care Med., September 1, 2003; 168(5): 511 - 511.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. Bar-Yishay, A.-F. Hoo, J. Stocks, T. Cole, C. Dezateux, R. Tepper, and S. Ranganathan
Prediction of maximum flow at functional residual capacity in infants: Normal range
Am. J. Respir. Crit. Care Med., July 1, 2003; 168(1): 129 - 132.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. H. Jones, J. Howard, S. Davis, J. Kisling, and R. S. Tepper
Sensitivity of Spirometric Measurements to Detect Airway Obstruction in Infants
Am. J. Respir. Crit. Care Med., May 1, 2003; 167(9): 1283 - 1286.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Pediatrics, Surfactant, and Cystic Fibrosis in AJRCCM 2002
Am. J. Respir. Crit. Care Med., February 1, 2003; 167(3): 333 - 344.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2002 American Thoracic Society