help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SCHALLER-BALS, S.
Right arrow Articles by BALS, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SCHALLER-BALS, S.
Right arrow Articles by BALS, R.

Am. J. Respir. Crit. Care Med., Volume 165, Number 7, April 2002, 992-995

Increased Levels of Antimicrobial Peptides in Tracheal Aspirates of Newborn Infants during Infection

SUSANNE SCHALLER-BALS, ANDREAS SCHULZE, and ROBERT BALS

Division of Neonatology, Department of Obstetrics and Gynecology, and Division of Pulmonology, Department of Medicine I, Hospital of the University of Munich, Großhadern, Ludwig-Maximilians-Universität, Munich, Germany

Pneumonia and systemic infection are common in premature infants. The antimicrobial peptides human beta -defensin 1 and 2 (hBD-1 and hBD-2) and the cathelicidin LL-37/hCAP-18 are effector molecules of the innate respiratory immune system. It is unknown whether these host defense substances are produced in the respiratory tract of newborns. Concentrations of these peptides were determined in tracheal aspirates of mechanically ventilated newborn infants. All three antimicrobial peptides could be detected in airway lining fluid with equivalent levels in term and preterm newborns. Concentrations of antimicrobial peptides correlated with each other and with levels of interleukin-8 and tumor necrosis factor-alpha in the bronchoalveolar lavage fluid. Pulmonary or systemic infections were associated with significantly increased concentrations of LL-37, hBD-1, and hBD-2. Western blotting detected mature peptides in the lavage fluid. In conclusion, mucosal antimicrobial peptides are present in lung secretions of premature and mature newborns. The molecules are upregulated in response to infection and inflammation and probably represent effector molecules of the respiratory defense system.




This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
Z. Zhang, G. Cherryholmes, and J. E. Shively
Neutrophil secondary necrosis is induced by LL-37 derived from cathelicidin
J. Leukoc. Biol., September 1, 2008; 84(3): 780 - 788.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Kota, A. Sabbah, T. H. Chang, R. Harnack, Y. Xiang, X. Meng, and S. Bose
Role of Human {beta}-Defensin-2 during Tumor Necrosis Factor-{alpha}/NF-{kappa}B-mediated Innate Antiviral Response against Human Respiratory Syncytial Virus
J. Biol. Chem., August 15, 2008; 283(33): 22417 - 22429.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
R. Bucki, D. B. Namiot, Z. Namiot, P. B. Savage, and P. A. Janmey
Salivary mucins inhibit antibacterial activity of the cathelicidin-derived LL-37 peptide but not the cationic steroid CSA-13
J. Antimicrob. Chemother., August 1, 2008; 62(2): 329 - 335.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
I. Nagaoka, F. Niyonsaba, Y. Tsutsumi-Ishii, H. Tamura, and M. Hirata
Evaluation of the effect of human {beta}-defensins on neutrophil apoptosis
Int. Immunol., April 1, 2008; 20(4): 543 - 553.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Yu, N. Mookherjee, K. Wee, D. M. E. Bowdish, J. Pistolic, Y. Li, L. Rehaume, and R. E. W. Hancock
Host Defense Peptide LL-37, in Synergy with Inflammatory Mediator IL-1beta, Augments Immune Responses by Multiple Pathways
J. Immunol., December 1, 2007; 179(11): 7684 - 7691.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
N. Mookherjee, H. L. Wilson, S. Doria, Y. Popowych, R. Falsafi, J. Yu, Y. Li, S. Veatch, F. M. Roche, K. L. Brown, et al.
Bovine and human cathelicidin cationic host defense peptides similarly suppress transcriptional responses to bacterial lipopolysaccharide
J. Leukoc. Biol., December 1, 2006; 80(6): 1563 - 1574.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
K. Kandler, R. Shaykhiev, P. Kleemann, F. Klescz, M. Lohoff, C. Vogelmeier, and R. Bals
The anti-microbial peptide LL-37 inhibits the activation of dendritic cells by TLR ligands
Int. Immunol., December 1, 2006; 18(12): 1729 - 1736.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
P. G. Barlow, Y. Li, T. S. Wilkinson, D. M. E. Bowdish, Y. E. Lau, C. Cosseau, C. Haslett, A. J. Simpson, R. E. W. Hancock, and D. J. Davidson
The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system
J. Leukoc. Biol., September 1, 2006; 80(3): 509 - 520.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
K. Edfeldt, B. Agerberth, M. E. Rottenberg, G. H. Gudmundsson, X.-B. Wang, K. Mandal, Q. Xu, and Z.-q. Yan
Involvement of the Antimicrobial Peptide LL-37 in Human Atherosclerosis
Arterioscler. Thromb. Vasc. Biol., July 1, 2006; 26(7): 1551 - 1557.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
L. C. Huang, T. D. Petkova, R. Y. Reins, R. J. Proske, and A. M. McDermott
Multifunctional Roles of Human Cathelicidin (LL-37) at the Ocular Surface.
Invest. Ophthalmol. Vis. Sci., June 1, 2006; 47(6): 2369 - 2380.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
Y. E. Lau, D. M. E. Bowdish, C. Cosseau, R. E. W. Hancock, and D. J. Davidson
Apoptosis of Airway Epithelial Cells: Human Serum Sensitive Induction by the Cathelicidin LL-37
Am. J. Respir. Cell Mol. Biol., April 1, 2006; 34(4): 399 - 409.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Mookherjee, K. L. Brown, D. M. E. Bowdish, S. Doria, R. Falsafi, K. Hokamp, F. M. Roche, R. Mu, G. H. Doho, J. Pistolic, et al.
Modulation of the TLR-Mediated Inflammatory Response by the Endogenous Human Host Defense Peptide LL-37
J. Immunol., February 15, 2006; 176(4): 2455 - 2464.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. Shaykhiev, C. Beisswenger, K. Kandler, J. Senske, A. Puchner, T. Damm, J. Behr, and R. Bals
Human endogenous antibiotic LL-37 stimulates airway epithelial cell proliferation and wound closure
Am J Physiol Lung Cell Mol Physiol, November 1, 2005; 289(5): L842 - L848.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
D. M. E. Bowdish, D. J. Davidson, Y. E. Lau, K. Lee, M. G. Scott, and R. E. W. Hancock
Impact of LL-37 on anti-infective immunity
J. Leukoc. Biol., April 1, 2005; 77(4): 451 - 459.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
S. van Wetering, G. S. Tjabringa, and P. S. Hiemstra
Interactions between neutrophil-derived antimicrobial peptides and airway epithelial cells
J. Leukoc. Biol., April 1, 2005; 77(4): 444 - 450.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. D. Starner, B. Agerberth, G. H. Gudmundsson, and P. B. McCray Jr.
Expression and Activity of {beta}-Defensins and LL-37 in the Developing Human Lung
J. Immunol., February 1, 2005; 174(3): 1608 - 1615.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
P C Ng
Diagnostic markers of infection in neonates
Arch. Dis. Child. Fetal Neonatal Ed., May 1, 2004; 89(3): F229 - F235.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. M. E. Bowdish, D. J. Davidson, D. P. Speert, and R. E. W. Hancock
The Human Cationic Peptide LL-37 Induces Activation of the Extracellular Signal-Regulated Kinase and p38 Kinase Pathways in Primary Human Monocytes
J. Immunol., March 15, 2004; 172(6): 3758 - 3765.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
R. Bals and P.S. Hiemstra
Innate immunity in the lung: how epithelial cells fight against respiratory pathogens
Eur. Respir. J., February 1, 2004; 23(2): 327 - 333.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. J. Davidson, A. J. Currie, G. S. D. Reid, D. M. E. Bowdish, K. L. MacDonald, R. C. Ma, R. E. W. Hancock, and D. P. Speert
The Cationic Antimicrobial Peptide LL-37 Modulates Dendritic Cell Differentiation and Dendritic Cell-Induced T Cell Polarization
J. Immunol., January 15, 2004; 172(2): 1146 - 1156.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. S. Tjabringa, J. Aarbiou, D. K. Ninaber, J. W. Drijfhout, O. E. Sorensen, N. Borregaard, K. F. Rabe, and P. S. Hiemstra
The Antimicrobial Peptide LL-37 Activates Innate Immunity at the Airway Epithelial Surface by Transactivation of the Epidermal Growth Factor Receptor
J. Immunol., December 15, 2003; 171(12): 6690 - 6696.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Pediatrics, Surfactant, and Cystic Fibrosis in AJRCCM 2002
Am. J. Respir. Crit. Care Med., February 1, 2003; 167(3): 333 - 344.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2002 American Thoracic Society 		  Solid Organ Transplant for the Intensivist 2008