help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by IMADOJEMU, V. A.
Right arrow Articles by LEUENBERGER, U. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by IMADOJEMU, V. A.
Right arrow Articles by LEUENBERGER, U. A.

Am. J. Respir. Crit. Care Med., Volume 165, Number 7, April 2002, 950-953

Impaired Vasodilator Responses in Obstructive Sleep Apnea Are Improved with Continuous Positive Airway Pressure Therapy

VIRGINIA A. IMADOJEMU, KEVIN GLEESON, SADEQ A. QURAISHI, ALLEN R. KUNSELMAN, LAWRENCE I. SINOWAY, and URS A. LEUENBERGER

Divisions of Pulmonary, Allergy and Critical Care and Cardiology, and Department of Health Evaluation Sciences, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania; and Lebanon Veterans Affairs Medical Center, Lebanon, Pennsylvania

Obstructive sleep apnea causes cardiovascular morbidity and premature death. Potential links between sleep apnea and cardiovascular complications are chronically elevated activity of the sympathetic nervous system and abnormal vascular function. To explore vascular function, we determined the reactive hyperemic blood flow (RHBF) responses to 10 minutes of forearm arterial occlusion (plethysmography), blood pressure, and muscle sympathetic nerve activity (MSNA, microneurography) in eight patients with sleep apnea and in nine nonapneic control subjects. Peak RHBF and vascular conductance were markedly attenuated in sleep apnea compared with control subjects (p < 0.05). Seven sleep apnea patients were retested after at least two weeks of continuous positive airway pressure (CPAP) therapy. MSNA decreased after CPAP therapy (p < 0.05, n = 6), whereas blood pressure did not change. After CPAP therapy, peak RHBF and vascular conductance were increased compared with before treatment (p < 0.05; n = 7). Thus, vascular function is abnormal in sleep apnea and is improved by CPAP therapy. Furthermore, effective CPAP therapy decreases sympathetic activity in sleep apnea. Thus, sympathoexcitation and abnormal vascular function in patients with sleep apnea appear to be linked to the repetitive nocturnal apneic events.




This article has been cited by other articles:


Home page
 Vasc MedHome page
H. A Chami, M. J Keyes, J. A Vita, G. F Mitchell, M. G Larson, S. Fan, R. S Vasan, G. T O'Connor, E. J Benjamin, and D. J Gottlieb
Brachial artery diameter, blood flow and flow-mediated dilation in sleep-disordered breathing
Vascular Medicine, November 1, 2009; 14(4): 351 - 360.
[Abstract] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Dematteis, C. Julien, C. Guillermet, N. Sturm, S. Lantuejoul, M. Mallaret, P. Levy, and E. Gozal
Intermittent Hypoxia Induces Early Functional Cardiovascular Remodeling in Mice
Am. J. Respir. Crit. Care Med., January 15, 2008; 177(2): 227 - 235.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Z. Dujic, V. Ivancev, K. Heusser, G. Dzamonja, I. Palada, Z. Valic, J. Tank, A. Obad, D. Bakovic, A. Diedrich, et al.
Central chemoreflex sensitivity and sympathetic neural outflow in elite breath-hold divers
J Appl Physiol, January 1, 2008; 104(1): 205 - 211.
[Abstract] [Full Text] [PDF]

Home page
 ERRHome page
B. Buyse, J. Hedner, and the participants of working group 2
Sleep apnoea, hypertension and vascular disease: where are we now?
Eur. Respir. Rev., December 1, 2007; 16(106): 169 - 182.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. Moradkhan, P. McQuillan, C. Hogeman, A. Leuenberger, L. Linton-Frazier, and U. A. Leuenberger
Metabolic forearm vasodilation is enhanced following Bier block with phentolamine
Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2289 - H2295.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. A. El Solh, M. E. Akinnusi, F. H. Baddoura, and C. R. Mankowski
Endothelial Cell Apoptosis in Obstructive Sleep Apnea: A Link to Endothelial Dysfunction
Am. J. Respir. Crit. Care Med., June 1, 2007; 175(11): 1186 - 1191.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
V. A. Imadojemu, Z. Mawji, A. Kunselman, K. S. Gray, C. S. Hogeman, and U. A. Leuenberger
Sympathetic Chemoreflex Responses in Obstructive Sleep Apnea and Effects of Continuous Positive Airway Pressure Therapy
Chest, May 1, 2007; 131(5): 1406 - 1413.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
H. Wang, J. D. Parker, G. E. Newton, J. S. Floras, S. Mak, K.-L. Chiu, P. Ruttanaumpawan, G. Tomlinson, and T. D. Bradley
Influence of Obstructive Sleep Apnea on Mortality in Patients With Heart Failure
J. Am. Coll. Cardiol., April 17, 2007; 49(15): 1625 - 1631.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. E. Foster, P. J. Hanly, M. Ostrowski, and M. J. Poulin
Effects of Continuous Positive Airway Pressure on Cerebral Vascular Response to Hypoxia in Patients with Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med., April 1, 2007; 175(7): 720 - 725.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. Itzhaki, H. Dorchin, G. Clark, L. Lavie, P. Lavie, and G. Pillar
The Effects of 1-Year Treatment With a Herbst Mandibular Advancement Splint on Obstructive Sleep Apnea, Oxidative Stress, and Endothelial Function
Chest, March 1, 2007; 131(3): 740 - 749.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
G. E. Foster, M. J. Poulin, and P. J. Hanly
Sleep Apnoea & Hypertension: Physiological bases for a causal relation: Intermittent hypoxia and vascular function: implications for obstructive sleep apnoea
Exp Physiol, January 1, 2007; 92(1): 51 - 65.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J L Lattimore, I Wilcox, M Skilton, M Langenfeld, and D S Celermajer
Treatment of obstructive sleep apnoea leads to improved microvascular endothelial function in the systemic circulation
Thorax, June 1, 2006; 61(6): 491 - 495.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. A. Phillips, E. B. Olson, J. H. Lombard, and B. J. Morgan
Chronic intermittent hypoxia alters NE reactivity and mechanics of skeletal muscle resistance arteries
J Appl Physiol, April 1, 2006; 100(4): 1117 - 1123.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. I. Pack
Advances in Sleep-disordered Breathing
Am. J. Respir. Crit. Care Med., January 1, 2006; 173(1): 7 - 15.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Arzt, T. Young, L. Finn, J. B. Skatrud, and T. D. Bradley
Association of Sleep-disordered Breathing and the Occurrence of Stroke
Am. J. Respir. Crit. Care Med., December 1, 2005; 172(11): 1447 - 1451.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. M. Oltmanns, H. Gehring, S. Rudolf, B. Schultes, S. Rook, U. Schweiger, J. Born, H. L. Fehm, and A. Peters
Hypoxia Causes Glucose Intolerance in Humans
Am. J. Respir. Crit. Care Med., June 1, 2004; 169(11): 1231 - 1237.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. S. Hui, F. W. Ko, J. P. Fok, M. C. Chan, T. S. Li, B. Tomlinson, and G. Cheng
The Effects of Nasal Continuous Positive Airway Pressure on Platelet Activation in Obstructive Sleep Apnea Syndrome
Chest, May 1, 2004; 125(5): 1768 - 1775.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. Tamisier, D. Norman, A. Anand, Y. Choi, and J. W. Weiss
Evidence of sustained forearm vasodilatation after brief isocapnic hypoxia
J Appl Physiol, May 1, 2004; 96(5): 1782 - 1787.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. S. Amin, J. L. Carroll, J. L. Jeffries, C. Grone, J. A. Bean, B. Chini, R. Bokulic, and S. R. Daniels
Twenty-four-hour Ambulatory Blood Pressure in Children with Sleep-disordered Breathing
Am. J. Respir. Crit. Care Med., April 15, 2004; 169(8): 950 - 956.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
V. A. Imadojemu, L. I. Sinoway, and U. A. Leuenberger
Vascular Dysfunction in Sleep Apnea: A Reversible Link to Cardiovascular Disease?
Am. J. Respir. Crit. Care Med., February 1, 2004; 169(3): 328 - 329.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. J. Nieto, D. M. Herrington, S. Redline, E. J. Benjamin, and J. A. Robbins
Sleep Apnea and Markers of Vascular Endothelial Function in a Large Community Sample of Older Adults
Am. J. Respir. Crit. Care Med., February 1, 2004; 169(3): 354 - 360.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. S. M. Ip, H.-F. Tse, B. Lam, K. W. T. Tsang, and W.-K. Lam
Endothelial Function in Obstructive Sleep Apnea and Response to Treatment
Am. J. Respir. Crit. Care Med., February 1, 2004; 169(3): 348 - 353.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
T. D. Bradley and J. S. Floras
Sleep Apnea and Heart Failure: Part I: Obstructive Sleep Apnea
Circulation, April 1, 2003; 107(12): 1671 - 1678.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Sleep-Disordered Breathing, Control of Breathing, Respiratory Muscles, and Pulmonary Function Testing in AJRCCM 2002
Am. J. Respir. Crit. Care Med., February 1, 2003; 167(3): 306 - 318.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2002 American Thoracic Society 		  New Orleans Int'l Conf