help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Online Data Supplement
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by BOUFERRACHE, B.
Right arrow Articles by GAULTIER, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BOUFERRACHE, B.
Right arrow Articles by GAULTIER, C.

Am. J. Respir. Crit. Care Med., Volume 165, Number 2, January 2002, 206-210

Comparison of the Hyperoxic Test and the Alternate Breath Test in Infants

BELKACEM BOUFERRACHE, SLAVI FILTCHEV, ANDRÉ LEKE, MICHEL FREVILLE, JORGE GALLEGO, and CLAUDE GAULTIER

Unite de Recherches sur les Adaptations Physiologiques et Comportementales (EA 2088), School of Medicine, Amiens, and Department of Physiology, INSERM E9935, Robert Debré Hospital, Paris, France

Peripheral chemoreceptor function has been tested using either the hyperoxic test (HT), which decreases minute ventilation (V E) by causing physiologic chemodenervation, or the alternate breath test (ABT), which induces V E alternations by delivering rapid hypoxic stimuli through breath-by-breath alternations in fractional inspired O2 between normoxia (0.21) and hypoxia (0.15). No previous studies have compared ventilatory responses to both tests in the same infants. We hypothesized that the V E decrease during HT would be significantly related to V E alternations during ABT. Eighteen infants (postnatal age 21 ± 14 d) underwent two 30-s HTs and two ABTs (quiet sleep, face mask, and pneumotachograph; mass spectrometry measurement of inspired and expired O2 and CO2 fractions; and breath-by-breath analysis). The tests were done in random order. Decreases in V E and mean inspiratory flow (tidal volume over inspiratory time, VT/TI) during HTs were significantly correlated to their respective percentage coefficients of alternation during ABTs (r = 0.69 and 0.70, respectively, p < 0.01). Principal components analysis showed that the V E and VT/TI decreases during HTs were due chiefly to a fall in VT, whereas V E and VT/TI alternations were ascribable to alternations in both VT and TI. Intraindividual coefficients of variation of V E changes were significantly lower during HTs than during ABTs. We conclude that (1) ventilatory responses to HT and ABT are significantly correlated despite differences in the mechanisms of the V E changes; (2) the better reproducibility of the V E response to HT as compared with ABT may be an advantage in clinical practice.




This article has been cited by other articles:


Home page
 Eur Respir JHome page
B. Fauroux and A. Clement
Requisite for stringent control of oxygen therapy in the neonatal period
Eur. Respir. J., January 1, 2007; 29(1): 4 - 5.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. Chardon, V. Bach, F. Telliez, V. Cardot, P. Tourneux, A. Leke, and J.-P. Libert
Effect of caffeine on peripheral chemoreceptor activity in premature neonates: interaction with sleep stages
J Appl Physiol, June 1, 2004; 96(6): 2161 - 2166.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Pediatrics, Surfactant, and Cystic Fibrosis in AJRCCM 2002
Am. J. Respir. Crit. Care Med., February 1, 2003; 167(3): 333 - 344.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2002 American Thoracic Society 		  New Orleans Int'l Conf