This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Beydon, N. Articles by Gaultier, C. Search for Related Content PubMed PubMed Citation Articles by Beydon, N. Articles by Gaultier, C.

Pre/Postbronchodilator Interrupter Resistance Values in Healthy Young Children

Physiology Departments of the Robert Debré Teaching Hospital, Saint-Vincent-de-Paul Teaching Hospital, and Trousseau Teaching Hospital, Paris; Public Health Department of the Robert Debré Teaching Hospital, Paris; Pediatric Department, Arnaud de Villeneuve Teaching Hospital, Montpellier; Physiology Departments, Morvan Teaching Hospital, Brest; Poitiers Teaching Hospital, Poitiers; Calmette Teaching Hospital, Lille; and Grenoble Teaching Hospital, Grenoble, France

Correspondence should be addressed to Claude Gaultier, Service de Physiologie, Hôpital Robert Debré, 48 Bd Serurier, 75019, Paris, France. E-mail: claude.gaultier{at}rdb.ap-hop-paris.fr

The interrupter technique estimates flow resistance. It entails occlusion of the airways during tidal breathing while flow and mouth pressure are recorded. This noninvasive technique is easy to use in young children. The aim of the present study was to measure inspiratory and expiratory interrupter resistance (Rint_insp, Rint_exp) before and after bronchodilator administration in young healthy white children. We designed a multicenter study using a standardized procedure for Rint measurements. Centers in five French cities studied 91 children (48 boys and 43 girls; height, 92 to 129 cm; mean age 5.3 ± 1.4 years). Mean values were not significantly different for Rint_insp and Rint_exp (0.78 ± 0.21 versus 0.78 ± 0.20 KPa · L^-1 · second). However, the difference between Rint_insp and Rint_exp decreased significantly with age and being positive before 5 years and negative later on (p < 0.02). Rint_insp and Rint_exp decreased significantly with height (Rint_insp [KPa · L^-1 · second] = 2.289 - 1.37 . 10^-2 · H [cm], Rint_exp [KPa · L^-1 · second] = 2.021 - 1.12.10^-2 · H [cm]; p < 0.001). Bronchodilator (salbutamol) administration significantly decreased Rint_insp and Rint_exp (p < 0.001). Bronchodilator-induced changes (% of predicted values) in mean Rint_insp and mean Rint_exp were -15% (95% confidence interval, -46 to +15%) and -12% (95% confidence interval, -46 to +22%), respectively. Sex did not affect pre- or postbronchodilator values. Data from the present study may prove useful for testing lung function in young children with respiratory disorders who failed to cooperate with forced expiratory maneuvers.

Key Words: inspiratory and expiratory interrupter resistance • reference values • preschool children

This article has been cited by other articles:

				C. Thamrin, C. L Gangell, K. Udomittipong, M. M H Kusel, H. Patterson, T. Fukushima, A. Schultz, G. L Hall, S. M Stick, and P. D Sly Assessment of bronchodilator responsiveness in preschool children using forced oscillations Thorax, September 1, 2007; 62(9): 814 - 819. [Abstract] [Full Text] [PDF]

				S. D. Davis, A. S. Brody, M. J. Emond, L. C. Brumback, and M. Rosenfeld Endpoints for Clinical Trials in Young Children with Cystic Fibrosis Proceedings of the ATS, August 1, 2007; 4(4): 418 - 430. [Abstract] [Full Text] [PDF]

				N. Beydon, S. D. Davis, E. Lombardi, J. L. Allen, H. G. M. Arets, P. Aurora, H. Bisgaard, G. M. Davis, F. M. Ducharme, H. Eigen, et al. An Official American Thoracic Society/European Respiratory Society Statement: Pulmonary Function Testing in Preschool Children Am. J. Respir. Crit. Care Med., June 15, 2007; 175(12): 1304 - 1345. [Full Text] [PDF]

				M R Thomas, G F Rafferty, R Blowes, J L Peacock, N Marlow, S Calvert, A Milner, and A Greenough Plethysmograph and interrupter resistance measurements in prematurely born young children Arch. Dis. Child. Fetal Neonatal Ed., May 1, 2006; 91(3): F193 - F196. [Abstract] [Full Text] [PDF]

				D. A. Straub, S. Minocchieri, A. Moeller, J. Hamacher, and J. H. Wildhaber The Effect of Montelukast on Exhaled Nitric Oxide and Lung Function in Asthmatic Children 2 to 5 Years Old Chest, February 1, 2005; 127(2): 509 - 514. [Abstract] [Full Text] [PDF]

				J. E. Brussee, H. A. Smit, L. P. Koopman, A. H. Wijga, M. Kerkhof, K. Corver, A. P. H. Vos, J. Gerritsen, D. E. Grobbee, B. Brunekreef, et al. Interrupter Resistance and Wheezing Phenotypes at 4 Years of Age Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 209 - 213. [Abstract] [Full Text] [PDF]

				N. Beydon, I. Pin, R. Matran, M. Chaussain, M. Boule, B. Alain, M. Bellet, F. Amsallem, C. Alberti, A. Denjean, et al. Pulmonary Function Tests in Preschool Children with Asthma Am. J. Respir. Crit. Care Med., September 15, 2003; 168(6): 640 - 644. [Abstract] [Full Text] [PDF]

				P. D. Bridge, S. A. McKenzie, N. Beydon, C. Alberti, and C. Gaultier Time for standardization Am. J. Respir. Crit. Care Med., February 15, 2003; 167(4): 666 - 666. [Full Text]

				M. J. Tobin Pediatrics, Surfactant, and Cystic Fibrosis in AJRCCM 2002 Am. J. Respir. Crit. Care Med., February 1, 2003; 167(3): 333 - 344. [Full Text] [PDF]

				N. Beydon, F. Amsallem, M. Bellet, M. Boule, M. Chaussain, A. Denjean, R. Matran, I. Pin, C. Alberti, and C. Gaultier Pulmonary Function Tests in Preschool Children with Cystic Fibrosis Am. J. Respir. Crit. Care Med., October 15, 2002; 166(8): 1099 - 1104. [Abstract] [Full Text] [PDF]