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American Journal of Respiratory and Critical Care Medicine Vol 165. pp. 1371-1376, (2002)
© 2002 American Thoracic Society

Original Article

Effect of Theophylline on Induced Sputum Inflammatory Indices and Neutrophil Chemotaxis in Chronic Obstructive Pulmonary Disease

Sarah V. Culpitt, Carmen de Matos, Richard E. Russell, Louise E. Donnelly, Duncan F. Rogers and Peter J. Barnes

Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London, United Kingdom

Correspondence and requests for reprints should be addressed to Sarah V. Culpitt, Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, SW3 6LY, London, UK. E-mail: duncan.rogers{at}ic.ac.uk

Chronic obstructive pulmonary disease (COPD) is characterized by a neutrophilic airway inflammation that can be demonstrated by examination of induced sputum. Theophylline has antiinflammatory effects in asthma, and in the present study we investigated whether a similar effect occurs in COPD patients treated with low doses of theophylline. Twenty-five patients with COPD were treated with theophylline (plasma level of 9–11 mg/L) for 4 weeks in a placebo-controlled, randomized, double-blind crossover study. Theophylline was well tolerated. Induced sputum inflammatory cells, neutrophils, interleukin-8, myeloperoxidase, and lactoferrin were all significantly reduced by about 22% by theophylline. Neutrophils from subjects treated with theophylline showed reduced chemotaxis to N-formyl-met-leu-phe (~ 28%) and interleukin-8 (~ 60%). Neutrophils from a healthy donor showed reduced chemotaxis (~ 30%) to induced sputum samples obtained during theophylline treatment. These results suggest that theophylline has antiinflammatory properties that may be useful in the long-term treatment of COPD.

Key Words: COPD • sputum • theophylline • neutrophil • chemotaxis




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