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Am. J. Respir. Crit. Care Med., Volume 164, Number 8, October 2001, S12-S17

Anti-Immunoglobulin E (Omalizumab) Therapy in Allergic Asthma

WILLIAM W. BUSSE

Department of Medicine, Allergy and Immunology Section, University of Wisconsin Medical School, Madison, Wisconsin

Several large-scale, double-blind, randomized, placebo-controlled clinical trials of the anti-immunoglobulin E (IgE) monoclonal antibody, rhuMAb-E25 (omalizumab) have demonstrated the benefits of this agent in patients with moderate to severe allergic asthma who remain symptomatic despite treatment with systemic or inhaled corticosteroids. The trials have consistently shown that administration of omalizumab is associated with fewer asthma exacerbations per patient despite significant reductions in corticosteroid dose, stable symptom control despite concomitant reductions in rescue medication use, and improvement in quality of life compared with placebo. In addition, anti-IgE (omalizumab) has been shown to be safe and well tolerated.




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