help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by LAVOIE, J.-P.
Right arrow Articles by HAMID, Q. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by LAVOIE, J.-P.
Right arrow Articles by HAMID, Q. A.

Am. J. Respir. Crit. Care Med., Volume 164, Number 8, October 2001, 1410-1413

Neutrophilic Airway Inflammation in Horses with Heaves Is Characterized by a Th2-type Cytokine Profile

JEAN-PIERRE LAVOIE, KARIM MAGHNI, MICHEL DESNOYERS, RAME TAHA, JAMES G. MARTIN, and QUTAYBA A. HAMID

Faculté de Médecine Vétérinaire, Université de Montréal, St-Hyacinthe, Québec, Canada, and Meakins-Christie Laboratories, McGill University, Montreal, Québec, Canada

Heaves in horses shares many similarities with human asthma, including lower airway inflammation, reversible airway obstruction, and bronchial hyperresponsiveness. Extrinsic asthma is an allergic response to environmental allergens and a similar immunologic mechanism may be implicated in heaves. It is now recognized that a Th2 subset of CD4+ lymphocytes is associated with allergic diseases such as atopic asthma. The purpose of this study was to determine whether airway inflammation in heaves is associated with a pattern of expression of cytokine suggestive of a Th2 type response. The expression of mRNA, encoding interleukin (IL)-4, IL-5, and interferon gamma (IFN-gamma ) was measured in bronchoalveolar cells from seven horses with heaves and five control horses, using in situ hybridization and radiolabeled equine-specific cRNA probes coding for these cytokines. Bronchoalveolar cells of horses with heaves had an increased expression of IL-4 (p = 0.01) and IL-5 (p = 0.02) mRNA and a decreased expression of INF-gamma (p = 0.01) compared with control horses. Here we show that inflammatory cells in lungs from horses with heaves display a Th2-type cytokine profile that is consistent with the hypothesis that heaves is an allergic condition with similarity to human asthma.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H. Huang, A. Lavoie-Lamoureux, K. Moran, and J.-P. Lavoie
IL-4 stimulates the expression of CXCL-8, E-selectin, VEGF, and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells
Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1147 - L1154.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
E. D. Fixman, A. Stewart, and J. G. Martin
Basic mechanisms of development of airway structural changes in asthma
Eur. Respir. J., February 1, 2007; 29(2): 379 - 389.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. S. Davis, J. R. Malayer, L. Vandeventer, C. M. Royer, E. C. McKenzie, and K. K. Williamson
Cold weather exercise and airway cytokine expression
J Appl Physiol, June 1, 2005; 98(6): 2132 - 2136.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
M G Kelly, J S Elborn, M G Kelly, V Brown, M Ennis, and F Bureau
Measuring granulocyte apoptosis in airway inflammation
Thorax, April 1, 2002; 57(4): 376 - 376.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Asthma, Airway Biology, and Nasal Disorders in AJRCCM 2001
Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 598 - 618.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2001 American Thoracic Society