help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by JIANG, T.-X.
Right arrow Articles by ROAD, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by JIANG, T.-X.
Right arrow Articles by ROAD, J. D.

Am. J. Respir. Crit. Care Med., Volume 164, Number 7, October 2001, 1288-1294

Free Radical Scavengers and Diaphragm Injury Following Inspiratory Resistive Loading

TIAN-XI JIANG, W. DARLENE REID, and JEREMY D. ROAD

Department of Medicine and School of Rehabilitation Sciences, University of British Columbia, Vancouver, British Columbia, Canada

Three groups of NZW rabbits were studied to examine the role of free radical scavengers in preventing diaphragm injury produced by inspiratory resistive load (IRL): control, IRL, and scavenger groups. An IRL (Pao: 45-55 cm H2O) was applied to the IRL and the scavenger groups on Day 1. Free radical scavengers (polyethylene glycol superoxide dismutase, N-acetylcysteine, and mannitol) were given (intravenously) to the scavenger group both before and after the IRL. All rabbits were killed on Day 3 to collect diaphragms. Point counting H&E-stained diaphragm x-sections indicated that abnormal diaphragm muscle in the IRL group was significantly greater than control (p < 0.01). However, it was significantly lower in the scavenger group than the IRL group (p < 0.05) and it did not differ from control. In vitro diaphragm physiological studies found that the twitch tension (p < 0.05) and maximal tension (p < 0.01) in the IRL group were significantly lower than control. The maximal tensions (p < 0.05) in the scavenger group were lower than control. After the fatigue protocol, diaphragmatic contractility in the scavenger group was similar to control and was better maintained compared with the IRL group. We conclude that free radical scavengers can prevent the development of diaphragm injury as evidenced by histology but the protection of diaphragm function is limited.




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
T. Vassilakopoulos and S. N. A. Hussain
Ventilatory muscle activation and inflammation: cytokines, reactive oxygen species, and nitric oxide
J Appl Physiol, April 1, 2007; 102(4): 1687 - 1695.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
J. D. Pierce, C. Goodyear-Bruch, S. Hall, and R. L. Clancy
Effect of dopamine on rat diaphragm apoptosis and muscle performance
Exp Physiol, July 1, 2006; 91(4): 731 - 740.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T. Vassilakopoulos, C. Roussos, and S. Zakynthinos
The immune response to resistive breathing
Eur. Respir. J., December 1, 2004; 24(6): 1033 - 1043.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Vassilakopoulos, M. Divangahi, G. Rallis, O. Kishta, B. Petrof, A. Comtois, and S. N. A. Hussain
Differential Cytokine Gene Expression in the Diaphragm in Response to Strenuous Resistive Breathing
Am. J. Respir. Crit. Care Med., July 15, 2004; 170(2): 154 - 161.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Vassilakopoulos and B. J. Petrof
Ventilator-induced Diaphragmatic Dysfunction
Am. J. Respir. Crit. Care Med., February 1, 2004; 169(3): 336 - 341.
[Full Text] [PDF]

Home page
 J. Physiol.Home page
J. A. Simpson, J. Van Eyk, and S. Iscoe
Respiratory muscle injury, fatigue and serum skeletal troponin I in rat
J. Physiol., February 1, 2004; 554(3): 891 - 903.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. Laghi and M. J. Tobin
Disorders of the Respiratory Muscles
Am. J. Respir. Crit. Care Med., July 1, 2003; 168(1): 10 - 48.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Compliance (COMmunicate PLease wIth Less Abbreviations, Noun Clusters, and Exclusiveness)
Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): 1534 - 1536.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Vassilakopoulos, P. Katsaounou, M.-H. Karatza, A. Kollintza, S. Zakynthinos, and C. Roussos
Strenuous Resistive Breathing Induces Plasma Cytokines: Role of Antioxidants and Monocytes
Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): 1572 - 1578.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. B. Reid, J. Lannergren, and H. Westerblad
Respiratory and Limb Muscle Weakness Induced by Tumor Necrosis Factor-{alpha}: Involvement of Muscle Myofilaments
Am. J. Respir. Crit. Care Med., August 15, 2002; 166(4): 479 - 484.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Sleep-Disordered Breathing, Control of Breathing, Respiratory Muscles, and Pulmonary Function Testing in AJRCCM 2001
Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 584 - 597.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2001 American Thoracic Society 		  Subscribe to PATS