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Am. J. Respir. Crit. Care Med., Volume 164, Number 7, October 2001, 1114-1118

Reduced Muscle Redox Capacity after Endurance Training in Patients with Chronic Obstructive Pulmonary Disease

ROBERTO A. RABINOVICH, ESTHER ARDITE, THIERRY TROOSTERS, NEUS CARBÓ, JULI ALONSO, JOSÉ MANUEL GONZALEZ DE SUSO, JORDI VILARÓ, JOAN ALBERT BARBERÀ, MAITE FIGUERAS POLO, JOSEP M. ARGILÉS, JOSÉ C. FERNANDEZ-CHECA, and JOSEP ROCA

Servei de Pneumologia (ICPCT) and Liver Unit (IMD) and CSIC, Hospital Clinic, Facultat de Medicina, IDIBAPS, and Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona; Faculty of Physical Education and Physiotherapy, KUL, Leuven, Belgium; EUIF Blanquerna, Universitat Ramon Llull, Barcelona; Centre Diagnostic Pedralbes, Barcelona; and Centre d'Alt Rendiment, Sant Cugat del Vallès, Barcelona, Spain

The present study was undertaken to test whether endurance training in patients with COPD, along with enhancement of muscle bioenergetics, decreases muscle redox capacity as a result of recurrent episodes of cell hypoxia induced by high intensity exercise sessions. Seventeen patients with COPD (FEV1, 38 ± 4% pred; PaO2, 69 ± 2.7 mm Hg; PaCO2,42 ± 1.7 mm Hg) and five age-matched control subjects (C) were studied pretraining and post-training. Reduced (GSH) and oxidized (GSSG) glutathione, lipid peroxidation, and gamma-glutamyl cysteine synthase heavy subunit chain mRNA expression (gamma GCS-HS mRNA) were measured in the vastus lateralis. Pretraining redox status at rest and after moderate (40% Wpeak) constant-work rate exercise were similar between groups. After training (Delta Wpeak, 27 ± 7% and 37 ± 18%, COPD and C, respectively) (p < 0.05 each), GSSG levels increased only in patients with COPD (from 0.7 ± 0.08 to 1.0 ± 0.15 nmol/ mg protein, p < 0.05) with maintenance of GSH levels, whereas GSH markedly increased in C (from 4.6 ± 1.03 to 8.7 ± 0.41 nmol/ mg protein, p < 0.01). Post-training gamma GCS-HS mRNA levels increased after submaximal exercise in patients with COPD. No evidence of lipid peroxidation was observed. We conclude that although endurance training increased muscle redox potential in healthy subjects, patients with COPD showed a reduced ability to adapt to endurance training reflected in lower capacity to synthesize GSH.




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