help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by CARMELLI, D.
Right arrow Articles by REED, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by CARMELLI, D.
Right arrow Articles by REED, T.

Am. J. Respir. Crit. Care Med., Volume 164, Number 6, September 2001, 949-952

Genetic Factors in Self-reported Snoring and Excessive Daytime Sleepiness
A Twin Study

DORIT CARMELLI, DONALD L. BLIWISE, GARY E. SWAN, and TERRY REED

SRI International, Menlo Park, California; Emory University Medical Center, Atlanta, Georgia; and Indiana University, Indianapolis, Indiana

Subjects in this study included 1,560 intact male-male twin pairs (818 monozygotic [MZ], 742 dizygotic [DZ]) of mean age (± SD) 74.2 ± 2.8 yr. The Epworth Sleepiness Scale (ESS) was used to assess daytime sleepiness and standardized questionnaires assessed snoring. Multivariate genetic model fitting was used to estimate the contribution of genetic and nongenetic (environmental) influences to the variation and covariation of obesity with snoring and daytime sleepiness. In this sample, 26% were habitual snorers, 18% reported excessive daytime sleepiness (ESS >=  11), and 29% were obese (body mass index [BMI] >=  28). By using structural equation modeling, we estimated that genetic factors accounted for 64% of the variance in obesity, 40% of the variance in daytime sleepiness, and 23% of the variability in self-reports of snoring. We found a significant genetic correlation between obesity and snoring and between obesity and excessive daytime sleepiness (EDS), although for the most part the genetic variance in snoring and sleepiness was nonoverlapping with the genetic variance for obesity. We conclude from these data that self-reported symptoms of snoring and daytime sleepiness in older men have a genetic basis that is largely independent of genes associated with obesity.




This article has been cited by other articles:


Home page
 Eur Respir JHome page
P. Jennum and R. L. Riha
Epidemiology of sleep apnoea/hypopnoea syndrome and sleep-disordered breathing
Eur. Respir. J., April 1, 2009; 33(4): 907 - 914.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Compliance (COMmunicate PLease wIth Less Abbreviations, Noun Clusters, and Exclusiveness)
Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): 1534 - 1536.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Gislason, J. H. Johannsson, A. Haraldsson, B. R. Olafsdottir, H. Jonsdottir, A. Kong, M. L. Frigge, G. M. Jonsdottir, H. Hakonarson, J. Gulcher, et al.
Familial Predisposition and Cosegregation Analysis of Adult Obstructive Sleep Apnea and the Sudden Infant Death Syndrome
Am. J. Respir. Crit. Care Med., September 15, 2002; 166(6): 833 - 838.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Sleep-Disordered Breathing, Control of Breathing, Respiratory Muscles, and Pulmonary Function Testing in AJRCCM 2001
Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 584 - 597.
[Full Text] [PDF]

Home page
 Am J EpidemiolHome page
K. P. Strohl
Invited Commentary: To Sleep, Perchance to Discover
Am. J. Epidemiol., March 1, 2002; 155(5): 394 - 395.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2001 American Thoracic Society 		  Red Transition