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Am. J. Respir. Crit. Care Med., Volume 164, Number 3, August 2001, 474-477

Airway Smooth Muscle Cell Proliferation Is Increased in Asthma

PETER R. A. JOHNSON, MICHAEL ROTH, MICHAEL TAMM, MARGARET HUGHES, QI GE, GREG KING, JANETTE K. BURGESS, and JUDITH L. BLACK

Departments of Pharmacology and Pharmacy, University of Sydney, Institute of Respiratory Medicine, Royal Prince Alfred Hospital, Sydney, Australia

Increased airway smooth muscle (ASM) within the bronchial wall of asthmatic patients has been well documented and is likely to be the result of increased muscle proliferation. We have for the first time been able to culture ASM cells from asthmatic patients and to compare their proliferation rate with that of nonasthmatic patients. Asthmatic ASM cell cultures (n = 12) were established from explanted lungs and endobronchial biopsies. Nonasthmatic ASM cells (n = 10) were obtained from explanted tissue from patients with no airway disease, emphysema, carcinoma, and fibrosing alveolitis. Cell counts, tritiated thymidine incorporation, and cell cycle analysis were conducted over 7 d. Asthmatic ASM cell numbers at Days 3, 5, and 7 were significantly higher than corresponding values for nonasthmatic cells (p < 0.05). Tritiated thymidine incorporation was increased 3.2-fold in asthmatic cells compared with nonasthmatic cells within the first 24 h (p = 0.026). Flow cytometric analysis of DNA content on Days 1 and 2 revealed that a significantly greater percentage of asthmatic ASM cells were in the G2 + M phase (p < 0.05). This study shows for the first time that proliferation of ASM cells is increased in patients with asthma and provides evidence for an intrinsic abnormality in the ASM cell in this disease.

Keywords: asthma; human airway smooth muscle; cell culture; cell proliferation; hyperplasia




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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

Home page
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[Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

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[Full Text] [PDF]

Home page
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[Full Text] [PDF]

Home page
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N. Engl. J. Med., August 5, 2004; 351(6): 560 - 574.
[Abstract] [Full Text] [PDF]

Home page
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Am. J. Respir. Crit. Care Med., May 1, 2004; 169(9): 980 - 981.
[Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Proceedings of the ATS, April 1, 2004; 1(2): 77 - 87.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

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[Full Text] [PDF]

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Methods for the Assessment of Endobronchial Biopsies in Clinical Research: Application to Studies of Pathogenesis and the Effects of Treatment
Am. J. Respir. Crit. Care Med., September 15, 2003; 168(6): S1 - 17.
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 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. S. Chambers, J. L. Black, Q. Ge, S. M. Carlin, W. W. Au, M. Poniris, J. Thompson, P. R. Johnson, and J. K. Burgess
PAR-2 activation, PGE2, and COX-2 in human asthmatic and nonasthmatic airway smooth muscle cells
Am J Physiol Lung Cell Mol Physiol, September 1, 2003; 285(3): L619 - L627.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
C. Taille, A. Almolki, M. Benhamed, C. Zedda, J. Megret, P. Berger, G. Leseche, E. Fadel, T. Yamaguchi, R. Marthan, et al.
Heme Oxygenase Inhibits Human Airway Smooth Muscle Proliferation via a Bilirubin-dependent Modulation of ERK1/2 Phosphorylation
J. Biol. Chem., July 11, 2003; 278(29): 27160 - 27168.
[Abstract] [Full Text] [PDF]

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 Am. J. Respir. Cell Mol. Bio.Home page
J. M. Madison
Migration of Airway Smooth Muscle Cells
Am. J. Respir. Cell Mol. Biol., July 1, 2003; 29(1): 8 - 11.
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 ThoraxHome page
S T Holgate, D E Davies, G Murphy, R M Powell, and J W Holloway
ADAM 33: just another asthma gene or a breakthrough in understanding the origins of bronchial hyperresponsiveness?
Thorax, June 1, 2003; 58(6): 466 - 469.
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 Am. J. Respir. Crit. Care Med.Home page
L. Benayoun, A. Druilhe, M.-C. Dombret, M. Aubier, and M. Pretolani
Airway Structural Alterations Selectively Associated with Severe Asthma
Am. J. Respir. Crit. Care Med., May 15, 2003; 167(10): 1360 - 1368.
[Abstract] [Full Text] [PDF]

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 Am. J. Respir. Crit. Care Med.Home page
J. K. Burgess, P. R. A. Johnson, Q. Ge, W. W. Au, M. H. Poniris, B. E. McParland, G. King, M. Roth, and J. L. Black
Expression of Connective Tissue Growth Factor in Asthmatic Airway Smooth Muscle Cells
Am. J. Respir. Crit. Care Med., January 1, 2003; 167(1): 71 - 77.
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 Am. J. Respir. Crit. Care Med.Home page
K. Parameswaran, G. Cox, K. Radford, L. J. Janssen, R. Sehmi, and P. M. O'Byrne
Cysteinyl Leukotrienes Promote Human Airway Smooth Muscle Migration
Am. J. Respir. Crit. Care Med., September 1, 2002; 166(5): 738 - 742.
[Abstract] [Full Text] [PDF]

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 NEJMHome page
J. Black
The Role of Mast Cells in the Pathophysiology of Asthma
N. Engl. J. Med., May 30, 2002; 346(22): 1742 - 1743.
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 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Asthma, Airway Biology, and Nasal Disorders in AJRCCM 2001
Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 598 - 618.
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 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Page, A. J. Ammit, J. L. Black, and C. L. Armour
Human mast cell and airway smooth muscle cell interactions: implications for asthma
Am J Physiol Lung Cell Mol Physiol, December 1, 2001; 281(6): L1313 - L1323.
[Abstract] [Full Text] [PDF]

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 Am. J. Respir. Crit. Care Med.Home page
J. L. BLACK, M. ROTH, J. LEE, S. CARLIN, and P. R. A. JOHNSON
Mechanisms of Airway Remodeling . Airway Smooth Muscle
Am. J. Respir. Crit. Care Med., November 15, 2001; 164(10): S63 - 66.
[Abstract] [Full Text] [PDF]


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