Am. J. Respir. Crit. Care Med., Volume 164, Number 3, August 2001, 358-364

Lower Respiratory Illnesses Promote FEV₁ Decline in Current Smokers But Not Ex-Smokers with Mild Chronic Obstructive Pulmonary Disease
Results from the Lung Health Study

RICHARD E. KANNER, NICHOLAS R. ANTHONISEN, and JOHN E. CONNETT, for the Lung Health Study Research Group

University of Utah Health Sciences Center, Salt Lake City, Utah; and LHS Coordinating Center, Minneapolis, Minnesota

We analyzed Lung Health Study (LHS) data to assess the effect of self-reported lower respiratory illnesses resulting in physician visits (LRI) on lung function. Participants were 5,887 smokers aged 35-60 yr, FEV₁/FVC < 0.70 and FEV₁ of 55-90% predicted. Two-thirds were randomized into an intensive smoking cessation program (SI); one-third were advised only to stop smoking (UC). For 5 yr participants had annual spirometry and questioning regarding LRI. SI had greater rates of smoking cessation than usual care (UC) with fewer LRI (p = 0.0008). Sustained quitters had fewer LRI than continuing smokers (p = 0.0003). In the year LRI occurred, FEV₁ did not change in sustained quitters, but decreased significantly in smokers (p = 0.0001) with some recovery the following year if no LRI occurred. Over 5 yr, LRI had a significant effect on rate of decline of FEV₁ only in smokers. In smokers averaging one LRI/yr over 5 yr there were additional declines in FEV₁ of 7 ml /yr (p = 0.001). Smokers with more than one LRI/yr had greater declines. Chronic bronchitis was associated with increased frequencies of LRI, but did not affect their influence on lung function. Smoking and LRI had an interactive effect on FEV₁ in people with mild COPD, and in smokers frequent LRI may influence the long-term course of the disease.

Keywords: smoking; chronic obstructive pulmonary disease; lower respiratory infections; chronic bronchitis

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