help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by KIMURA, H.
Right arrow Articles by KURIYAMA, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by KIMURA, H.
Right arrow Articles by KURIYAMA, T.

Am. J. Respir. Crit. Care Med., Volume 164, Number 2, July 2001, 319-324

Plasma Monocyte Chemoattractant Protein-1 and Pulmonary Vascular Resistance in Chronic Thromboembolic Pulmonary Hypertension

HIROSHI KIMURA, OSAMU OKADA, NOBUHIRO TANABE, YOSHIHIRO TANAKA, MASARU TERAI, YUICHI TAKIGUCHI, MASAHISA MASUDA, NOBUYUKI NAKAJIMA, KENZO HIROSHIMA, HIDEKUNI INADERA, KOUJI MATSUSHIMA, and TAKAYUKI KURIYAMA

Department of Chest Medicine, Department of Pediatrics, First Department of Surgery, and Department of Pathology, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, Chiba, Japan; Department of Internal Medicine II, Nara Medical University, Nara, Japan; Department of Cardiothoracic Surgery, Japan Self-Defense Force Central Hospital, Tokyo, Japan; and Department of Molecular Preventive Medicine and CREST, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

The pathogenesis of severe pulmonary hypertension seems to be related to inflammatory response in diseased sites. Monocyte chemoattractant protein-1 (MCP-1) has been reported to play a role in the development of congestive heart failure. In this immunological response, activation and migration of leukocytes including macrophages to the inflammatory region are important factors. We hypothesized that the severity of pulmonary hypertension may be related to MCP-1, which is thought to be upregulated by blood pressure or shear stress in pulmonary vasculature as well as by immunological and inflammatory reactions in chronic thromboembolic pulmonary hypertension (CTEPH). Circulating levels of MCP-1, interleukin-1beta (IL-1beta ), and tumor necrosis factor-alpha (TNF-alpha ) were measured by sandwich ELISA in 14 patients with CTEPH. The plasma level of MCP-1 was significantly correlated with pulmonary vascular resistance. In IL-1beta and TNF-alpha , on the other hand, there was no correlation between cytokines and pulmonary hemodynamics. Pathological specimens obtained from the patients with CTEPH undergoing thromboendarterectomy demonstrated immunoreactivity of MCP-1 in endothelium, smooth muscle cells, and macrophages within neointima in the hypertensive large elastic pulmonary artery. We conclude that MCP-1 is upregulated in the remodeling of pulmonary arteries in close association with increased pulmonary vascular resistance in CTEPH.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
W. Yao, A. L. Firth, R. S. Sacks, A. Ogawa, W. R. Auger, P. F. Fedullo, M. M. Madani, G. Y. Lin, N. Sakakibara, P. A. Thistlethwaite, et al.
Identification of putative endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with chronic thromboembolic pulmonary hypertension
Am J Physiol Lung Cell Mol Physiol, June 1, 2009; 296(6): L870 - L878.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
R. Quarck, T. Nawrot, B. Meyns, and M. Delcroix
C-reactive protein a new predictor of adverse outcome in pulmonary arterial hypertension.
J. Am. Coll. Cardiol., April 7, 2009; 53(14): 1211 - 1218.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. Bakouboula, O. Morel, A. Faure, F. Zobairi, L. Jesel, A. Trinh, M. Zupan, M. Canuet, L. Grunebaum, A. Brunette, et al.
Procoagulant Membrane Microparticles Correlate with the Severity of Pulmonary Arterial Hypertension
Am. J. Respir. Crit. Care Med., March 1, 2008; 177(5): 536 - 543.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
O. Sanchez, E. Marcos, F. Perros, E. Fadel, L. Tu, M. Humbert, P. Dartevelle, G. Simonneau, S. Adnot, and S. Eddahibi
Role of Endothelium-derived CC Chemokine Ligand 2 in Idiopathic Pulmonary Arterial Hypertension
Am. J. Respir. Crit. Care Med., November 15, 2007; 176(10): 1041 - 1047.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
N. Galie and N. H. S. Kim
Pulmonary Microvascular Disease in Chronic Thromboembolic Pulmonary Hypertension
Proceedings of the ATS, September 1, 2006; 3(7): 571 - 576.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
P. Joppa, D. Petrasova, B. Stancak, and R. Tkacova
Systemic Inflammation in Patients With COPD and Pulmonary Hypertension.
Chest, August 1, 2006; 130(2): 326 - 333.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. M. Hoeper, E. Mayer, G. Simonneau, and L. J. Rubin
Chronic Thromboembolic Pulmonary Hypertension
Circulation, April 25, 2006; 113(16): 2011 - 2020.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. Herve, E. Fadel, P. Herve, and E. Fadel
Systemic neovascularization of the lung after pulmonary artery occlusion: "decoding the Da Vinci code"
J Appl Physiol, April 1, 2006; 100(4): 1101 - 1102.
[Full Text] [PDF]

Home page
 CirculationHome page
C. Guignabert, B. Raffestin, R. Benferhat, W. Raoul, P. Zadigue, D. Rideau, M. Hamon, S. Adnot, and S. Eddahibi
Serotonin Transporter Inhibition Prevents and Reverses Monocrotaline-Induced Pulmonary Hypertension in Rats
Circulation, May 31, 2005; 111(21): 2812 - 2819.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
N. Tanabe, A. Kimura, S. Amano, O. Okada, Y. Kasahara, K. Tatsumi, M. Takahashi, H. Shibata, M. Yasunami, and T. Kuriyama
Association of clinical features with HLA in chronic pulmonary thromboembolism
Eur. Respir. J., January 1, 2005; 25(1): 131 - 138.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. K. Damas, K. Otterdal, A. Yndestad, H. Aass, N. O. Solum, S. S. Froland, S. Simonsen, P. Aukrust, and A. K. Andreassen
Soluble CD40 Ligand in Pulmonary Arterial Hypertension: Possible Pathogenic Role of the Interaction Between Platelets and Endothelial Cells
Circulation, August 24, 2004; 110(8): 999 - 1005.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
U. Maus, S. Henning, H. Wenschuh, K. Mayer, W. Seeger, and J. Lohmeyer
Role of endothelial MCP-1 in monocyte adhesion to inflamed human endothelium under physiological flow
Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2584 - H2591.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. A. Bradbury, R. Newton, Y.-M. Zhu, J. Stocks, L. Corbett, E. D. Holland, L. H. Pang, and A. J. Knox
Effect of bradykinin, TGF-beta 1, IL-1beta , and hypoxia on COX-2 expression in pulmonary artery smooth muscle cells
Am J Physiol Lung Cell Mol Physiol, October 1, 2002; 283(4): L717 - L725.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Chronic Obstructive Pulmonary Disease, Pollution, Pulmonary Vascular Disease, Transplantation, Pleural Disease, and Lung Cancer in AJRCCM 2001
Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 642 - 662.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2001 American Thoracic Society 		  Red In Translatin