help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by OSHIKAWA, K.
Right arrow Articles by SUGIYAMA, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by OSHIKAWA, K.
Right arrow Articles by SUGIYAMA, Y.

Am. J. Respir. Crit. Care Med., Volume 164, Number 2, July 2001, 277-281

Elevated Soluble ST2 Protein Levels in Sera of Patients with Asthma with an Acute Exacerbation

KATSUHISA OSHIKAWA, KENJI KUROIWA, KENJI TAGO, HIROYUKI IWAHANA, KEN YANAGISAWA, SHOJI OHNO, SHIN-ICHI TOMINAGA, and YUKIHIKO SUGIYAMA

Department of Pulmonary Medicine and Department of Biochemistry, Jichi Medical School, Tochigi, Japan; and Department of Applied Biological Science, Faculty of Science and Technology, Science University of Tokyo, Chiba, Japan

Previous studies have reported that ST2 is preferentially expressed on Th2 cells and plays a critical part in controlling airway inflammation in murine models of asthma. However, the clinical role of ST2 in patients with bronchial asthma remains unclear. In our study, we examined 56 patients with atopic asthma in a nonattack phase and 200 nonatopic normal volunteers for healthy control, and analyzed the relationship of their serum ST2 levels to asthma severity, pulmonary function, and laboratory data. Of the 56 patients with atopic asthma, 30 exhibited asthmatic exacerbation, and their serum ST2 levels were also analyzed. The serum ST2 levels were low, but a statistical difference was found between patients with nonattack asthma and the healthy control group (p < 0.05). We also found a differential rise of serum ST2 level that correlates well with the severity of asthma exacerbation. Furthermore, the serum ST2 levels during asthma exacerbation statistically correlated with the percentage of predicted peak expiratory flow (r = -0.634, p = 0.004) and PaCO2 (r = 0.516, p = 0.003). These results suggest that soluble human ST2 protein in sera may be related to Th2-mediated allergic inflammation inducing acute exacerbation in patients with atopic asthma.

Keywords: ST2; bronchial asthma; helper T cell type-2; acute exacerbation




This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
K. M. Kroeger, B. M. Sullivan, and R. M. Locksley
IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38{alpha}-dependent pathway
J. Leukoc. Biol., October 1, 2009; 86(4): 769 - 778.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Q. Espinassous, E. Garcia-de-Paco, I. Garcia-Verdugo, M. Synguelakis, S. von Aulock, J.-M. Sallenave, A. N. J. McKenzie, and J. Kanellopoulos
IL-33 Enhances Lipopolysaccharide-Induced Inflammatory Cytokine Production from Mouse Macrophages by Regulating Lipopolysaccharide Receptor Complex
J. Immunol., July 15, 2009; 183(2): 1446 - 1455.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. N. Pushparaj, H. K. Tay, S. C. H'ng, N. Pitman, D. Xu, A. McKenzie, F. Y. Liew, and A. J. Melendez
The cytokine interleukin-33 mediates anaphylactic shock
PNAS, June 16, 2009; 106(24): 9773 - 9778.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. Pecaric-Petkovic, S. A. Didichenko, S. Kaempfer, N. Spiegl, and C. A. Dahinden
Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33
Blood, February 12, 2009; 113(7): 1526 - 1534.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Suzukawa, M. Iikura, R. Koketsu, H. Nagase, C. Tamura, A. Komiya, S. Nakae, K. Matsushima, K. Ohta, K. Yamamoto, et al.
An IL-1 Cytokine Member, IL-33, Induces Human Basophil Activation via Its ST2 Receptor
J. Immunol., November 1, 2008; 181(9): 5981 - 5989.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
S. U. Rehman, T. Mueller, and J. L. Januzzi Jr
Characteristics of the Novel Interleukin Family Biomarker ST2 in Patients With Acute Heart Failure
J. Am. Coll. Cardiol., October 28, 2008; 52(18): 1458 - 1465.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
J. Diez
Serum Soluble ST2 as a Biochemical Marker of Acute Heart Failure: Future Areas of Research
J. Am. Coll. Cardiol., October 28, 2008; 52(18): 1466 - 1467.
[Full Text] [PDF]

Home page
 Int ImmunolHome page
M. D. Smithgall, M. R. Comeau, B.-R. Park Yoon, D. Kaufman, R. Armitage, and D. E. Smith
IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK Cells
Int. Immunol., August 1, 2008; 20(8): 1019 - 1030.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
L. H. Ho, T. Ohno, K. Oboki, N. Kajiwara, H. Suto, M. Iikura, Y. Okayama, S. Akira, H. Saito, S. J. Galli, et al.
IL-33 induces IL-13 production by mouse mast cells independently of IgE-Fc{epsilon}RI signals
J. Leukoc. Biol., December 1, 2007; 82(6): 1481 - 1490.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
X. Huang, W. Du, R. P. Barrett, and L. D. Hazlett
ST2 Is Essential for Th2 Responsiveness and Resistance to Pseudomonas aeruginosa Keratitis
Invest. Ophthalmol. Vis. Sci., October 1, 2007; 48(10): 4626 - 4633.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Hayakawa, M. Hayakawa, A. Kume, and S.-i. Tominaga
Soluble ST2 Blocks Interleukin-33 Signaling in Allergic Airway Inflammation
J. Biol. Chem., September 7, 2007; 282(36): 26369 - 26380.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. A. Chackerian, E. R. Oldham, E. E. Murphy, J. Schmitz, S. Pflanz, and R. A. Kastelein
IL-1 Receptor Accessory Protein and ST2 Comprise the IL-33 Receptor Complex
J. Immunol., August 15, 2007; 179(4): 2551 - 2555.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
J. L. Januzzi Jr, W. F. Peacock, A. S. Maisel, C. U. Chae, R. L. Jesse, A. L. Baggish, M. O'Donoghue, R. Sakhuja, A. A. Chen, R. R.J. van Kimmenade, et al.
Measurement of the Interleukin Family Member ST2 in Patients With Acute Dyspnea: Results From the PRIDE (Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department) Study
J. Am. Coll. Cardiol., August 14, 2007; 50(7): 607 - 613.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
J. S. Siegle, N. Hansbro, C. Herbert, M. Yang, P. S. Foster, and R. K. Kumar
Airway Hyperreactivity in Exacerbation of Chronic Asthma Is Independent of Eosinophilic Inflammation
Am. J. Respir. Cell Mol. Biol., November 1, 2006; 35(5): 565 - 570.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
M. Shimizu, A. Matsuda, K. Yanagisawa, T. Hirota, M. Akahoshi, N. Inomata, K. Ebe, K. Tanaka, H. Sugiura, K. Nakashima, et al.
Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis
Hum. Mol. Genet., October 1, 2005; 14(19): 2919 - 2927.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
R. Whelan, C. Kim, M. Chen, J. Leiter, M.M. Grunstein, and H. Hakonarson
Role and regulation of interleukin-1 molecules in pro-asthmatic sensitised airway smooth muscle
Eur. Respir. J., October 1, 2004; 24(4): 559 - 567.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. Shimpo, D. A. Morrow, E. O. Weinberg, M. S. Sabatine, S. A. Murphy, E. M. Antman, and R. T. Lee
Serum Levels of the Interleukin-1 Receptor Family Member ST2 Predict Mortality and Clinical Outcome in Acute Myocardial Infarction
Circulation, May 11, 2004; 109(18): 2186 - 2190.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. W. Kamp
Idiopathic Pulmonary Fibrosis: The Inflammation Hypothesis Revisited
Chest, October 1, 2003; 124(4): 1187 - 1190.
[Full Text] [PDF]

Home page
 ChestHome page
S. Tajima, K. Oshikawa, S.-i. Tominaga, and Y. Sugiyama
The Increase in Serum Soluble ST2 Protein Upon Acute Exacerbation of Idiopathic Pulmonary Fibrosis
Chest, October 1, 2003; 124(4): 1206 - 1214.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
K. Honda, M. Arima, G. Cheng, S. Taki, H. Hirata, F. Eda, F. Fukushima, B. Yamaguchi, M. Hatano, T. Tokuhisa, et al.
Prostaglandin D2 Reinforces Th2 Type Inflammatory Responses of Airways to Low-dose Antigen through Bronchial Expression of Macrophage-derived Chemokine
J. Exp. Med., August 18, 2003; 198(4): 533 - 543.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
E. O. Weinberg, M. Shimpo, S. Hurwitz, S.-i. Tominaga, J.-L. Rouleau, and R. T. Lee
Identification of Serum Soluble ST2 Receptor as a Novel Heart Failure Biomarker
Circulation, February 11, 2003; 107(5): 721 - 726.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
P. Kropf, S. Herath, R. Tewari, N. Syed, R. Klemenz, and I. Muller
Identification of Two Distinct Subpopulations of Leishmania major-Specific T Helper 2 Cells
Infect. Immun., October 1, 2002; 70(10): 5512 - 5520.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. Oshikawa, K. Yanagisawa, S. Ohno, S.-I. Tominaga, and Y. Sugiyama
Expression of ST2 in Helper T Lymphocytes of Malignant Pleural Effusions
Am. J. Respir. Crit. Care Med., April 1, 2002; 165(7): 1005 - 1009.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Asthma, Airway Biology, and Nasal Disorders in AJRCCM 2001
Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 598 - 618.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2001 American Thoracic Society 		  Red In Translatin