help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow A correction has been published
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by LIM, S.
Right arrow Articles by BARNES, P. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by LIM, S.
Right arrow Articles by BARNES, P. J.

Am. J. Respir. Crit. Care Med., Volume 164, Number 2, July 2001, 273-276

Low-dose Theophylline Reduces Eosinophilic Inflammation but Not Exhaled Nitric Oxide in Mild Asthma

SAM LIM, KATSUYUKI TOMITA, GAETANO CARRAMORI, ANON JATAKANON, BRIAN OLIVER, ANDREAS KELLER, IAN ADCOCK, KIAN FAN CHUNG, and PETER J. BARNES

Department of Thoracic Medicine, Imperial College School of Medicine, National Heart and Lung Institute, London, United Kingdom; and Byk Gulden Pharmaceuticals, Konstanz, Germany

Theophylline is well-established in the management of asthma, and there is some evidence of an antiinflammatory effect in asthma. It is not known whether theophylline affects inflammatory markers such as sputum eosinophils and exhaled nitric oxide (NO) in patients with mild asthma not receiving inhaled steroid therapy. In a double-blind, placebo-controlled, cross-over study of 15 patients with mild asthma, we assessed the effect of low-dose theophylline therapy (250 mg twice per day) on eosinophils in induced sputum, bronchoalveolar lavage (BAL) and airway biopsies at the end of both the treatment and placebo periods. Measurements of exhaled nitric oxide (NO) were made at the end of the active and placebo treatment periods of 5 wk each. Low-dose theophylline (mean serum level, 6.1 mg/L) led to a significant reduction in mean (95% confidence interval [CI]) sputum eosinophils from 11.3% (7.80-14.76%) to 8.0% (5.46-10.44%), BAL eosinophils from 3.4% (2.4-4.4%) to 1.7% (1.1-2.3%) and biopsy eosinophils from 1.83% (0.76-2.89%) to 1.20% (0.27-2.13%) compared with placebo (all p < 0.05). There was no significant change in levels of exhaled NO or improvement in lung function and bronchial responsiveness. Low-dose theophylline induced antiinflammatory effects in asthma, reflected by a fall in airway eosinophils with no change in exhaled NO or changes in lung function.




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Stick and P. Franklin
NO More Dogma
Am. J. Respir. Crit. Care Med., January 15, 2009; 179(2): 87 - 88.
[Full Text] [PDF]

Home page
 ChestHome page
K. G. Lim and C. Mottram
The Use of Fraction of Exhaled Nitric Oxide in Pulmonary Practice
Chest, May 1, 2008; 133(5): 1232 - 1242.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
The American Lung Association Asthma Clinical Rese
Clinical Trial of Low-Dose Theophylline and Montelukast in Patients with Poorly Controlled Asthma
Am. J. Respir. Crit. Care Med., February 1, 2007; 175(3): 235 - 242.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
P. J. Barnes
Theophylline in Chronic Obstructive Pulmonary Disease: New Horizons
Proceedings of the ATS, November 1, 2005; 2(4): 334 - 339.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. F. Chung
Erratum: Low-Dose Theophylline Reduces Eosinophilic Inflammation But Not Exhaled Nitric Oxide in Mild Asthma
Am. J. Respir. Crit. Care Med., August 1, 2004; 170(3): 345 - 345.
[Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
U. Frey, C. Kuehni, H. Roiha, M. Cernelc, B. Reinmann, J. H. Wildhaber, and G. L. Hall
Maternal Atopic Disease Modifies Effects of Prenatal Risk Factors on Exhaled Nitric Oxide in Infants
Am. J. Respir. Crit. Care Med., August 1, 2004; 170(3): 260 - 265.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. G. Cosio, B. Mann, K. Ito, E. Jazrawi, P. J. Barnes, K. F. Chung, and I. M. Adcock
Histone Acetylase and Deacetylase Activity in Alveolar Macrophages and Blood Mononocytes in Asthma
Am. J. Respir. Crit. Care Med., July 15, 2004; 170(2): 141 - 147.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. J. Barnes
Theophylline: New Perspectives for an Old Drug
Am. J. Respir. Crit. Care Med., March 15, 2003; 167(6): 813 - 818.
[Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Ito, S. Lim, G. Caramori, B. Cosio, K. F. Chung, I. M. Adcock, and P. J. Barnes
A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression
PNAS, June 25, 2002; 99(13): 8921 - 8926.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. J. Lipworth, F. Chung, P. Barnes, and S. Lim
EFFECTS OF THEOPHYLLINE ON AIRWAY EOSINOPHILS
Am. J. Respir. Crit. Care Med., March 15, 2002; 165(6): 845 - 845.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Asthma, Airway Biology, and Nasal Disorders in AJRCCM 2001
Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 598 - 618.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. M. Stick
Exhaled Nitric Oxide in Difficult Childhood Asthma . More Light or Still Chasing Shadows?
Am. J. Respir. Crit. Care Med., October 15, 2001; 164(8): 1335 - 1336.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2001 American Thoracic Society 		  SOTA, FL