help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by JOHN KIMOFF, R.
Right arrow Articles by GENDRON, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by JOHN KIMOFF, R.
Right arrow Articles by GENDRON, D.

Am. J. Respir. Crit. Care Med., Volume 164, Number 2, July 2001, 250-255

Upper Airway Sensation in Snoring and Obstructive Sleep Apnea

R. JOHN KIMOFF, EMILIA SFORZA, VICTORIA CHAMPAGNE, LINDA OFIARA, and DANIEL GENDRON

Respiratory Division, Royal Victoria Hospital Site and Department of Neurology, McGill University Health Centre, Montreal, Quebec, Canada

Previous studies indicate that upper airway (UA) sensory receptors play a role in the maintenance of UA patency and contribute to arousal in response to airway occlusion. An impairment of UA sensory function could therefore predispose to UA obstruction during sleep. We hypothesized that UA sensation is impaired in obstructive sleep apnea (OSA), and that sensation improves after treatment with nasal continuous positive airway pressure (CPAP). We measured two-point discrimination (2PD) and vibratory sensation thresholds (VT) in 37 patients with OSA (mean [± SE] apnea- hypopnea index [AHI] = 39 ± 5 events/h), 12 nonapneic snorers (SN), and 15 control subjects (CL). Sensory thresholds were determined in the UA and on the lip and hand as control sites. Both 2PD and VT were similar among the three groups at the lip and hand sites but were significantly reduced in the UA of OSA and SN subjects versus CL (p < 0.05). Values for 2PD and VT in the UA of OSA versus SN were not significantly different. Sensory measures were repeated after 6 mo in 23 OSA patients treated with CPAP as well as in 18 untreated patients. Thresholds for 2PD and VT at control sites remained identical in both groups, as did 2PD for the UA. However, VT in the UA showed a significant improvement in treated (4.4 ± 0.2 pre-CPAP versus 3.8 ± 0.2 mm post-CPAP, p < 0.05) but not untreated patients. These findings indicate the presence of a selective impairment in the detection of mechanical stimuli in the UA of patients with OSA and SN, which is partially reversible after treatment with nasal CPAP in patients with OSA.




This article has been cited by other articles:


Home page
 ChestHome page
L. Hagander, R. Harlid, and E. Svanborg
Quantitative Sensory Testing in the Oropharynx: A Means of Showing Nervous Lesions in Patients With Obstructive Sleep Apnea and Snoring
Chest, August 1, 2009; 136(2): 481 - 489.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
H. Schneider, V. Krishnan, L. E. Pichard, S. P. Patil, P. L. Smith, and A. R. Schwartz
Inspiratory duty cycle responses to flow limitation predict nocturnal hypoventilation
Eur. Respir. J., May 1, 2009; 33(5): 1068 - 1076.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. J. Eckert, A. Malhotra, Y. L. Lo, D. P. White, and A. S. Jordan
The Influence of Obstructive Sleep Apnea and Gender on Genioglossus Activity During Rapid Eye Movement Sleep
Chest, April 1, 2009; 135(4): 957 - 964.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. L. Verhulst, L. Aerts, S. Jacobs, N. Schrauwen, D. Haentjens, R. Claes, H. Vaerenberg, L. F. Van Gaal, W. A. De Backer, and K. N. Desager
Sleep-Disordered Breathing, Obesity, and Airway Inflammation in Children and Adolescents
Chest, December 1, 2008; 134(6): 1169 - 1175.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. D. Ray, T. Ogasa, U. J. Magalang, J. A. Krasney, and G. A. Farkas
Aging increases upper airway collapsibility in Fischer 344 rats
J Appl Physiol, November 1, 2008; 105(5): 1471 - 1476.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Younes
Role of respiratory control mechanisms in the pathogenesis of obstructive sleep disorders
J Appl Physiol, November 1, 2008; 105(5): 1389 - 1405.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. R. Schwartz, S. P. Patil, H. Schneider, and P. L. Smith
Modelling pathogenic mechanisms of upper airway dysfunction in the molecular age
Eur. Respir. J., August 1, 2008; 32(2): 255 - 258.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
I. Almendros, A. Carreras, J. Ramirez, J. M. Montserrat, D. Navajas, and R. Farre
Upper airway collapse and reopening induce inflammation in a sleep apnoea model
Eur. Respir. J., August 1, 2008; 32(2): 399 - 404.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
D. J. Eckert and A. Malhotra
Pathophysiology of Adult Obstructive Sleep Apnea
Proceedings of the ATS, February 15, 2008; 5(2): 144 - 153.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
J. M. Beecroft, V. Hoffstein, A. Pierratos, C. T. Chan, P. McFarlane, and P. J. Hanly
Nocturnal haemodialysis increases pharyngeal size in patients with sleep apnoea and end-stage renal disease
Nephrol. Dial. Transplant., February 1, 2008; 23(2): 673 - 679.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. M. Beecroft, V. Hoffstein, A. Pierratos, C. T. Chan, P. A. McFarlane, and P. J. Hanly
Pharyngeal narrowing in end-stage renal disease: implications for obstructive sleep apnoea
Eur. Respir. J., November 1, 2007; 30(5): 965 - 971.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
A. S Jordan, A. Wellman, R. C Heinzer, Y.-L. Lo, K. Schory, L. Dover, S. Gautam, A. Malhotra, and D. P White
Mechanisms used to restore ventilation after partial upper airway collapse during sleep in humans
Thorax, October 1, 2007; 62(10): 861 - 867.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. P. Patil, H. Schneider, A. R. Schwartz, and P. L. Smith
Adult Obstructive Sleep Apnea: Pathophysiology and Diagnosis
Chest, July 1, 2007; 132(1): 325 - 337.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
V. Jobin, V. Champagne, J. Beauregard, I. Charbonneau, D. H. McFarland, and R. J. Kimoff
Swallowing function and upper airway sensation in obstructive sleep apnea
J Appl Physiol, April 1, 2007; 102(4): 1587 - 1594.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. P. Patil, H. Schneider, J. J. Marx, E. Gladmon, A. R. Schwartz, and P. L. Smith
Neuromechanical control of upper airway patency during sleep
J Appl Physiol, February 1, 2007; 102(2): 547 - 556.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. L. Horner
Contributions of passive mechanical loads and active neuromuscular compensation to upper airway collapsibility during sleep
J Appl Physiol, February 1, 2007; 102(2): 510 - 512.
[Full Text] [PDF]

Home page
 ChestHome page
A. D. Goldbart, J. Krishna, R. C. Li, L. D. Serpero, and D. Gozal
Inflammatory Mediators in Exhaled Breath Condensate of Children With Obstructive Sleep Apnea Syndrome.
Chest, July 1, 2006; 130(1): 143 - 148.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. J. Schwab, M. Pasirstein, L. Kaplan, R. Pierson, A. Mackley, R. Hachadoorian, R. Arens, G. Maislin, and A. I. Pack
Family Aggregation of Upper Airway Soft Tissue Structures in Normal Subjects and Patients with Sleep Apnea
Am. J. Respir. Crit. Care Med., February 15, 2006; 173(4): 453 - 463.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
D. P. White
The Pathogenesis of Obstructive Sleep Apnea: Advances in the Past 100 Years
Am. J. Respir. Cell Mol. Biol., January 1, 2006; 34(1): 1 - 6.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. M. Ryan and T. D. Bradley
Pathogenesis of obstructive sleep apnea
J Appl Physiol, December 1, 2005; 99(6): 2440 - 2450.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. P. White
Pathogenesis of Obstructive and Central Sleep Apnea
Am. J. Respir. Crit. Care Med., December 1, 2005; 172(11): 1363 - 1370.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. S. Doherty, P. Nolan, and W. T. McNicholas
Effects of topical anesthesia on upper airway resistance during wake-sleep transitions
J Appl Physiol, August 1, 2005; 99(2): 549 - 555.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
M Dematteis, P Levy, and J-L Pepin
A simple procedure for measuring pharyngeal sensitivity: a contribution to the diagnosis of sleep apnoea
Thorax, May 1, 2005; 60(5): 418 - 426.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. M. O'Driscoll, K. Kostikas, A. K. Simonds, and M. J. Morrell
Occlusion of the upper airway does not augment the cardiovascular response to arousal from sleep in humans
J Appl Physiol, April 1, 2005; 98(4): 1349 - 1355.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. H. Boyd, B. J. Petrof, Q. Hamid, R. Fraser, and R. J. Kimoff
Upper Airway Muscle Inflammation and Denervation Changes in Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med., September 1, 2004; 170(5): 541 - 546.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
R B Fogel, A Malhotra, and D P White
Sleep {middle dot} 2: Pathophysiology of obstructive sleep apnoea/hypopnoea syndrome
Thorax, February 1, 2004; 59(2): 159 - 163.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. R. Schwartz, H. Schneider, and P. L. Smith
Upper airway surface tension: is it a significant cause of airflow obstruction during sleep?
J Appl Physiol, November 1, 2003; 95(5): 1759 - 1760.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. J. Schwab, M. Pasirstein, R. Pierson, A. Mackley, R. Hachadoorian, R. Arens, G. Maislin, and A. I. Pack
Identification of Upper Airway Anatomic Risk Factors for Obstructive Sleep Apnea with Volumetric Magnetic Resonance Imaging
Am. J. Respir. Crit. Care Med., September 1, 2003; 168(5): 522 - 530.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. B. Berry, D. P. White, J. Roper, G. Pillar, R. B. Fogel, M. Stanchina, and A. Malhotra
Awake negative pressure reflex response of the genioglossus in OSA patients and normal subjects
J Appl Physiol, May 1, 2003; 94(5): 1875 - 1882.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. A. Henderson, M. A. Woo, P. M. Macey, K. E. Macey, R. C. Frysinger, J. R. Alger, F. Yan-Go, and R. M. Harper
Neural responses during Valsalva maneuvers in obstructive sleep apnea syndrome
J Appl Physiol, March 1, 2003; 94(3): 1063 - 1074.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Akay, J. C. Leiter, and J. A. Daubenspeck
Reduced respiratory-related evoked activity in subjects with obstructive sleep apnea syndrome
J Appl Physiol, February 1, 2003; 94(2): 429 - 438.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. Guilleminault and R. Dave
Upper Airway Resistance Syndrome, Insomnia, and Functional Somatic Syndromes
Chest, January 1, 2003; 123(1): 12 - 14.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. J. J. Back, P. O. Tervahartiala, A. K. Piilonen, M. M. Partinen, and J. S. Ylikoski
Bipolar Radiofrequency Thermal Ablation of the Soft Palate in Habitual Snorers without Significant Desaturations Assessed by Magnetic Resonance Imaging
Am. J. Respir. Crit. Care Med., September 15, 2002; 166(6): 865 - 871.
[Abstract] [Full Text]

Home page
 ChestHome page
C. Guilleminault, K. Li, N.-H. Chen, and D. Poyares
Two-Point Palatal Discrimination in Patients With Upper Airway Resistance Syndrome, Obstructive Sleep Apnea Syndrome, and Normal Control Subjects*
Chest, September 1, 2002; 122(3): 866 - 870.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. Rubinstein, R. J. Kimoff, V. Champagne, and E. Svanborg
UPPER AIRWAY INFLAMMATION IN OBSTRUCTIVE SLEEP APNEA
Am. J. Respir. Crit. Care Med., April 1, 2002; 165(7): 1023 - 1024.
[Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Sleep-Disordered Breathing, Control of Breathing, Respiratory Muscles, and Pulmonary Function Testing in AJRCCM 2001
Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 584 - 597.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. Svanborg
Upper Airway Nerve Lesions in Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med., July 15, 2001; 164(2): 187 - 189.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2001 American Thoracic Society 		  ATS 2008 State of the Art Course