help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Online Data Supplement
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by LUM, S.
Right arrow Articles by STOCKS, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by LUM, S.
Right arrow Articles by STOCKS, J.

Am. J. Respir. Crit. Care Med., Volume 164, Number 11, December 2001, 2078-2084

The Association between Birthweight, Sex, and Airway Function in Infants of Nonsmoking Mothers

SOOKY LUM, AH-FONG HOO, CAROL DEZATEUX, IRIS GOETZ, ANGIE WADE, LAURA DEROOY, KATE COSTELOE, and JANET STOCKS

Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit and Center for Paediatric Epidemiology and Biostatistics, Institute of Child Health and Great Ormond Street Hospital NHS Trust; Neonatal Unit, University College Hospital, and Department of Child Health, Barts and the Royal London School of Medicine and Dentistry, Homerton Hospital, London, United Kingdom

The risk of respiratory illness and death is increased in infants of low birthweight for gestational age, but the underlying physiologic mechanisms remain unclear. We examined the hypothesis that airway function is diminished in infants of low birthweight for gestational age, independent of exposure to maternal smoking. Respiratory function was measured using partial and raised volume forced expiratory maneuvers in 103 infants (> 35 wk gestation; 56 boys) not exposed pre- or postnatally to maternal smoking who, according to birthweight, were either small (SGA; n = 38) or appropriate (AGA; n = 65) for gestational age. At testing, SGA infants were of similar postnatal age (mean [SD]: SGA 6.8 [2.4] wk, AGA 5.9 [2.3] wk), but remained shorter and lighter than AGA infants. In univariate analyses, FVC, forced expired volume in 0.4 s (FEV0.4), and FEF75 were significantly diminished in SGA compared with AGA infants (mean [95% CI of difference]: FVC: 127 versus 143 ml [-29, -2]; FEV0.4: 112 versus 125 ml [-24, -2]; and FEF75: 173 versus 203 ml s-1 [-57, -3], respectively), but these differences were no longer significant after allowing for sex and body size. Furthermore, FEF75 was on average 35 ml s-1 lower in boys than girls (95% CI: -61, -8). We conclude that diminished airway function in SGA infants shortly after birth appears to be primarily mediated through impaired somatic growth.




This article has been cited by other articles:


Home page
 J. Lipid Res.Home page
P. E. Cogo, C. Ori, M. Simonato, G. Verlato, I. Isak, A. Hamvas, and V. P. Carnielli
Metabolic precursors of surfactant disaturated-phosphatidylcholine in preterms with respiratory distress
J. Lipid Res., November 1, 2009; 50(11): 2324 - 2331.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
G Hulskamp, S Lum, J Stocks, A Wade, A F Hoo, K Costeloe, J Hawdon, K Deeptha, and J J Pillow
Association of prematurity, lung disease and body size with lung volume and ventilation inhomogeneity in unsedated neonates: a multicentre study
Thorax, March 1, 2009; 64(3): 240 - 245.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
W. J. Kozlowska, A. Bush, A. Wade, P. Aurora, S. B. Carr, R. A. Castle, A.-F. Hoo, S. Lum, J. Price, S. Ranganathan, et al.
Lung Function from Infancy to the Preschool Years after Clinical Diagnosis of Cystic Fibrosis
Am. J. Respir. Crit. Care Med., July 1, 2008; 178(1): 42 - 49.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. Friedrich, P. M. C. Pitrez, R. T. Stein, M. Goldani, R. Tepper, and M. H. Jones
Growth Rate of Lung Function in Healthy Preterm Infants
Am. J. Respir. Crit. Care Med., December 15, 2007; 176(12): 1269 - 1273.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
S. Lum, P. Gustafsson, H. Ljungberg, G. Hulskamp, A. Bush, S. B Carr, R. Castle, A.-f. Hoo, J. Price, S. Ranganathan, et al.
Early detection of cystic fibrosis lung disease: multiple-breath washout versus raised volume tests
Thorax, April 1, 2007; 62(4): 341 - 347.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. Rusconi, C. Galassi, F. Forastiere, M. Bellasio, M. De Sario, G. Ciccone, L. Brunetti, E. Chellini, G. Corbo, S. La Grutta, et al.
Maternal Complications and Procedures in Pregnancy and at Birth and Wheezing Phenotypes in Children
Am. J. Respir. Crit. Care Med., January 1, 2007; 175(1): 16 - 21.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
M R Thomas, L Marston, G F Rafferty, S Calvert, N Marlow, J L Peacock, and A Greenough
Respiratory function of very prematurely born infants at follow up: influence of sex
Arch. Dis. Child. Fetal Neonatal Ed., May 1, 2006; 91(3): F197 - F201.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. Friedrich, R. T. Stein, P. M. C. Pitrez, A. L. Corso, and M. H. Jones
Reduced Lung Function in Healthy Preterm Infants in the First Months of Life
Am. J. Respir. Crit. Care Med., February 15, 2006; 173(4): 442 - 447.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
ATS/ERS Statement: Raised Volume Forced Expirations in Infants: Guidelines for Current Practice
Am. J. Respir. Crit. Care Med., December 1, 2005; 172(11): 1463 - 1471.
[Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
A Greenough, E Limb, L Marston, N Marlow, S Calvert, and J Peacock
Risk factors for respiratory morbidity in infancy after very premature birth
Arch. Dis. Child. Fetal Neonatal Ed., July 1, 2005; 90(4): F320 - f323.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. Greenough, B. Yuksel, and P. Cheeseman
Effect of in utero growth retardation on lung function at follow-up of prematurely born infants
Eur. Respir. J., November 1, 2004; 24(5): 731 - 733.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
R. L. Miller, R. Garfinkel, M. Horton, D. Camann, F. P. Perera, R. M. Whyatt, and P. L. Kinney
Polycyclic Aromatic Hydrocarbons, Environmental Tobacco Smoke, and Respiratory Symptoms in an Inner-city Birth Cohort
Chest, October 1, 2004; 126(4): 1071 - 1078.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A.-F. Hoo, J. Stocks, S. Lum, A. M. Wade, R. A. Castle, K. L. Costeloe, and C. Dezateux
Development of Lung Function in Early Life: Influence of Birth Weight in Infants of Nonsmokers
Am. J. Respir. Crit. Care Med., September 1, 2004; 170(5): 527 - 533.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. S. Lucas, H. M. Inskip, K. M. Godfrey, C. T. Foreman, J. O. Warner, R. K. Gregson, and J. B. Clough
Small Size at Birth and Greater Postnatal Weight Gain: Relationships to Diminished Infant Lung Function
Am. J. Respir. Crit. Care Med., September 1, 2004; 170(5): 534 - 540.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J.J. Pillow, H. Ljungberg, G. Hulskamp, and J. Stocks
Functional residual capacity measurements in healthy infants: ultrasonic flow meter versus a mass spectrometer
Eur. Respir. J., May 1, 2004; 23(5): 763 - 768.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. C. Ranganathan, J. Stocks, C. Dezateux, A. Bush, A. Wade, S. Carr, R. Castle, R. Dinwiddie, A.-F. Hoo, S. Lum, et al.
The Evolution of Airway Function in Early Childhood Following Clinical Diagnosis of Cystic Fibrosis
Am. J. Respir. Crit. Care Med., April 15, 2004; 169(8): 928 - 933.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
C Dezateux, S Lum, A-F Hoo, J Hawdon, K Costeloe, and J Stocks
Low birth weight for gestation and airway function in infancy: exploring the fetal origins hypothesis
Thorax, January 1, 2004; 59(1): 60 - 66.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S.C. Ranganathan, I. Goetz, A-F. Hoo, S. Lum, R. Castle, J. Stocks, and and the London Collaborative Cystic Fibrosis Group
Assessment of tidal breathing parameters in infants with cystic fibrosis
Eur. Respir. J., November 1, 2003; 22(5): 761 - 766.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. Hulskamp, A.-f. Hoo, H. Ljungberg, S. Lum, J. J. Pillow, and J. Stocks
Progressive Decline in Plethysmographic Lung Volumes in Infants: Physiology or Technology?
Am. J. Respir. Crit. Care Med., October 15, 2003; 168(8): 1003 - 1009.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. G. Elliot, N. G. Carroll, A. L. James, and P. J. Robinson
Airway Alveolar Attachment Points and Exposure to Cigarette Smoke In Utero
Am. J. Respir. Crit. Care Med., January 1, 2003; 167(1): 45 - 49.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Compliance (COMmunicate PLease wIth Less Abbreviations, Noun Clusters, and Exclusiveness)
Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): 1534 - 1536.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. C. Ranganathan, A. Bush, C. Dezateux, S. B. Carr, A.-F. Hoo, S. Lum, S. Madge, J. Price, J. Stroobant, A. Wade, et al.
Relative Ability of Full and Partial Forced Expiratory Maneuvers to Identify Diminished Airway Function in Infants with Cystic Fibrosis
Am. J. Respir. Crit. Care Med., November 15, 2002; 166(10): 1350 - 1357.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A.-F. Hoo, C. Dezateux, J. P. Hanrahan, T. J. Cole, R. S. Tepper, and J. Stocks
Sex-Specific Prediction Equations for VmaxFRC in Infancy . A Multicenter Collaborative Study
Am. J. Respir. Crit. Care Med., April 15, 2002; 165(8): 1084 - 1092.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Pediatrics, Surfactant, and Cystic Fibrosis in AJRCCM 2001
Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 619 - 630.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2001 American Thoracic Society 		  SOTA, FL